Zobrazeno 1 - 10
of 85
pro vyhledávání: '"James B. Whitney"'
Autor:
James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is s
Externí odkaz:
https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1
Autor:
Christiaan H. van Dorp, Jessica M. Conway, Dan H. Barouch, James B. Whitney, Alan S. Perelson, Miles P. Davenport
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 10 (2020)
In order to assess the efficacy of novel HIV-1 treatments leading to a functional cure, the time to viral rebound is frequently used as a surrogate endpoint. The longer the time to viral rebound, the more efficacious the therapy. In support of such a
Externí odkaz:
https://doaj.org/article/79b87727fbb144a7986e7ee5b942bb58
Autor:
Nikki P. L. Toledo, Hongzhao Li, Robert W. Omange, Tamara G. Dacoba, Jose Crecente-Campo, Dane Schalk, Mohammad A. Kashem, Eva Rakasz, Nancy Schultz-Darken, Qingsheng Li, James B. Whitney, Maria J. Alonso, Francis A. Plummer, Ma Luo
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Studies have shown that vaccine vectors and route of immunization can differentially activate different arms of the immune system. However, the effects of different HIV vaccine immunogens on mucosal inflammation have not yet been studied. Because muc
Externí odkaz:
https://doaj.org/article/f5036d8582ec48499d95ddd2513a2d67
Autor:
Gabriela M. Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M. Folkvord, Justin M. Greene, Jason S. Reed, Jeffery J. Stanton, Alfred W. Legasse, Theodore Hobbs, Lauren D. Martin, Byung S. Park, James B. Whitney, Emily K. Jeng, Hing C. Wong, Douglas F. Nixon, R. Brad Jones, Elizabeth Connick, Pamela J. Skinner, Jonah B. Sacha
Publikováno v:
Blood Advances, Vol 2, Iss 2, Pp 76-84 (2018)
Abstract: Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human inte
Externí odkaz:
https://doaj.org/article/eefee46bd3354844aa52e77eb0fb72eb
Autor:
James B. Whitney, Mark A. Wainberg
Publikováno v:
McGill Journal of Medicine, Vol 6, Iss 2 (2002)
Tuberculosis is an ancient disease that has held close association with humans for millennia. Through persistence, this remarkably successful organism has managed to infect an estimated third of the world's population. Declining rates of tuberculosis
Externí odkaz:
https://doaj.org/article/fb3316663ceb45ef8261f30bfd65c57c
Autor:
Theron Hamilton, Faith C. Blum, Kenneth G. Frey, Mark G. Lewis, D. Scott Merrell, Joseph J. Mattapallil, Britney L. Hardy, Kimberly A. Bishop-Lilly, James B. Whitney
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Human immunodeficiency virus (HIV) infection is characterized by a massive loss of CD4 T cells in the gastrointestinal tract (GIT) that is accompanied by changes in the gut microbiome and microbial translocation that contribute to inflammation and ch
Autor:
Francis A. Plummer, Andrew B Lambe, Dane Schalk, Xiao-Qing Liu, Michael S. Seaman, Yanmin Wan, Binhua Liang, Ma Luo, Nikki Toledo, Jorge F. Correia-Pinto, Tamara G Dacoba, José Crecente-Campo, María J. Alonso, James B. Whitney, Lewis R. Liu, Yan Hai, Hongzhao Li, Nancy Schultz-Darken, Lin Li, Mohammad Abul Kashem, Robert W Omange, Robert Balshaw, Qingsheng Li, So-Yon Lim
Publikováno v:
J Clin Invest
After over 3 decades of research, an effective anti-HIV vaccine remains elusive. The recently halted HVTN702 clinical trial not only further stresses the challenge to develop an effective HIV vaccine but also emphasizes that unconventional and novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14324fd8b69c8978726682577c9042a1
https://europepmc.org/articles/PMC7685735/
https://europepmc.org/articles/PMC7685735/
Autor:
Eva G. Rakasz, Ma Luo, José Crecente-Campo, María J. Alonso, Hongzhao Li, Tamara G Dacoba, Qingsheng Li, James B. Whitney, Nikki Toledo, Nancy Schultz-Darken, Francis A. Plummer, Robert W Omange, Dane Schalk, Mohammad Abul Kashem
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Studies have shown that vaccine vectors and route of immunization can differentially activate different arms of the immune system. However, the effects of different HIV vaccine immunogens on mucosal inflammation have not yet been studied. Because muc
Autor:
Jessica M. Conway, Christiaan H. van Dorp, Dan H. Barouch, Alan S. Perelson, James B. Whitney
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 10, p e1008241 (2020)
PLoS Computational Biology, Vol 16, Iss 10, p e1008241 (2020)
In order to assess the efficacy of novel HIV-1 treatments leading to a functional cure, the time to viral rebound is frequently used as a surrogate endpoint. The longer the time to viral rebound, the more efficacious the therapy. In support of such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e2dcd882f247ded63825bfa73c2dca
https://doi.org/10.1101/2020.07.28.221226
https://doi.org/10.1101/2020.07.28.221226
Autor:
Binhua Liang, Jorge F. Correia-Pinto, Yanmin Wan, Hongzhao Li, Lambe Ab, Robert Balshaw, Ma Luo, Francis A. Plummer, Tamara G Dacoba, Mohammad Abul Kashem, James B. Whitney, Dane Schalk, Qingsheng Li, Nikki Toledo, Li L, Lewis R. Liu, Robert W Omange, Liu Xq, José Crecente-Campo, María J. Alonso, Yan Hai, Nancy Schultz-Darken, Su Chi Lim
After over three decades of research, an effective anti-HIV vaccine remains elusive. Unconventional and novel vaccine strategies are needed. Here, we report that a vaccine focusing the immune response on the sequences surrounding the 12 viral proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee39ee59c61d79de56ecaf9cc77fb5f
https://doi.org/10.1101/842955
https://doi.org/10.1101/842955