Zobrazeno 1 - 10
of 49
pro vyhledávání: '"James B. Summers"'
Autor:
Terrance J. Magoc, Yan Guo, Patrick A. Marcotte, George S. Sheppard, Carole L. Goodfellow, Steven K. Davidsen, Lianhong Xu, Alan S. Florjancic, Giesler Jamie, Douglas W. Morgan, Jennifer J. Bouska, Daniel H. Albert, Ildiko Elmore, James B. Summers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3251-3256
A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec88b7a967bac3f5667f9ff636084372
https://doi.org/10.1016/s0960-894x(98)00597-6
https://doi.org/10.1016/s0960-894x(98)00597-6
Publikováno v:
Tetrahedron Letters. 39:5159-5162
In an effort to develop synthetic procedures for the preparation of 2-substituted 5-azaindoles, the synthesis and cyclization reactions of acetylenic aminopyridines was explored. A novel method for the synthesis of 2-substituted 5-azaindoles via a tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc3a0b0ddca4c9cfaa79fa0ba01e8d1
https://doi.org/10.1016/s0040-4039(98)00986-1
https://doi.org/10.1016/s0040-4039(98)00986-1
Autor:
Conway Rg, H. R. Heyman, Denissen Jf, George S. Sheppard, George M. Carrera, Douglas W. Morgan, T. J. Magoc, Daniel H. Albert, Lianhong Xu, Florjancic As, Steven K. Davidsen, Michael L. Curtin, Robert B. Garland, Douglas H. Steinman, Paul Tapang, Luo G, Rhein Da, James B. Summers, Trautmann Ja, Kennan C. Marsh
Publikováno v:
Journal of Medicinal Chemistry. 41:74-95
Studies conducted with the goal of discovering a second-generation platelet-activating factor (PAF) antagonist have identified a novel class of potent and orally active antagonists which have high aqueous solubility and long duration of action in ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a87f7d36ac474f481924621ee6e2a6
https://doi.org/10.1021/jm970389+
https://doi.org/10.1021/jm970389+
Autor:
H. D. Kleinert, T. J. Magoc, George W. Carter, Douglas W. Morgan, S. D. Menacherry, James B. Summers, E. Sun, A. E. Reyes, Daniel H. Albert
Publikováno v:
Inflammation Research. 46:272-277
Objective and Design: ABT-299 is a prodrug that is converted by serum esterase to a potent platelet activating factor (PAF) antagonist (A-85783). In order to evaluate the pharmacological activity of this antagonist in man the effect of ABT-299 given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab004a283c5d80b5d1a082c6780c5689
https://doi.org/10.1007/s000110050186
https://doi.org/10.1007/s000110050186
Autor:
James B. Summers, Jeffrey E. Grossman, Daniel H. Albert, Jerry J. Zimmerman, George W. Carter, Kris T. Kruse-Elliott
Publikováno v:
Shock. 5:265-273
The role of platelet-activating factor (PAF) as a mediator of endotoxin-induced pathophysiology has been studied in several animal models with conflicting results. We evaluated the effect of a new, potent, and specific PAF receptor antagonist, ABT-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8defbdee56c3f65c06278d849f0594e
https://doi.org/10.1097/00024382-199604000-00006
https://doi.org/10.1097/00024382-199604000-00006
Autor:
Terrance J. Magoc, Richard G. Conway, Douglas H. Steinman, Daisy Pireh, Michael L. Curtin, James H. Holms, James B. Summers, H. Robin Heyman, Steven K. Davidsen, Paul Tapang, Daniel H. Albert, George M. Carrera, George S. Sheppard, Rhein Da
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2913-2918
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1H-3H-pyrrolo[1,2-c]thiazoles represent a class of potent, orally active PAF antagonists; however, the lead compounds in this series suffered from a lack of aqueous solubility. To overcome this limitation, a num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f13f4772af4862d22906eb73903181
https://doi.org/10.1016/0960-894x(95)00511-q
https://doi.org/10.1016/0960-894x(95)00511-q
Autor:
Terrance J. Magoc, Daisy Pireh, George S. Sheppard, H. Robin Heyman, Richard G. Conway, Douglas H. Steinman, James H. Holms, Steven K. Davidsen, Rhein Da, Gongjin Luo, George M. Carrera, Nichael L. Curtin, James B. Summers, Paul Tapang, Daniel H. Albert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2903-2908
3-(3-Pyridinyl)-7-(indol-3-ylcarbonyl)-1 H -3 H -pyrrolo[1,2-c]thiazoles represent a new class of platelet activating factor antagonists. This series was discovered by combining the indole portion of a previous thiazolidine series with the known 3-py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588d2ed92275742c29377dbac13be3ca
https://doi.org/10.1016/0960-894x(95)00509-r
https://doi.org/10.1016/0960-894x(95)00509-r
Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Inhibitors of TNFα synthesis
Autor:
James B. Summers, Steven K. Davidsen
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:1087-1100
Tumour necrosis factor-α (TNFα) is a cytokine with a multitude of biological activities linked to the pathology of inflammation. Current anti-TNFα strategies include several protein-based approaches, one of which has produced positive results in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3257a4f367b029b8a8007bbe73146e88
https://doi.org/10.1517/13543776.5.10.1087
https://doi.org/10.1517/13543776.5.10.1087
Publikováno v:
Current Pharmaceutical Design. 1:161-190
Platelet Activating Factor (PAF) is a D-glycerol-derived phospholipid which is a potent endogenous mediator of inflammation. PAF is synthesized and released by a variety of cell types and elicits its biological activity by interacting with specific G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ac6a2001fa20be9f009caa3e70472d
https://doi.org/10.2174/1381612801666220917215816
https://doi.org/10.2174/1381612801666220917215816
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1097-1102
Conformationally constrained analogues of platelet activating factor incorporating various combinations of a lipophile and a pyridine-like heterocycle via hydrogen bond acceptors such as ether and/or carbamate linked to a suitable core group such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eaace8cf1c6aea5d2c78cb9651cdac8
https://doi.org/10.1016/0960-894x(95)00174-r
https://doi.org/10.1016/0960-894x(95)00174-r