Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James B. Springer"'
Publikováno v:
The Journal of organic chemistry. 64(14)
New photochemically removable protecting groups have been developed based on classical nitrobenzyl compounds modified by the inclusion of a pentadienyl group. It serves to trap through an internal Diels-Alder reaction the nitroso group produced as pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34ce0e87ecf8d043044c83b61dc5e85
https://pubmed.ncbi.nlm.nih.gov/34237832
https://pubmed.ncbi.nlm.nih.gov/34237832
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:110-114
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic oxidations at the exocyclic α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6123767b88270a99d9438e99a74af73e
https://doi.org/10.1002/jlcr.3142
https://doi.org/10.1002/jlcr.3142
Autor:
Michael P. Gamcsik, Rebecca L. Mutesi, Michael A. D'Alessandro, James B. Springer, Prince N. A. Amoyaw, Collin R. Dempsey, Susan M. Ludeman
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:607-612
Effects of neurodegeneration have been linked to inefficient detoxification of free radicals due to lowered concentrations of antioxidants, especially glutathione, in the brain. In the biosynthesis of glutathione, cysteine concentration is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42adbdc33a51bc82b545db05dfa3833d
https://doi.org/10.1002/jlcr.1904
https://doi.org/10.1002/jlcr.1904
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:115-122
A variety of deuterated 3-amino-1-propanols were made by the LiAlD 4 or AlD 3 reduction of nitrile or ester precursors. The labeled aminopropanols and/or deuterated bis(2-chloroethyl)amines were used to synthesize [4,4- 2 H 2 ]-, [6,6- 2 H 2 ]-, [α,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570156c4e3b43b926dd3d79bf6bb32b3
https://doi.org/10.1002/jlcr.1182
https://doi.org/10.1002/jlcr.1182
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:79-84
Reduction of diethyliminodiacetate with [ 3 H]-LiAlH 4 and then reaction with SOCl 2 gave bis(2-chloro-2-[ 3 H] ethyl)amine hydrochloride. This compound, together with [ 33 P]-phosphorus oxychloride, provided for the synthesis of [ 3 H, 33 P]-phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3a5c245fec4f8af8fdc272218c16b6
https://doi.org/10.1002/jlcr.1157
https://doi.org/10.1002/jlcr.1157
Autor:
Susan M. Ludeman, Mihir C. Gandhi, M. Eileen Dolan, Sonali M. Smith, Lynette R. Wilson, James B. Springer
Publikováno v:
Cancer Chemotherapy and Pharmacology. 52:291-302
O6-benzylguanine (BG) is a unique purine analog that has been shown to influence nitrogen mustard activity and increase cytotoxicity. Ifosfamide is a nitrogen mustard with growing clinical applications; effective modulation may lead to improved effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1020ac196df964a6ebc29fc1f3ea00df
https://doi.org/10.1007/s00280-003-0672-2
https://doi.org/10.1007/s00280-003-0672-2
Autor:
Michael P. Gamcsik, Kai-Liu Shao, Susan M. Ludeman, O. Michael Colvin, David J. Adams, James B. Springer, Jila H. Boal, James L. Flowers
Publikováno v:
Cancer Chemotherapy and Pharmacology. 45:335-344
A number of investigators have observed that the use of 4-hydroperoxycyclophosphamide (4-HC) in multiwell plate cytotoxicity assays can be associated with toxicity to cells in wells that contain no drug. Previous reports have implicated diffusion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed720d964d5f54b97ef7f46e2338a94e
https://doi.org/10.1007/s002800050049
https://doi.org/10.1007/s002800050049
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 57(2)
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic oxidations at the exocyclic α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b72c31c1232078508a46bc471f083c1
https://pubmed.ncbi.nlm.nih.gov/24307455
https://pubmed.ncbi.nlm.nih.gov/24307455
Publikováno v:
The Journal of Organic Chemistry. 61:1436-1442
In order to determine the reactive geometries of enone−TiCl4 complexes in Diels−Alder reactions compounds 1a·TiCl4 and 1b·TiCl4 were prepared. A crystal structure of 1a·TiCl4 confirmed that the titanium in this complex has the desired out-of-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16ab03b36e2f6128974b0e51677c5c90
https://doi.org/10.1021/jo9518112
https://doi.org/10.1021/jo9518112
Autor:
Robert C. Corcoran, James B. Springer
Publikováno v:
The Journal of Organic Chemistry. 61:1443-1448
Reaction of diastereomeric β-benzyloxy enones with TiCl4 results in the cleavage of the benzyl ethers and yields substrates for Diels−Alder reactions which incorporate covalently attached Lewis acids. The axial CH2OTiCl3 group of 2a unambiguously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614c41141bfc791e51c9d377957ea57d
https://doi.org/10.1021/jo9518922
https://doi.org/10.1021/jo9518922