Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James B. Nold"'
Autor:
Jack P. Chism, Melissa C. Rhodes, Holly L. Jordan, Michael P. Quaile, James B. Nold, David H. Melich, Joseph W. Polli, Glenn Smith
Publikováno v:
Toxicology and Applied Pharmacology. 243:340-347
Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. New treatment options for T2D will likely inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efedc2fbe200ecaf78166a8ef38d181f
https://doi.org/10.1016/j.taap.2009.11.026
https://doi.org/10.1016/j.taap.2009.11.026
Autor:
Paul C Francis, Masahiko Sato, Yanfei Linda Ma, John L. Vahle, Michael Westmore, Jeffery A. Engelhardt, Gerald G. Long, James B. Nold, Jamie K. Young
Publikováno v:
Toxicologic Pathology. 30:312-321
Fischer 344 rats (60/sex/group) were given daily subcutaneou s injections of recombinant human parathyroi d hormone (PTH)(1-34) for 2 years at doses of 0, 5, 30, or 75 μg/kg. Treatment caused substantial increases in bone mass consistent with the kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f32ca5cc9fc10efebbfaa1f6a9f9fcb
https://doi.org/10.1080/01926230252929882
https://doi.org/10.1080/01926230252929882
Publikováno v:
Toxicologic Pathology. 30:178-187
Elmiron, a highly sulfated, semisynthetic pentose polysaccharide with properties similar to heparin, is used for the treatment of interstitial cystitis. Thirteen-week gavage studies were conducted by administering the drug in deionized water to F344/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a584c375acde89d2cd7b06502e034100
https://doi.org/10.1080/019262302753559515
https://doi.org/10.1080/019262302753559515
Autor:
James B. Nold, Roger H. Brown, Richard T. Miller, Julie C. Holder, Holly L. Jordan, John M. Cullen, Daniela Ennulat, James R. Hailey
Publikováno v:
Toxicologic pathology. 42(5)
Whether biliary proliferative lesions in nonclinical species are predictive of potential hepatotoxicity in humans depends, at least in part, on the nature and severity of such changes in the nonclinical species. We reviewed published literature (clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880e3a4f4d3336975f0cab8a49b22fb9
https://pubmed.ncbi.nlm.nih.gov/23960163
https://pubmed.ncbi.nlm.nih.gov/23960163
Publikováno v:
Experimental Biology and Medicine. 201:180-191
Soluble glucan, an immunomodulator, and Walter Reed (WR)-2721, a radioprotectant, increase postirradiation survival when administered before and after exposure, respectively. Combined, these agents act synergistically through WR-2721's ability to spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f218c93efee983d12958e00a0b2c2429
https://doi.org/10.3181/00379727-201-43497
https://doi.org/10.3181/00379727-201-43497
Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy
Autor:
John V. Wade, Henry G. Wall, James B. Nold, Nancy K. Jaax, Denver D. Marlow, Isaac J. Hayward
Publikováno v:
Journal of the Neurological Sciences. 98:99-106
Two benzodiazepine compounds, midazolam and diazepam, were administered as adjunctive treatment to soman-exposed rhesus monkeys to evaluate their effects on acute soman intoxication. Monkeys were pretreated orally with pyridostigmine, exposed to soma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5a6400a7e6d0c121cffd7452019b81
https://doi.org/10.1016/0022-510x(90)90185-p
https://doi.org/10.1016/0022-510x(90)90185-p
Publikováno v:
Drug and Chemical Toxicology. 13:229-239
In all species previously studied, inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period. The sheep is an anatomically unique animal in which to study the development of pulmonary edema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adb4d38b71c5eee8c0b85cd8d8defbc
https://doi.org/10.3109/01480549009018123
https://doi.org/10.3109/01480549009018123
Publikováno v:
Inhalation Toxicology. 2:391-406
Inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period. The sheep is an anatomically suitable animal in which to study the development of pulmonary edema during that symptom-free period.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1deb22ee20213b3cb25cd6f7aa6f7638
https://doi.org/10.3109/08958379009145265
https://doi.org/10.3109/08958379009145265
Autor:
Michael J. Santostefano, James B. Nold, Debie J. Hoivik, Richard T. Miller, Henry G. Wall, Jane Allen
Publikováno v:
International journal of toxicology. 24(5)
Studies conducted under the auspices of International Life Sciences Institute (ILSI) have suggested that an alternative mouse carcinogenicity study may be substituted for the traditional 2-year mouse bioassay typically conducted to support the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc63eeaa38a4cbbae850196633a1aef6
https://pubmed.ncbi.nlm.nih.gov/16257854
https://pubmed.ncbi.nlm.nih.gov/16257854
Autor:
Timothy J. Raczniak, Ronald D. Tyler, Thomas A. Brodie, Ruth M. Lightfoot, Chandikumar S. Elangbam, James B. Nold, H. Roger Brown, Henry G. Wall
Publikováno v:
Toxicologic pathology. 30(4)
We describe and discuss microscopic findings in the brown adipose tissue (BAT) blood vessels of Han Wistar rats treated with GI262570X, a peroxisome proliferator-activated receptor- γ agonist (PPAR- γ agonist) by oral gavage for 28 days, 13 weeks,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3360eaa0baedaf25ea9cd3d8e7324d
https://pubmed.ncbi.nlm.nih.gov/12187934
https://pubmed.ncbi.nlm.nih.gov/12187934