Zobrazeno 1 - 10
of 48
pro vyhledávání: '"James B. Mangum"'
Autor:
Steven J. Novick, Julie B. Stimmel, George W. Rogers, David A. Ferrick, James B. Mangum, Kennedy L. Queen, Ruolan Wang
Publikováno v:
SLAS Discovery. 20:422-429
Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged with identifying mitochondrial liabilities earlier in drug development and thereby reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba141130cca7f77b268b7e62ac44cd0d
https://doi.org/10.1177/1087057114557621
https://doi.org/10.1177/1087057114557621
Autor:
E. E. Reverdy, James B. Mangum, Jeffrey I. Everitt, Bahman Asgharian, Brian A. Wong, Edilberto Bermudez
Publikováno v:
Inhalation toxicology. 12
Elevation of protein carbonyls has been implicated in the clinical setting as a result of oxidant damage associated with a number of disease states in both humans and laboratory animals. Protein carbonyls, the product of oxidative modification of ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c759f48bfa05abfa6923250bd788925b
https://pubmed.ncbi.nlm.nih.gov/26368627
https://pubmed.ncbi.nlm.nih.gov/26368627
Autor:
Brenda Faiola, Diane J. Abernethy, Leslie Recio, James B. Mangum, Alison K. Bauer, Elizabeth S Fuller, Victoria A. Wong, Linda J. Pluta, Jeffrey I. Everitt
Publikováno v:
Toxicological Sciences. 75:321-332
Benzene, a carcinogen that induces chromosomal breaks, is strongly associated with leukemias in humans. Possible genetic determinants of benzene susceptibility include proteins involved in repair of benzene-induced DNA damage. The catalytic subunit o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb61f1b83e4c1158b53e37b3b1baae4
https://doi.org/10.1093/toxsci/kfg186
https://doi.org/10.1093/toxsci/kfg186
Publikováno v:
Toxicological Sciences. 74:165-173
Interspecies differences in pulmonary and pleural responses to the inhalation of natural mineral and synthetic vitreous fibers have been observed in chronic and subchronic studies. However, the reasons for these differences are not clearly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9458e6e711751746ae3fa52698ffcb08
https://doi.org/10.1093/toxsci/kfg092
https://doi.org/10.1093/toxsci/kfg092
Publikováno v:
Toxicological Sciences. 72:331-338
Epidemiological studies have indicated that exposure to elevated levels of particulate matter exacerbates several pulmonary diseases, including asthma, bronchitis, and viral infections. Respiratory syncytial virus (RSV) is the major cause of bronchio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99d90539146916121d5740bc453660d
https://doi.org/10.1093/toxsci/kfg031
https://doi.org/10.1093/toxsci/kfg031
Publikováno v:
Experimental Lung Research. 29:277-290
Pleural inflammation is a sequela of exposure to toxic mineral fibers such as amosite asbestos. This inflammatory response involves the influx of leukocytes from the vasculature into the pleural space. Adhesion molecules such as intercellular adhesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53c953fe5674aaeba4d8aa2f6d07086
https://doi.org/10.1080/01902140303788
https://doi.org/10.1080/01902140303788
Autor:
Edward E. Reverdy, Paul M. Hext, Brian A. Wong, James B. Mangum, David B. Warheit, Bahman Asgharian, Derek B. Janszen, Jeffrey I. Everitt, Edilberto Bermudez
Publikováno v:
Toxicological Sciences. 70:86-97
Female mice, rats, and hamsters were exposed to 10, 50, or 250 mg/m 3 pigmentary titanium dioxide (p-TiO 2 ) particles for 6 h per day and 5 days per week for 13 weeks with recovery groups held for an additional 4, 13, 26, or 52 weeks postexposure (4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef60d13df2bfd95b443a9a9bb844bbd
https://doi.org/10.1093/toxsci/70.1.86
https://doi.org/10.1093/toxsci/70.1.86
Autor:
T. W. Hesterberg, James B. Mangum, Jeffrey I. Everitt, R. A. Rogers, Georgia A. Hart, G. R. Chase, W C Miiller
Publikováno v:
Inhalation Toxicology. 14:217-246
Two new glasswools were developed for optimal biosolubility in the lung: JM 902, for insulation and filtration; and JM 901F, for standard thermal and acoustical insulation. Both were tested for lung biopersistence and their potential to induce persis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25edafff444ec8ba3dfe4e18d26f4f66
https://doi.org/10.1080/08958370252809022
https://doi.org/10.1080/08958370252809022
Publikováno v:
Chemical Health & Safety. 6:24-27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb086f1605de7b6e875f52060ffe8a3
https://doi.org/10.1016/s1074-9098(99)00023-4
https://doi.org/10.1016/s1074-9098(99)00023-4
Autor:
Derek B. Janszen, Owen R. Moss, Thomas R. Gelzleichter, James B. Mangum, Jeffrey I. Everitt, Edilberto Bermudez, Brian A. Wong
Publikováno v:
Toxicological Sciences. 49:93-101
The present study was designed to determine whether pleural fiber burdens or subchronic pleural fibroproliferative and inflammatory changes can help explain the marked interspecies differences in pleural fibrosis and mesothelioma that are observed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4347be836a15b49136a8a77eac8256
https://doi.org/10.1093/toxsci/49.1.93
https://doi.org/10.1093/toxsci/49.1.93