Zobrazeno 1 - 10
of 20
pro vyhledávání: '"James B. Machamer"'
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Mallory J. Stenslik, Kathleen T. Pagarigan, Aaron B. Bradford, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionBotulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical botulism and the only treatment option is supportive care until neuromuscular functio
Externí odkaz:
https://doaj.org/article/8a9f93deb0aa4fd4ad7ec9376ca356fa
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Sean W. O’Brien, Kyle E. Kelly, Amber C. Altvater, Kathleen T. Pagarigan, Parker B. Dubee, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-14 (2022)
Abstract Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure prophylaxis with antitoxin, the
Externí odkaz:
https://doaj.org/article/217f4bf70c89403a831545108d977f5c
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse B
Externí odkaz:
https://doaj.org/article/96fff58717034b729ab96d902fc0e129
Autor:
Christian Spalthoff, Vincent L. Salgado, Narayanan Balu, Michael D. David, Philip Hehlert, Huazhang Huang, John E. Jones, Ramani Kandasamy, Gabriel A. Knudsen, Katherine R. Lelito, James B. Machamer, Alexandre Nesterov, Michael Tomalski, Gregory D. Wahl, Barbara J. Wedel, Martin C. Göpfert
Publikováno v:
Pest Management Science. 79:1635-1649
Pyridazine pyrazolecarboxamides (PPCs) are a novel insecticide class discovered and optimized at BASF. Dimpropyridaz is the first PPC to be submitted for registration and controls many aphid species as well as whiteflies and other piercing-sucking in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147eb3012592591d7270e408d5cc55ae
https://doi.org/10.1002/ps.7352
https://doi.org/10.1002/ps.7352
Autor:
Christian Spalthoff, Vincent L. Salgado, Narayanan Balu, Michael D. David, Philip Hehlert, Huazhang Huang, John E. Jones, Ramani Kandasamy, Gabriel A. Knudsen, Katherine R. Lelito, James B. Machamer, Alexandre Nesterov, Michael Tomalski, Gregory D. Wahl, Barbara J. Wedel, Martin C. Göpfert
Publikováno v:
Pest Management Science. 79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7aa37122830499b7884d17df61e0475
https://doi.org/10.1002/ps.7484
https://doi.org/10.1002/ps.7484
Autor:
Sarah E Wolfe, Kevin M. Bounader, Kathleen T Pagarigan, Patrick M. McNutt, Michael Adler, Shane A. Kasten, James P. Apland, James B. Machamer, Brittany M. Winner
Publikováno v:
Archives of Toxicology. 94:3877-3891
Organophosphorus (OP) compounds inhibit central and peripheral acetylcholinesterase (AChE) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00c2939a0790c97d246cc7231b2d787e
https://doi.org/10.1007/s00204-020-02858-4
https://doi.org/10.1007/s00204-020-02858-4
Autor:
Cesar H. Benjumea, James B. Machamer, Elliot J. Glotfelty, Charles B. Shoemaker, Patrick M. McNutt, Christopher A. Angeles, Luis Tenezaca, Kyle E.M. Kelly, Justin T. Whitfield, Jaclyn Cika, Celinia A. Ondeck, Edwin J. Vazquez-Cintron, Konstantin Ichtchenko, Mark Mangkhalakhili, Philip A. Band
Publikováno v:
Sci Transl Med
Botulism is caused by a potent neurotoxin that blocks neuromuscular transmission, resulting in death by asphyxiation. Currently, the therapeutic options are limited and there is no antidote. Here, we harness the structural and trafficking properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd54bd4a022d1dd0f17924d1b4d24b03
https://doi.org/10.1126/scitranslmed.abd7789
https://doi.org/10.1126/scitranslmed.abd7789
Autor:
James B, Machamer, James P, Apland, Brittany M, Winner, Sarah E, Wolfe, Kathleen T, Pagarigan, Kevin M, Bounader, Shane A, Kasten, Michael, Adler, Patrick M, McNutt
Publikováno v:
Archives of toxicology. 94(11)
Organophosphorus (OP) compounds inhibit central and peripheral acetylcholinesterase (AChE) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e5c02a129e526b16859c869987e33c3
https://pubmed.ncbi.nlm.nih.gov/32691075
https://pubmed.ncbi.nlm.nih.gov/32691075
Autor:
Kathleen T Pagarigan, James B. Machamer, Patrick M. McNutt, Edwin J. Vazquez-Cintron, Brittany M. Winner, Kyle E.M. Kelly, Celinia A. Ondeck, M Ross Pennington, Paige M. Bodner
Publikováno v:
JCI Insight. 5
Botulinum neurotoxins (BoNTs) are potent neuroparalytic toxins that cause mortality through respiratory paralysis. The approved medical countermeasure for BoNT poisoning is infusion of antitoxin immunoglobulins. However, antitoxins have poor therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef431b84408e2fa52226982bad560412
https://doi.org/10.1172/jci.insight.132891
https://doi.org/10.1172/jci.insight.132891
Publikováno v:
Brain Research. 1693:55-66
Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). These mutations result in a loss of FUS from the nucleus and the formation of FUS-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dbac4886f25a934a01bf1e9c08169b
https://doi.org/10.1016/j.brainres.2018.03.037
https://doi.org/10.1016/j.brainres.2018.03.037