Zobrazeno 1 - 10
of 54
pro vyhledávání: '"James B. Jaynes"'
Publikováno v:
eLife, Vol 13 (2024)
The chromosomes in multicellular eukaryotes are organized into a series of topologically independent loops called TADs. In flies, TADs are formed by physical interactions between neighboring boundaries. Fly boundaries exhibit distinct partner prefere
Externí odkaz:
https://doaj.org/article/9427adb529d84547857897ac73cfdcf2
Autor:
Xinyang Bing, Wenfan Ke, Miki Fujioka, Amina Kurbidaeva, Sarah Levitt, Mike Levine, Paul Schedl, James B Jaynes
Publikováno v:
eLife, Vol 13 (2024)
Two different models have been proposed to explain how the endpoints of chromatin looped domains (‘TADs’) in eukaryotic chromosomes are determined. In the first, a cohesin complex extrudes a loop until it encounters a boundary element roadblock,
Externí odkaz:
https://doaj.org/article/69f54650950e47cea510ecc8aa1663b4
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009536 (2021)
Several distinct activities and functions have been described for chromatin insulators, which separate genes along chromosomes into functional units. Here, we describe a novel mechanism of functional separation whereby an insulator prevents gene repr
Externí odkaz:
https://doaj.org/article/5b2f01eff46d4912ba4bc20575b339eb
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005889 (2016)
The chromosomes of multicellular animals are organized into a series of topologically independent looped domains. This domain organization is critical for the proper utilization and propagation of the genetic information encoded by the chromosome. A
Externí odkaz:
https://doaj.org/article/591095aa34cb4e999f593a5a623f2344
Autor:
Natalie D. Gehred, Judith A. Kassis, Sandip De, James B. Jaynes, Miki Fujioka, Fountane W Chan
Publikováno v:
Genetics. 216:689-700
Polycomb group (PcG) proteins are an important group of transcriptional repressors that act by modifying chromatin. PcG target genes are covered by the repressive chromatin mark H3K27me3. Polycomb repressive complex 2 (PRC2) is a multiprotein complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b29702d2d63008099c695e21ff0bb51
https://doi.org/10.1534/genetics.120.303642
https://doi.org/10.1534/genetics.120.303642
Autor:
Jeffrey A. Rappaport, Ariana A. Entezari, Adi Caspi, Signe Caksa, Aakash V. Jhaveri, Timothy J. Stanek, Adam Ertel, Joan Kupper, Paolo M. Fortina, Steven B. McMahon, James B. Jaynes, Adam E. Snook, Scott A. Waldman
Sporadic colorectal cancers arise from initiating mutations in APC, producing oncogenic β-catenin/TCF-dependent transcriptional reprogramming. Similarly, the tumor suppressor axis regulated by the intestinal epithelial receptor GUCY2C is among the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d113045e3055dbb4ab42d816b7821f6
http://hdl.handle.net/11573/1617624
http://hdl.handle.net/11573/1617624
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003883 (2013)
Insulators can block the action of enhancers on promoters and the spreading of repressive chromatin, as well as facilitating specific enhancer-promoter interactions. However, recent studies have called into question whether the activities ascribed to
Externí odkaz:
https://doaj.org/article/c502696370814285a16eb4af695fd89c
Autor:
Sandip, De, Natalie D, Gehred, Miki, Fujioka, Fountane W, Chan, James B, Jaynes, Judith A, Kassis
Publikováno v:
Genetics
Polycomb group (PcG) proteins are an important group of transcriptional repressors that act by modifying chromatin. PcG target genes are covered by the repressive chromatin mark H3K27me3. Polycomb repressive complex 2 (PRC2) is a multiprotein complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9f221777c269ff58297664b235c9c77
https://pubmed.ncbi.nlm.nih.gov/32948625
https://pubmed.ncbi.nlm.nih.gov/32948625
Publikováno v:
Nature Genetics
Nature Genetics, 2018, 50 (9), pp.1296-1303. ⟨10.1038/s41588-018-0175-z⟩
Nature genetics
Nature Genetics, 2018, 50 (9), pp.1296-1303. ⟨10.1038/s41588-018-0175-z⟩
Nature genetics
A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation. Here, we combine genome editing and multi-color live imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b02dbb5299573e448f8d25295917438
https://doi.org/10.1038/s41588-018-0175-z
https://doi.org/10.1038/s41588-018-0175-z
Autor:
Ayşe Haruka Açıkbaş, Jian Ming Khor, James B. Jaynes, Charles A. Ettensohn, Jennifer Guerrero-Santoro
Publikováno v:
The Journal of Biological Chemistry
Alx1, a homeodomain-containing transcription factor, is a highly conserved regulator of skeletogenesis in echinoderms. In sea urchins, Alx1 plays a central role in the differentiation of embryonic primary mesenchyme cells (PMCs) and positively regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9376b489810d2c37a666be4b51b57668
https://doi.org/10.1016/j.jbc.2021.100901
https://doi.org/10.1016/j.jbc.2021.100901