Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James B. Coutcher"'
Autor:
William H. Martin, Banavara L. Mylari, Peter J. Oates, James B. Coutcher, Michael C. Linhares, David A. Tess, Michael S. Dina, David A. Beebe, Gregory J. Withbroe, Sandra J Armento, Melissa O'Gorman, William James Zembrowski, Edward L. Conn
Publikováno v:
Journal of Medicinal Chemistry. 48:6326-6339
Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4950c5594f211c33eec4b7093b58b81
https://doi.org/10.1021/jm050462t
https://doi.org/10.1021/jm050462t
Autor:
Peter J. Oates, Jian-Cheng Li, David A. Beebe, R. Matthew Weekly, Day Wesley Warren, Margaret Y. Chu-Moyer, William E. Ballinger, James B. Coutcher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1477-1480
SAR studies on the stereoisomers of CP-470,711 suggested that in vivo epimerization was taking place in rats. Further metabolism studies revealed that no epimerization was occurring in dogs, and that no epimerization was expected in humans. A mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6551e784a1de915bb77401a612c70ed0
https://doi.org/10.1016/s0960-894x(02)00208-1
https://doi.org/10.1016/s0960-894x(02)00208-1
Autor:
Michael S. Dina, Nathaniel S. Brackett, Peter J. Oates, James B. Coutcher, William James Zembrowski, Banavara L. Mylari, David A. Beebe
Publikováno v:
ChemInform. 32
We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a97a560394336e88e2157646e4f2fb
https://doi.org/10.1002/chin.200149121
https://doi.org/10.1002/chin.200149121
Publikováno v:
Diabetes. 55(10)
Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346fb94673910c9d005428580b330ec3
https://pubmed.ncbi.nlm.nih.gov/17003340
https://pubmed.ncbi.nlm.nih.gov/17003340
Autor:
David A. Beebe, James B. Coutcher, William James Zembrowski, Banavara L. Mylari, Peter J. Oates, Gregory J. Withbroe, Edward L. Conn, Nathaniel S. Brackett
Publikováno v:
Bioorganicmedicinal chemistry. 11(19)
Two new templates, (R) 2-hydroxyethyl-pyridine and (R) 2-hydroxyethyl-triazine, were used to design novel sorbitol dehydrogenase inhibitors (SDIs). The design concept included spawning of these templates to function as effective ligands to the cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362bad9374e7958ccde32d601b5ae785
https://pubmed.ncbi.nlm.nih.gov/12951149
https://pubmed.ncbi.nlm.nih.gov/12951149
Autor:
James B. Coutcher, Gregory J. Withbroe, Peter J. Oates, Melissa O'Gorman, Michael S. Dina, Edward L. Conn, William H. Martin, Banavara L. Mylari, William James Zembrowski, David A. Tess, David A. Beebe, Sandra J Armento, Michael C. Linhares
Publikováno v:
Journal of medicinal chemistry. 46(12)
We report here on the discovery path that led to a structurally unprecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably potent oral activity in normalizing elevated sorbitol levels and, more significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a28c635fafc7155bc0c769f30e1bba
https://pubmed.ncbi.nlm.nih.gov/12773033
https://pubmed.ncbi.nlm.nih.gov/12773033
Autor:
Peter J. Oates, Michael C. Linhares, Gregory J. Withbroe, James B. Coutcher, Edward L. Conn, William James Zembrowski, Melissa O'Gorman, Banavara L. Mylari, David A. Beebe
Publikováno v:
Journal of medicinal chemistry. 45(20)
We report here a novel sorbitol dehydrogenase inhibitor, 16, that shows very high oral potency (50 microg/kg) in normalizing elevated fructose levels in the sciatic nerve of chronically diabetic rats and sustained duration of action (24 h). Furthermo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09607f6a1fc5ec3ce9cd426c31c991df
https://pubmed.ncbi.nlm.nih.gov/12238919
https://pubmed.ncbi.nlm.nih.gov/12238919
Autor:
Day Wesley Warren, David A. Beebe, Margaret Y. Chu-Moyer, William E. Ballinger, Peter J. Oates, Banavara L. Mylari, Jiancheng Li, James B. Coutcher, Richard Berger, R. Matthew Weekly
Publikováno v:
Journal of medicinal chemistry. 45(2)
Optimization of a previously disclosed sorbitol dehydrogenase inhibitor (SDI, II) for potency and duration of action was achieved by replacing the metabolically labile N,N-dimethylsulfamoyl group with a variety of heterocycles. Specifically, this eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5caee518d28eff47eac6a0fcdf74b41
https://pubmed.ncbi.nlm.nih.gov/11784155
https://pubmed.ncbi.nlm.nih.gov/11784155
Autor:
Banavara L. Mylari, Peter J. Oates, Michael S. Dina, David A. Beebe, James B. Coutcher, Nathaniel S. Brackett, William James Zembrowski
Publikováno v:
Journal of medicinal chemistry. 44(17)
We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11536313d6e747b0382a72dfa2b8126
https://pubmed.ncbi.nlm.nih.gov/11495581
https://pubmed.ncbi.nlm.nih.gov/11495581