Zobrazeno 1 - 10
of 199
pro vyhledávání: '"James B McMahon"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Yutaka Takebe, Carrie J Saucedo, Garry Lund, Rie Uenishi, Saiki Hase, Takayo Tsuchiura, Norman Kneteman, Koreen Ramessar, D Lorne J Tyrrell, Masayuki Shirakura, Takaji Wakita, James B McMahon, Barry R O'Keefe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64449 (2013)
Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000 chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of the leading causes of hepatocellular carcinoma which was estimat
Externí odkaz:
https://doaj.org/article/c8a6cc18c5d049bf83106bd356cfc590
Autor:
Johanna S Blees, Heidi R Bokesch, Daniela Rübsamen, Kathrin Schulz, Larissa Milke, Magdalena M Bajer, Kirk R Gustafson, Curtis J Henrich, James B McMahon, Nancy H Colburn, Tobias Schmid, Bernhard Brüne
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46567 (2012)
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S
Externí odkaz:
https://doaj.org/article/d43e632908c94f309f8b3b80f01371d2
Autor:
Nancy H. Colburn, Matthew R. Young, Alyson R. Baker, James B. McMahon, Kirk R. Gustafson, Heidi R. Bokesch, Curtis J. Henrich, Moon-Il Kang
Supplementary Fig. S2 from A selective small-molecule nuclear factor-κB inhibitor from a high-throughput cell-based assay for “activator protein-1 hits”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2354cc904311c780a30b8188edd8e9a5
https://doi.org/10.1158/1535-7163.22485156
https://doi.org/10.1158/1535-7163.22485156
Autor:
Nancy H. Colburn, Matthew R. Young, Alyson R. Baker, James B. McMahon, Kirk R. Gustafson, Heidi R. Bokesch, Curtis J. Henrich, Moon-Il Kang
NSC 676914 has been identified as a selective nuclear factor-κB (NF-κB) inhibitor that does not inhibit cell proliferation. This compound was originally identified in a high-throughput cell-based assay for activator protein-1 (AP-1) inhibitors usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b12ffa6bc3a3236946cfc5874e9768
https://doi.org/10.1158/1535-7163.c.6531798.v1
https://doi.org/10.1158/1535-7163.c.6531798.v1
Supplementary Methods, Figures 1-5 from Carminomycin I Is an Apoptosis Inducer That Targets the Golgi Complex in Clear Cell Renal Carcinoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366b258a0b354f56406daf703c56b9c7
https://doi.org/10.1158/0008-5472.22387065.v1
https://doi.org/10.1158/0008-5472.22387065.v1
Autor:
Girma M. Woldemichael, Thomas J. Turbyville, James R. Vasselli, W. Marston Linehan, James B. McMahon
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 771-777 (2012)
Verrucarin A (VA) is a small molecule derived from the fungal plant pathogen Myrothecium verrucaria and was identified as a selective inhibitor of clear cell renal cell carcinoma (CCRCC) cell proliferation in a high-throughput screen of a library of
Externí odkaz:
https://doaj.org/article/672c2e8f8c1241688e9f7c61c59ed12a
Publikováno v:
Planta Medica. 81:S1-S381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe95b4a9c770c17a3042996e34b3150c
https://doi.org/10.1055/s-0036-1596238
https://doi.org/10.1055/s-0036-1596238
Autor:
Andrew K. L. Goey, Leo A. Joyce, Arvin Moser, Tawnya C. McKee, James B. McMahon, Kirk R. Gustafson, Josep Saurí, Scott A. MacDonald, Shabana I. Khan, Wes Schafer, R. Thomas Williamson, Roger R. Nani, Tanya T. Ransom, William D. Figg, Susanna T. S. Chan, Evan A. Schauer, Gary E. Martin, Alexei V. Buevich, Martin J. Schnermann, Curtis J. Henrich
Publikováno v:
The Journal of Organic Chemistry. 81:10631-10640
An extract of Eudistoma sp. provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework. Eudistidine C (1) is a racemic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b5c6e21d8cfe3f10d851479c58413e
https://doi.org/10.1021/acs.joc.6b02380
https://doi.org/10.1021/acs.joc.6b02380
Autor:
Ranjala Ratnayake, Patrick J. Grohar, Emad Darvishi, Girma M. Woldemichael, Thomas J. Turbyville, James B. McMahon, Vittorio Caropreso
Publikováno v:
Journal of Biological Chemistry. 291:10058-10066
High-throughput screening of extracts from plants, marine, and micro-organisms led to the identification of the extract from the plant Phyllanthus engleri as the most potent inhibitor of EWS-FLI1 induced luciferase reporter expression. Testing of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efe55e84d7c5d05830310adb652c965
https://doi.org/10.1074/jbc.m115.701375
https://doi.org/10.1074/jbc.m115.701375