Zobrazeno 1 - 10
of 68
pro vyhledávání: '"James B McLachlan"'
Autor:
Bonnie Douglas, Yun Wei, Xinshe Li, Annabel Ferguson, Li-Yin Hung, Christopher Pastore, Jonathan R Kurtz, James B McLachlan, Thomas J Nolan, James Lok, De'Broski R Herbert
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009709 (2021)
Helminths are distinct from microbial pathogens in both size and complexity, and are the likely evolutionary driving force for type 2 immunity. CD4+ helper T cells can both coordinate worm clearance and prevent immunopathology, but issues of T cell a
Externí odkaz:
https://doaj.org/article/f66ce925c97b46d69a13fbc223b51e37
Autor:
Michelle Galeas-Pena, Allyson Hirsch, Erin Kuang, Joseph Hoffmann, Patrick Gellings, Jasmine B. Brown, Vanessa M. Limbert, Claire L. Callahan, James B. McLachlan, Lisa A. Morici
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Pertussis is a vaccine-preventable respiratory disease caused by the Gram negative coccobacillus Bordetella pertussis. The licensed acellular pertussis (aP) vaccines protect against disease but do not prevent bacterial colonization and trans
Externí odkaz:
https://doaj.org/article/ff82b04918334d96b5a42736516074f4
Autor:
Seung-Joo Lee, James B McLachlan, Jonathan R Kurtz, Danhua Fan, Sebastian E Winter, Andreas J Baumler, Marc K Jenkins, Stephen J McSorley
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002499 (2012)
Pathogens can substantially alter gene expression within an infected host depending on metabolic or virulence requirements in different tissues, however, the effect of these alterations on host immunity are unclear. Here we visualized multiple CD4 T
Externí odkaz:
https://doaj.org/article/1386ede2ca8c4a21bf702e216dbd0749
Autor:
John T. Prior, Vanessa M. Limbert, Rebecca M. Horowitz, Shaina J. D’Souza, Louay Bachnak, Matthew S. Godwin, David L. Bauer, Jaikin E. Harrell, Lisa A. Morici, Justin J. Taylor, James B. McLachlan
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Although most pathogens infect the human body via mucosal surfaces, very few injectable vaccines can specifically target immune cells to these tissues where their effector functions would be most desirable. We have previously shown that cert
Externí odkaz:
https://doaj.org/article/638c80db4344406292b9c8eca00fb6bf
Autor:
Nicholas J. First, Katelyn M. Parrish, Amparo Martínez-Pérez, África González-Fernández, Sushma Bharrhan, Matthew Woolard, James B. McLachlan, Rona S. Scott, Jian Wang, Monica C. Gestal
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113294- (2023)
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting
Externí odkaz:
https://doaj.org/article/1873108fec1342a0bbb5576abc0ed691
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 2, Pp 412-418 (2020)
Pseudomonas aeruginosa is an opportunistic human pathogen capable of causing a wide range of potentially life-threatening infections. With multidrug-resistant P. aeruginosa infections on the rise, the need for a rationally-designed vaccine against th
Externí odkaz:
https://doaj.org/article/ee94469c56ab47e1ae2f7e289b0f3a09
Autor:
David L. Bauer, Louay Bachnak, Vanessa M. Limbert, Rebecca M. Horowitz, Robin L. Baudier, Shaina J. D’Souza, Victoria E. Immethun, Jonathan R Kurtz, Samuel B. Grant, James B. McLachlan
Publikováno v:
The Journal of Immunology. 210:1519-1530
Adjuvants are often essential additions to vaccines that enhance the activation of innate immune cells, leading to more potent and protective T and B cell responses. Only a few vaccine adjuvants are currently used in approved vaccine formulations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567b15401e6c0ec92b73cda639c0e0b5
https://doi.org/10.4049/jimmunol.2200221
https://doi.org/10.4049/jimmunol.2200221
An Outer Membrane Vesicle-Adjuvanted Oral Vaccine Protects Against Lethal, Oral Salmonella Infection
Autor:
Jaikin E. Harrell, Jonathan R. Kurtz, David L. Bauer, J. Timothy Prior, Patrick S. Gellings, Lisa A. Morici, James B. McLachlan
Publikováno v:
Pathogens, Vol 10, Iss 5, p 616 (2021)
Non-typhoidal salmonellosis, caused by Salmonella enterica serovar Typhimurium is a common fecal-oral disease characterized by mild gastrointestinal distress resulting in diarrhea, chills, fever, abdominal cramps, head and body aches, nausea, and vom
Externí odkaz:
https://doaj.org/article/6aef9d7d4536401c8b64aa1b108a6708
Autor:
J. Timothy Prior, Christopher Davitt, Jonathan Kurtz, Patrick Gellings, James B. McLachlan, Lisa A. Morici
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 131 (2021)
Discovery and development of novel adjuvants that can improve existing or next generation vaccine platforms have received considerable interest in recent years. In particular, adjuvants that can elicit both humoral and cellular immune responses would
Externí odkaz:
https://doaj.org/article/83369a6db2504d27a5d8cb8376b51cba
Publikováno v:
Pathogens, Vol 9, Iss 8, p 605 (2020)
Recent thymic emigrants are the youngest subset of peripheral T cells and their involvement in combating persistent bacterial infections has not been explored. Here, we hypothesized that CD4+ recent thymic emigrants are essential immune mediators dur
Externí odkaz:
https://doaj.org/article/de0c57614ad64fecb953b38abf7f547f