Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James Aylward"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1871 (2024)
Many pathogenetic mechanisms have been proposed for amyotrophic lateral sclerosis (ALS). Recently, there have been emerging suggestions of a possible role for the gut microbiota. Gut microbiota have a range of functions and could influence ALS by sev
Externí odkaz:
https://doaj.org/article/35bc4eda57044e66b6cca8145f282559
Autor:
Pamela A. McCombe, Sarah Reed, James Aylward, David V. Pow, Aven Lee, Robert D. Henderson, Buddhika J. Arachchige
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22:206-210
D-serine is an endogenous co-agonist with glutamate for activation of the N-methyl-D-aspartate receptor (NMDAR). D-serine exacerbates neuronal death and is elevated in the spinal cord from patients...
Publikováno v:
Neurodegenerative Diseases. 20:200-206
Objectives: Excitotoxicity is thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). One possible source of excitotoxicity is the presence of sulphur amino acids (SAAs). In the brain of subjects with ALS, there are increas
Autor:
M. Dominik Fischer, Alexandra Davies, Edmond Luo, Cristina Martinez-Fernandez de la Camara, James Aylward, Anna Paola Salvetti, Byron L. Lam, Jasmina Cehajic-Kapetanovic, Potyra R. Rosa, Aniz Girach, Tuyen Ong, Laura J Wood, Jasleen K Jolly, Brandon J. Lujan, Graeme C.M. Black, Alun R. Barnard, Ninel Z. Gregori, Robert E MacLaren, Paulo E. Stanga, Andrew J. Lotery, Anika Nanda, Kanmin Xue, Janet L. Davis
Retinal gene therapy has shown great promise in treating retinitis pigmentosa (RP), a primary photoreceptor degeneration that leads to severe sight loss in young people. In the present study, we report the first-in-human phase 1/2, dose-escalation cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599e0e25ff2a57b4ee69a8de68818190
https://ora.ox.ac.uk/objects/uuid:4e8ab24d-7fab-49f1-993b-3bc234ed1928
https://ora.ox.ac.uk/objects/uuid:4e8ab24d-7fab-49f1-993b-3bc234ed1928
Autor:
Saleha Z. Munir, James Aylward
Publikováno v:
Optometry and Vision Science. 94:545-555
Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic hematopoietic stem cell transplantation, which is a potential curative therapy used in a variety of malignant or benign hematological diseases. Graft-versus-hos
Autor:
Jonathan Wood, Jonathan Brett, Maria I. Patrício, James Aylward, Jasleen K Jolly, Robert E MacLaren, Kirti Madhukar Jasani, Kanmin Xue
Publikováno v:
Ophthalmology. 125:1122-1124
Fundus autofluorescence (AF) arises from lipofuscin, which is derived from retinoid byproducts of the visual cycle and accumulates within retinal pigment epithelial cells. Alterations in AF pattern are seen in a wide range of retinal degenerations. C
Autor:
James M. O’Riordan, Paul McCormick, J. Larkin, Ben Creavin, Brian Mehigan, M.C. Whelan, Paul Neary, Barry Maguire, David Moore, D. Kavanagh, Conor James Aylward, Michael E. Kelly
Publikováno v:
Mesentery and Peritoneum. 5:AB143-AB143
Autor:
Lewis E Fry, Jonathan H. Williams, Maria I. Patrício, Penny Clouston, Robert E MacLaren, Harriet Hewitt, Alun R. Barnard, Kanmin Xue, James Aylward
Publikováno v:
JAMA Ophthalmol
IMPORTANCE: Gene therapy is a promising treatment for choroideremia, an X-linked retinal degeneration. The required minimum level of gene expression to ameliorate degeneration rate is unknown. This can be interrogated by exploring the association bet
Autor:
Buddhika J. Arachchige, Sarah Reed, James Aylward, Aven Lee, Robert D. Henderson, Pamela A. McCombe
Publikováno v:
Journal of the Neurological Sciences. 409:116589
Introduction The aim of this study was to determine whether patients with amyotrophic lateral sclerosis (ALS) exhibit higher plasma levels of formaldehyde (FA) than controls, and to look for alterations in levels of FA precursors. Methods We studied
Publikováno v:
Medical teacher. 40(2)
Dear SirWe were interested to read the piece by Edwards et al. (2017) on motivational interviewing. During the General Practice (GP) rotation at Oxford Medical School, motivational interviewing is ...