Zobrazeno 1 - 9 of 9 pro vyhledávání: '"James Ashcom"'
1
Cloning and characterisation of an aspartyl protease inhibitor (API-1) from Ancylostoma hookworms
Autor: Geeta Varghese, Angela L. Williamson, John M. Hawdon, Andrea Brand, Angela Delaney, Gaddam Goud, James Ashcom
Publikováno v: International Journal for Parasitology. 35:303-313
Hookworm infection persists as a public health problem in developing nations. Vaccine-based strategies offer the best chance of long-term control. Aspartyl protease inhibitors from parasitic nematodes are highly immunogenic, and have been suggested a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32540c8a9e4ec184c22b7d16f7afbaa4
https://doi.org/10.1016/j.ijpara.2004.11.014
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2
Characterization of α-conotoxin interactions with the nicotinic acetylcholine receptor and monoclonal antibodies
Autor: D. James Ashcom, G. Bradley Stiles
Publikováno v: Biochemical Journal. 328:245-250
The venoms of predatory marine cone snails, Conus species, contain numerous peptides and proteins with remarkably diverse pharmacological properties. One group of peptides are the α-conotoxins, which consist of 13-19 amino acids constrained by two d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3343114404aa449114ed2d267d810ac7
https://doi.org/10.1042/bj3280245
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3
Vaccines Against Human Hookworm Disease
Autor: John M. Hawdon, Denis Moss, Donald P. McManus, Steven G. Reed, Farrokh Modabber, P Cleary, Joelle Thonnard, Paul Bartley, J Zabriskie, David Tribble, Shahida Baqar, Peter Collins, Margaret Liu, Carol Baker, Gary Horwith, Roger Glass, Philip K. Russell, Joe Cohen, Thomas Hale, Daniel Scott, Timothy Mietzner, Robert Naso, David Vaughn, David Bernstein, Cynthia Lee, Morven Edwards, Richard Ward, Walter E. Brandt, Myron Levine, Zhan Bin, Sergio Abrignani, Thomas Richie, Paul Offit, Fabrice Godfroid, Stanley Plotkin, Jeffrey M. Bethony, H Sabharwal, Chad Womack, Alex Loukas, Robert Brunham, Danielle Stanisic, William A. Petri, J Robert Putnak, Gary Nabel, Richard Whitley, H Fred Clark, Jan Poolman, Ali Fattom, Peter J. Hotez, Solomon Langermann, James Dale, Lawrence Paoletti, Philippe Sansonetti, W Ripley Ballou, Giuseppe Del Giudice, Alan Schmaljohn, Karen Kotloff, Marcia Hobbs, Niranjan Kanesa-thasan, Philippe Denoel, Brian Murphy, Andre´ Capron, Kashinath Ghosh, Connie Schmaljohn, David Kemp, Antonio Campos-Neto, Robin Anders, Vincent Fischetti, Ce´cile Neyt, James Crowe, Eileen Barry, Laura Martin, Gilles Riveau, Denise L. Doolan, Barney Graham, Joseph McCormick, Christopher Thomas, Myron Cohen, Christopher Huston, Allan Saul, Andrew Murdin, Michael Houghton, K Fuchs, Michael F. Good, James Ashcom, Stephen Hoffman, Mandvi Bharadwaj
Publikováno v: New Generation Vaccines, Fourth Edition ISBN: 9780824740719
New Generation Vaccines, Fourth Edition
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aebd137129cc0f987ae947697e471df5
https://doi.org/10.1201/9781439834404.ch48
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5
Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms
Autor: Mahnaz Badamchian, Peter J. Hotez, Xiao Shuhua, Bin Zhan, Jianjun Feng, Bo Meihua, James Ashcom, John M. Hawdon
Publikováno v: Scopus-Elsevier
A cDNA encoding a putative tissue inhibitor of metalloprotease was cloned from an Ancylostoma caninum adult hookworm cDNA library by immunoscreening with anti-hookworm secretory products antiserum. Ac-TMP (A. caninum tissue inhibitor of metalloprotei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4001082b1cf6a917c50a14af99e19cb1
https://pubmed.ncbi.nlm.nih.gov/12139214
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7
Decline in protease activities with age in the nematode caenorhabditis elegans
Autor: Gary J. Sarkis, John M. Hawdon, Lewis A. Jacobson, James Ashcom
Publikováno v: Mechanisms of Ageing and Development. 45:191-201
The activities of 3 lysosomal proteases in the nematode Caenorhabditis elegans are markedly lower in older animals. The aspartyl protease cathepsin D declines about 10-fold from day 3 (early adulthood) to day 11 (near the mean lifespan); this reflect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fd4b279b34bb534623a623cb9c734e
https://doi.org/10.1016/0047-6374(88)90001-2
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8
Proteases of the nematode Caenorhabditis elegans
Autor: Gary J. Sarkis, James Ashcom, Linda Jen-Jacobson, Michael R. Kurpiewski, Lewis A. Jacobson
Publikováno v: Archives of biochemistry and biophysics. 261(1)
Crude homogenates of the soil nematode Caenorhabditis elegans exhibit strong proteolytic activity at acid pH. Several kinds of enzyme account for much of this activity: cathepsin D, a carboxyl protease which is inhibited by pepstatin and optimally ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeac69986e3710055d74061a36f54bd9
https://pubmed.ncbi.nlm.nih.gov/3277541
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9
Self-quenched fluorogenic protein substrates for the detection of cathepsin D and other protease activities
Autor: Lewis A. Jacobson, James Ashcom
Publikováno v: Analytical biochemistry. 176(2)
Self-quenched fluorogenic substrates for proteolytic enzymes have been prepared by alkylation of thiol groups in reduced bovine serum albumin with iodoacetamidofluorescein or iodoacetamidoeosin. Substrates immobilized by adsorption onto nitrocellulos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9cce33b3c32c00d9a54935d68f112c
https://pubmed.ncbi.nlm.nih.gov/2662807
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