Zobrazeno 1 - 9 of 9 pro vyhledávání: '"James A. Zanghi"'
1
A useful model to compare human and mouse growth hormone gene chromosomal structure, expression and regulation, and immune tolerance of human growth hormone analogues
Autor: Margaret E. Bock, Yan Jin, Peter A. Cattini, James A. Zanghi, Hana Vakili
Publikováno v: Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
Human (h) pituitary growth hormone (GH) is both physiologically and clinically important. GH reaches its highest circulatory levels in puberty, where it contributes to energy homeostasis and somatogenic growth. GH also helps to maintain tissues and o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb76a126f0f4e182a15a091761eef6c
https://pubmed.ncbi.nlm.nih.gov/30227383
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2
Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis
Autor: L. M. Hartkamp, Paul P. Tak, Andrew L. Rankin, James A. Zanghi, Kris A. Reedquist, Inge E. van Es, Timothy R D J Radstake, Haishan Lin, Brian Wong, Justin Wong, Li Long, B Malvar-Fernández, Samuel Garcia, Emma Masteller
Publikováno v: Arthritis Research & Therapy
Arthritis research & therapy, 18(1). BioMed Central
Arthritis Research & Therapy, 18. BioMed Central
Background CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of this study was to determine t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0409381eac3a348da3ac1e072da85220
http://europepmc.org/articles/PMC4818474
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3
The Growth Factor Inhibitor Suramin Reduces Apoptosis and Cell Aggregation in Protein-Free CHO Cell Batch Cultures
Autor: Wolfgang A. Renner, James A. Zanghi, James E. Bailey, Martin Fussenegger
Publikováno v: Biotechnology Progress. 16:319-325
We have previously shown that Chinese hamster ovary (CHO) cells capable of growing in medium free of exogenous proteins die by apoptosis during all stages of a batch culture (Zanghi et al., 1999). On the basis of the hypothesis that extracellular dea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1675e42cc3bffbfa72f725cb4c59611
https://doi.org/10.1021/bp0000353
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4
[Untitled]
Autor: D. Fassnacht, James E. Bailey, Ralf Pörtner, Regine Schwartz, Michael Graf, Martin Fussenegger, James A. Zanghi
Publikováno v: Cytotechnology. 32:45-61
Using multicistronic expression technology we generated a stable Chinese hamster ovary (CHO) cell line (MG12) expressing a model secreted heterologous glycoprotein, the secreted form of the human placental alkaline phosphatase (SEAP), and bcl-2, best
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbbe7d5dfc9ac1da4e10fc51499be720
https://doi.org/10.1023/a:1008168522385
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5
Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH
Autor: Richard H. Knop, Albert E. Schmelzer, Thomas P. Mendoza, William M. Miller, James A. Zanghi
Publikováno v: Biotechnology and Bioengineering. 65:182-191
Accumulation of CO(2) in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals. By examining the cell-surface polysialic acid (PSA) content, we show that elevated CO(2) partial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::083940ef148a76ae2e92ef1ad2ea9243
https://doi.org/10.1002/(sici)1097-0290(19991020)65:2<182::aid-bit8>3.0.co
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6
Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture
Autor: James E. Bailey, James A. Zanghi, Martin Fussenegger
Publikováno v: Biotechnology and Bioengineering. 64:108-119
The development of serum- and protein-free Chinese hamster ovary (CHO) cell cultures is a high priority for the production of biopharmaceuticals. Protein-free competent CHO cells lines have been previously constructed by two different methods—metab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7aee33c0f01be66ce876a4b3952aa9da
https://doi.org/10.1002/(sici)1097-0290(19990705)64:1<108::aid-bit12>3.0.co
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8
Role of nucleotide sugar pools in the inhibition of NCAM polysialylation by ammonia
Autor: Richard H. Knop, Albert E. Schmelzer, William M. Miller, James A. Zanghi, Thomas P. Mendoza
Publikováno v: Biotechnology progress. 14(6)
Ammonia in animal cell cultures has been shown to specifically inhibit terminal sialylation of N- and O-linked oligosaccharides of glycoproteins. For example, we have previously shown that as little as 2.5 mM NH 4 Cl can decrease neural cell adhesion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66babfbc00e1189355d2223bd02c7d85
https://pubmed.ncbi.nlm.nih.gov/9841644
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9
Discrimination of fluorinated uridine metabolites in N-417 small cell lung cancer cell extracts via 19F- and 31P-NMR
Autor: Richard H. Knop, William M. Miller, James A. Zanghi, Nathanael V. Pederson
Publikováno v: Magnetic resonance in medicine. 31(2)
31 P-NMR extract spectra of N-417 Small Cell Lung Cancer (SCLC) cells cultured with fluorouridine (FUrd) reveal new peaks with chemical shifts in the diphosphodiester and nucleoside triphosphate regions. These peaks were identified as FUTP, FUDP, FUD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6b6acbb15f7dd88a81ecdeea29877f
https://pubmed.ncbi.nlm.nih.gov/8133759
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