Zobrazeno 1 - 10
of 296
pro vyhledávání: '"James A. Wohlschlegel"'
Autor:
Lisa Ta, Brandon L. Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Wendy Tran, James A. Wohlschlegel, Janai R. Carr-Ascher, Owen N. Witte
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108480- (2023)
Summary: Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms
Externí odkaz:
https://doaj.org/article/50c08eec40e64d8eaf3c2bad01473b66
Autor:
Zhenhui Zhong, Yan Xue, C. Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A. Wohlschlegel, Steven E. Jacobsen
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, whe
Externí odkaz:
https://doaj.org/article/36717267e0554e1a8f34782f596b8a07
Autor:
Amara C. Thind, Caroline M. Mota, Ana Paula N. Gonçalves, Jihui Sha, James A. Wohlschlegel, Tiago W. P. Mineo, Peter J. Bradley
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Toxoplasma gondii’s propensity to infect its host and cause disease is highly dependent on its ability to modulate host cell functions. One of the strategies the parasite uses to accomplish this is via the export of effector proteins from
Externí odkaz:
https://doaj.org/article/068f287a774640d587813763274178e3
Autor:
Zhenhui Zhong, Yafei Wang, Ming Wang, Fan Yang, Quentin Angelo Thomas, Yan Xue, Yaxin Zhang, Wanlu Liu, Yasaman Jami-Alahmadi, Linhao Xu, Suhua Feng, Sebastian Marquardt, James A. Wohlschlegel, Israel Ausin, Steven E. Jacobsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.
Externí odkaz:
https://doaj.org/article/48f202d094e446e09e9606a9f5b188d8
Autor:
Shilpa Hebbar, Ganesh Panzade, Ajay A. Vashisht, James A. Wohlschlegel, Isana Veksler-Lublinsky, Anna Y. Zinovyeva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract microRNAs (miRNAs) are crucial for normal development and physiology. To identify factors that might coordinate with miRNAs to regulate gene expression, we used 2′O-methylated oligonucleotides to precipitate Caenorhabditis elegans let-7, m
Externí odkaz:
https://doaj.org/article/0d21b2655acd4ddb94d7327df8708ac2
Autor:
Peter S. Back, Andy S. Moon, Rebecca R. Pasquarelli, Hannah N. Bell, Juan A. Torres, Allan L. Chen, Jihui Sha, Ajay A. Vashisht, James A. Wohlschlegel, Peter J. Bradley
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The Toxoplasma inner membrane complex (IMC) is a unique organelle that plays critical roles in parasite motility, invasion, egress, and replication. The IMC is delineated into the apical, body, and basal regions, defined by proteins that loc
Externí odkaz:
https://doaj.org/article/85821a7e05bd4ee997f0826bc219e1e4
Autor:
Mohitkumar R. Gangwani, Joselyn S. Soto, Yasaman Jami-Alahmadi, Srushti Tiwari, Riki Kawaguchi, James A. Wohlschlegel, Baljit S. Khakh
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111953- (2023)
Summary: Huntington’s disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts, including in striatal neurons and astrocytes. It is unknown
Externí odkaz:
https://doaj.org/article/869bb4396df64da0aeaf72153dba94a7
Autor:
Chibuike David Obi, Harry A. Dailey, Yasaman Jami-Alahmadi, James A. Wohlschlegel, Amy E. Medlock
Publikováno v:
Life, Vol 13, Iss 2, p 577 (2023)
Heme is an essential cofactor for multiple cellular processes in most organisms. In developing erythroid cells, the demand for heme synthesis is high, but is significantly lower in non-erythroid cells. While the biosynthesis of heme in metazoans is w
Externí odkaz:
https://doaj.org/article/fef55fd4c8ec4d3392a2e520ba35cd14
Autor:
Yadi Chen, Xiaohua Hu, Siyuan Liu, Tiantian Su, Hsiaochi Huang, Huibo Ren, Zhensheng Gao, Xu Wang, Deshu Lin, James A. Wohlschlegel, Qin Wang, Chentao Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The fate of proteins in cells is determined by not only synthesis but also degradation. Here Chen et al. show that degradation of the plant blue light receptor CRY2 is determined by two distinct E3 ubiquitin ligases, Cul4COP1/SPAs and Cul3LRBs, regul
Externí odkaz:
https://doaj.org/article/433915f079e646c48c5a0e595d94b622
Autor:
Gabriele Colozza, Yasaman Jami-Alahmadi, Alyssa Dsouza, Nydia Tejeda-Muñoz, Lauren V. Albrecht, Eric A. Sosa, James A. Wohlschlegel, Edward M. De Robertis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes. We have proposed that seque
Externí odkaz:
https://doaj.org/article/70bc8e647cea4e6a97568c3d15403f70