Zobrazeno 1 - 10
of 39
pro vyhledávání: '"James A. Van Deventer"'
Autor:
Rafael Alcala-Torano, Mariha Islam, Jaclyn Cika, Kwok Ho Lam, Rongsheng Jin, Konstantin Ichtchenko, Charles B. Shoemaker, James A. Van Deventer
Publikováno v:
ACS Chemical Biology. 17:3435-3449
While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe the use of yeast displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b094ba1c5aeaf7f431722bd973f78c4a
https://doi.org/10.1021/acschembio.2c00574
https://doi.org/10.1021/acschembio.2c00574
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007779 (2020)
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of ant
Externí odkaz:
https://doaj.org/article/276daf1e920a46ca96b24b04ed0cd0c7
Publikováno v:
ACS Synthetic Biology. 11:3669-3680
Numerous applications of noncanonical amino acids (ncAAs) in basic biology and therapeutic development require efficient protein biosynthesis using an expanded genetic code. However, achieving such incorporation at repurposed stop codons in cells is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9e5846cc4f450cdaa70fdfe8985a6a
https://doi.org/10.1021/acssynbio.2c00267
https://doi.org/10.1021/acssynbio.2c00267
Autor:
Manjie Huang, Marina Rueda-Garcia, Abbigael Harthorn, Benjamin J. Hackel, James A. Van Deventer
Protein-small molecule hybrids are structures that have the potential to combine the inhibitory properties of small molecules and the specificities of binding proteins. However, achieving such synergies is a substantial engineering challenge, with fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5151a5a6981311d363cb4ff80d82f618
https://doi.org/10.1101/2023.05.12.540568
https://doi.org/10.1101/2023.05.12.540568
Publikováno v:
ACS Synth Biol
Archaeal pyrrolysyl-tRNA synthetases (PylRSs) have been used to genetically encode over 200 distinct noncanonical amino acids (ncAAs) in proteins in E. coli and mammalian cells. This vastly expands the range of chemical functionality accessible withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac58a276c72bac336a422f90d5b17c6
https://doi.org/10.1021/acssynbio.2c00001
https://doi.org/10.1021/acssynbio.2c00001
Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface
Publikováno v:
Protein Engineering, Design and Selection. 36
Display technologies are powerful tools for discovering antibodies and other binding proteins against a broad range of biological targets. However, it remains challenging to adapt display technologies for the discovery of proteins that inhibit the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39da3780bce26467aa5f382c2513321a
https://doi.org/10.1093/protein/gzac017
https://doi.org/10.1093/protein/gzac017
Publikováno v:
ACS Synth Biol
Genetic code expansion is a powerful approach for advancing critical fields such as biological therapeutic discovery. However, the machinery for genetically encoding noncanonical amino acids (ncAAs) is only available in limited plasmid formats, const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba9a090599b97aede4350bde64c5d85
https://doi.org/10.1021/acssynbio.1c00370
https://doi.org/10.1021/acssynbio.1c00370
SummaryIncorporation of more than one non-canonical amino acid (ncAA) within a single protein endows the resulting construct with multiple useful features such as augmented molecular recognition or covalent crosslinking capabilities. Herein, for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51951e227d99d29b881a1cb6e269bf23
https://doi.org/10.1101/2022.10.19.512873
https://doi.org/10.1101/2022.10.19.512873
Publikováno v:
Biotechnology and bioengineeringREFERENCES.
Synthetic cell-cell interaction systems can be useful for understanding multicellular communities or for screening binding molecules. We adapt a previously characterized set of synthetic cognate nanobody-antigen pairs to a yeast-bacteria coincubation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b70162a388f876e234283090b840755
https://pubmed.ncbi.nlm.nih.gov/36259110
https://pubmed.ncbi.nlm.nih.gov/36259110
Publikováno v:
Annu Rev Biomed Eng
The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds with potentially attractive therapeutic properties, including the ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba86e74dca29cd758404be7f6e2883
https://doi.org/10.1146/annurev-bioeng-010220-095711
https://doi.org/10.1146/annurev-bioeng-010220-095711