Zobrazeno 1 - 7
of 7
pro vyhledávání: '"James A. Tonkin"'
Autor:
James A. Tonkin, Ume-Kulsoom Shah, Shareen H. Doak, M. R. Brown, Katherine E. Chapman, George E. Johnson, Eleanor C. Wilde, Gareth J.S. Jenkins, Jatin R Verma
Publikováno v:
Mutagenesis. 35:445-452
In vitro genotoxicity studies are a quick and high throughput approach to assess the genotoxic potential of chemicals; however, the reliability of these tests and their relevance to in vivo effects depends on the choice of representative cell line an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755356f16ce5a2d98c3ba5d94c14241
https://doi.org/10.1093/mutage/geaa029
https://doi.org/10.1093/mutage/geaa029
Autor:
Ann T. Doherty, George E. Johnson, Fiona M. Chapman, Katherine E. Chapman, Jatin R. Verma, Eleanor C. Wilde, James A. Tonkin, Leanne M. Stannard, Gareth J.S. Jenkins, M. Rowan Brown, Ume-Kulsoom Shah, Anna L. Seager, Shareen H. Doak
Publikováno v:
Archives of Toxicology
Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a23b0c49eed7468aa74bcdecf69813
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
Autor:
James A Tonkin, Paul Rees, Martyn R Brown, Rachel J Errington, Paul J Smith, Sally C Chappell, Huw D Summers
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40835 (2012)
An automated technique for the identification, tracking and analysis of biological cells is presented. It is based on the use of nanoparticles, enclosed within intra-cellular vesicles, to produce clusters of discrete, point-like fluorescent, light so
Externí odkaz:
https://doaj.org/article/9eca5d7beb7146dcb8f31eeb9942ddd4
Autor:
George E. Johnson, Katherine E. Chapman, Katja Brüsehafer, Gareth J.S. Jenkins, M. Rowan Brown, Jatin R. Verma, Ume-Kulsoom Shah, Leanne M. Stannard, Eleanor C. Wilde, Shareen H. Doak, Anna L. Seager, James A. Tonkin, Ann T. Doherty
Publikováno v:
Archives of Toxicology
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d5058ecc28a1ac7797ee5faa9135b
https://doi.org/10.1007/s00204-017-2102-y
https://doi.org/10.1007/s00204-017-2102-y
Autor:
Andy Brown, M. Rowan Brown, Nicole Hondow, Rik Brydson, Mark D. Holton, James A. Tonkin, John W. Wills, Huw D. Summers, Paul Rees, Val Millar, Anne E. Carpenter
For phenotypic behavior to be understood in the context of cell lineage and local environment, properties of individual cells must be measured relative to population-wide traits. However, the inability to accurately identify, track and measure thousa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0788f30c79998b913604a64250202eb
Autor:
Andy Brown, Rik Brydson, Paul Rees, M. R. Brown, Huw D. Summers, Mark D. Holton, James A. Tonkin, Nicole Hondow
Publikováno v:
ACS Nano
Assessing dose in nanoparticle-cell interactions is inherently difficult due to a complex multiplicity of possible mechanisms and metrics controlling particle uptake. The fundamental unit of nanoparticle dose is the number of particles internalized p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf28e540d4f9d25a1355be7af8dc58dc
https://doi.org/10.1021/nn4019619
https://doi.org/10.1021/nn4019619
The controlled and sustained delivery of drugs to a specific location within the body is vitally important for effective treatment of chronic diseases such as cancer. One route in achieving this is to develop drug carrying systems from which release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5918928eec09dc5cfb4e923cf7a1f85a
https://cronfa.swan.ac.uk/Record/cronfa20628
https://cronfa.swan.ac.uk/Record/cronfa20628