Zobrazeno 1 - 10
of 108
pro vyhledávání: '"James A. Thliveris"'
Autor:
Sara M. Telles-Langdon, BKin (Hons), MSc, Vibhuti Arya, BSc (Hons), MSc, Paris R. Haasbeek, David Y.C. Cheung, BSc, Cameron R. Eekhoudt, BSc, MSc, Lana Mackic, BSc, Ashley N. Bryson, BSc, MD, Sonu S. Varghese, BSc, MSc, J. Alejandro Austria, James A. Thliveris, PhD, Harold M. Aukema, PhD, Amir Ravandi, MD, PhD, FRCPC, Pawan K. Singal, PhD, DSc, LLD (Hon), Davinder S. Jassal, MD, FACC, FCCS, FRCPC
Publikováno v:
CJC Open, Vol 6, Iss 7, Pp 925-937 (2024)
Background: Although the current combination of surgery, radiation, and chemotherapy is used in the breast-cancer setting, the administration of the anticancer drugs doxorubicin and trastuzumab is associated with an increased risk of developing heart
Externí odkaz:
https://doaj.org/article/7192a5d768c845a6b6b81c6bb6ecc292
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in 25% of cases. We previously demonst
Externí odkaz:
https://doaj.org/article/52ed6a33c85240aabe3ce0ed276692d7
Autor:
Mohammad Norouzi, Vinith Yathindranath, James A. Thliveris, Brian M. Kopec, Teruna J. Siahaan, Donald W. Miller
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of different tumors, its effectiveness in treating glioblastoma multiforme (GBM) is constrained by insufficient penetration across the blood–brain b
Externí odkaz:
https://doaj.org/article/48789dff986642a393532b6e887ac3be
Publikováno v:
Nanomaterials, Vol 10, Iss 3, p 477 (2020)
Salinomycin is an antibiotic introduced recently as a new and effective anticancer drug. In this study, magnetic iron oxide nanoparticles (IONPs) were utilized as a drug carrier for salinomycin for potential use in glioblastoma (GBM) chemotherapy. Th
Externí odkaz:
https://doaj.org/article/863192a84d9a4701b581de3c33457920
Autor:
James A. Thliveris, Donald W. Miller, Marlyn Dian Laksitorini, Wei Xiong, Vinith Yathindranath, Fiona E. Parkinson
Publikováno v:
Journal of Neurochemistry. 157:1118-1137
Chronic exposure to ethanol is associated with enhanced leakiness in the brain microvessel endothelial cells that form the blood-brain barrier (BBB). As previous studies suggested Wnt/β-catenin signaling could improve the BBB phenotype of brain endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8145f6b58c91e6f08d52301a02adbc
https://doi.org/10.1111/jnc.15203
https://doi.org/10.1111/jnc.15203
Autor:
Vernon W. Dolinsky, Simone C. da Silva Rosa, Saeid Ghavami, Christof Rampitsch, Lucas Nguyen, James A. Thliveris, Matthew D. Martens, Donald Chapman, Joseph W. Gordon, Adrian R. West, Stephanie M. Kereliuk, Yan Hai, Jared T. Field, William Diehl-Jones, Michel Aliani
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the mitophagy receptor BNIP3L/Nix is responsive to lipotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c598ae3b4f6203556889028fbb2e0e46
https://doi.org/10.1080/15548627.2020.1821548
https://doi.org/10.1080/15548627.2020.1821548
Autor:
Andrea L. Edel, Grant N. Pierce, Chantal Y. Asselin, Davinder S. Jassal, Saroj Niraula, Antonia Zhu, Amir Ravandi, Cameron R. Eekhoudt, Ishika Mittal, J. Alejandro Austria, Pawan K. Singal, Amy Lam, James A. Thliveris, David Cheung, Andrew Mayba, Harold M. Aukema, Zahra Solati
Publikováno v:
The Journal of Nutrition. 150:2353-2363
BACKGROUND Although the combination of doxorubicin (DOX) and trastuzumab (TRZ) reduces the progression and recurrence of breast cancer, these anticancer drugs are associated with significant cardiotoxic side effects. OBJECTIVE We investigated whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d505f626cc2de0f693fa4c64697b6cd
https://doi.org/10.1093/jn/nxaa144
https://doi.org/10.1093/jn/nxaa144
Autor:
Rimpy Dhingra, Victoria Margulets, James A. Thliveris, Mina Rasouli, Tami A. Martino, Lorrie A. Kirshenbaum, Tarak N. Khatua, Cristine J. Reitz, Illana Posen, Inna Rabinovich-Nikitin
Publikováno v:
Autophagy
Cardiac function is highly reliant on mitochondrial oxidative metabolism and quality control. The circadian Clock gene is critically linked to vital physiological processes including mitochondrial fission, fusion and bioenergetics; however, little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb87172405af69d4cf1baefd0836504
https://europepmc.org/articles/PMC8632283/
https://europepmc.org/articles/PMC8632283/
Autor:
Viktoriya Mozolevska, David Cheung, Andrea L. Edel, Esther Kim, James A. Thliveris, Anna Schwartz, Bella Dingman, Ishika Mittal, Amir Ravandi, Piotr Czaykowski, Bilal Shaikh, Chantal Y. Asselin, Davinder S. Jassal, Vineet Goyal, Pawan K. Singal
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H446-H458
Although anticancer systemic therapy agents clearly lead to improved survival in patients with cancer, these can come at the cost of serious complications including cardiotoxicity. Two types of targeted systemic therapies currently in use for colorec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5eb152f8e558b78c00f37eca665a5f
https://doi.org/10.1152/ajpheart.00344.2018
https://doi.org/10.1152/ajpheart.00344.2018
Autor:
Brian M. Kopec, Teruna J. Siahaan, Donald W. Miller, James A. Thliveris, Mohammad Norouzi, Vinith Yathindranath
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of different tumors, its effectiveness in treating glioblastoma multiforme (GBM) is constrained by insufficient penetration across the blood–brain barrier (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a5b20532efc9af5679352e502660fa
https://doi.org/10.1038/s41598-020-68017-y
https://doi.org/10.1038/s41598-020-68017-y