Výsledky vyhledávání - "James A. Szalony"

Autor: James A. Szalony, Nancy S. Nicholson, Thomas J. Girard, Beatrice B. Taite, Rhonda M Lachance

Publikováno v: Journal of Thrombosis and Thrombolysis. 14:113-121

The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e157b22355e82669e3aed476ca94bb35
https://doi.org/10.1023/a:1023228827733

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SC-54684A: An Orally Active Inhibitor of Platelet Aggregation

Autor: Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony

Publikováno v: Circulation. 91:403-410

Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403

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ChemInform Abstract: Orbofiban: An Orally Active GPIIb/IIIa Platelet Receptor Antagonist

Autor: Norman A. Abood, Anita K. Salyers, Beatrice B. Taite, Susan G. Panzer-Knodle, Osman D. Suleymanov, Nancy S. Nicholson, Leo G. Frederick, Robert J. Anders, James A. Szalony, Jimmy D. Page

Publikováno v: ChemInform. 32

A key role has been established for platelet activation and thrombus formation in the pathogenesis of acute coronary syndromes, and restenosis after percutaneous interventions. Antiplatelet agents that have a wider spectrum of activity than aspirin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::612943204336f54d9eb2fc9fd7c09e63
https://doi.org/10.1002/chin.200127240

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Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model

Autor: James A. Szalony, Wood Rhonda, Nancy S. Nicholson, John J. Parlow, Rhonda M Lachance, Osman D. Suleymanov, South Michael S, Anita K. Salyers

Publikováno v: The Journal of pharmacology and experimental therapeutics. 306(3)

This study was designed to evaluate the antithrombotic efficacy and bleeding propensity of a selective, small-molecule inhibitor of tissue factor/factor VIIa (TF/VIIa) in comparison to small-molecule, selective inhibitors of factor Xa and thrombin in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b13e71ec296c9cb381b7dbd3377a51d
https://pubmed.ncbi.nlm.nih.gov/12829728

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Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment

Autor: Osman D. Suleymanov, John J. Parlow, South Michael S, Nancy S. Nicholson, Wood Rhonda, Anita K. Salyers, James A. Szalony

Publikováno v: Pharmacology. 70(2)

This study in non-human primates was designed to evaluate the bleeding propensity of a selective, small molecule inhibitor of tissue factor (TF)/VIIa in combination with acetylsalicylic acid (ASA) in comparison to the combination of ASA and warfarin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07928abaaa304a962214ffd1b522d33f
https://pubmed.ncbi.nlm.nih.gov/14685013

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Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time

Autor: Michael S. South, John J. Parlow, James A Szalony, Rhonda M. Lachance, Susan G Panzer-Knodle, Jason D. Blom, Rhonda S Wood, Anita K. Salyers, Brenda L. Case, Nancy S. Nicholson, Osman D. Suleymanov

Publikováno v: Thrombosis research. 112(3)

Introduction : Pharmacological treatment of deep vein thrombosis (DVT) in the future may target inhibitors of specific procoagulant proteins. This study used a non-human primate model to test the effect of PHA-798, a specific inhibitor of the tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3bc577e9fa53aae2358f8839f3cea9
https://pubmed.ncbi.nlm.nih.gov/14967414

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Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis

Autor: James A, Szalony, Beatrice B, Taite, Thomas J, Girard, Nancy S, Nicholson, Rhonda M, LaChance

Publikováno v: Journal of thrombosis and thrombolysis. 14(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9cb62dbfdba309a834d45bc70b7c986
https://pubmed.ncbi.nlm.nih.gov/12714830

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Orbofiban: an orally active GPIIb/IIIa platelet receptor antagonist

Autor: Robert J. Anders, Susan G. Panzer-Knodle, Jimmy D. Page, Nancy S. Nicholson, Beatrice B. Taite, Norman A. Abood, Anita K. Salyers, Osman D. Suleymanov, Leo G. Frederick, James A. Szalony

Publikováno v: Medicinal research reviews. 21(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87aae3f2b09cb3b7546fdafb71fc374c
https://pubmed.ncbi.nlm.nih.gov/11301411

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Protective effect of oral xemilofiban in arterial thrombosis in dogs: increased activity in combination with aspirin

Autor: Larry P. Feigen, Leo G. Frederick, James A. Szalony, Lucy W. King, Nancy S. Nicholson, Anita K. Salyers, Osman D. Suleymanov, Beatrice B. Taite

Publikováno v: Circulation. 98(8)

Background —Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in antithrombotic activity. We report on the antithrombotic effect of xemilofiban (SC-54684A), an or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe22c0e819358242abf0fefbc14bf7
https://pubmed.ncbi.nlm.nih.gov/9727553

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Assessment of platelet function assays

Autor: Neal F. Haas, David M. Lansky, Beatrice B. Taite, Nancy S. Nicholson, Anita K. Salyers, Jimmy D. Page, James A. Szalony, Larry P. Feigen, S.G. Panzer-Knodle

Publikováno v: American heart journal. 135(5 Pt 2)

Optical aggregometry, traditionally used to assess platelet function, is highly dependent on sample preparation and technical procedure; as a result, data from various laboratories can be quite variable. In a study designed to assess the sources of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d211dcd17134dbeeb8a43003dfd35
https://pubmed.ncbi.nlm.nih.gov/9588396

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