Zobrazeno 1 - 10
of 67
pro vyhledávání: '"James A. Stover"'
Publikováno v:
Medicine. 101(37)
This study sought to characterize the utility of a gene methylation-based biomarker test that has been validated to predict progression towards esophageal adenocarcinoma. Barrett esophagus (BE) is a precursor condition for esophageal adenocarcinoma (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b77be4900a35dcb0a15270044b33cf
https://pubmed.ncbi.nlm.nih.gov/36123898
https://pubmed.ncbi.nlm.nih.gov/36123898
Publikováno v:
Journal of the American Chemical Society. 129:2074-2081
The electrochemical and chemical oxidation of a series of C8-arylamine adducts of 2'-deoxyguanosine has been examined. The oxidations were found to be reversible by cyclic and square-wave voltammetry in both aqueous buffer and aprotic organic solvent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83c324993d9b3234ba00c2302a541b5
https://doi.org/10.1021/ja066404u
https://doi.org/10.1021/ja066404u
Publikováno v:
Chemical Research in Toxicology. 19:1506-1517
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is found in cooked meats and forms DNA adducts at the C8- and N2-positions of dGuo after appropriate activation. IQ is a potent inducer of frameshift mutations in bacteria and is carcinogenic in laboratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f158d489e5e8e0f7ab71f65ff3e3563
https://doi.org/10.1021/tx0601455
https://doi.org/10.1021/tx0601455
Autor:
Carmelo J. Rizzo, Jeong-Yun Choi, Goutam Chowdhury, F. Peter Guengerich, Karen C. Angel, James S. Stover
Publikováno v:
Journal of Biological Chemistry. 281:25297-25306
Heterocyclic arylamines are highly mutagenic and cause tumors in animal models. The mutagenicity is attributed to the C8- and N2-G adducts, the latter of which accumulates due to slower repair. The C8- and N 2-G adducts derived from 2-amino-3-methyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88bb146f1814f2f6e582397beb82f9f
https://doi.org/10.1074/jbc.m605699200
https://doi.org/10.1074/jbc.m605699200
Publikováno v:
Journal of the American Chemical Society. 128:10085-10095
The solution structure of the oligodeoxynucleotide 5'-d(CTCGGCXCCATC)-3'.5'-d(GATGGCGCCGAG)-3' containing the heterocyclic amine 8-[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-2'-deoxyguanosine adduct (IQ) at the third guanine in the NarI restric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd1de3a672f9a54ad0c938b12a3cb47
https://doi.org/10.1021/ja062004v
https://doi.org/10.1021/ja062004v
Autor:
Carmelo J. Rizzo, James S. Stover
Publikováno v:
Organic Letters. 6:4985-4988
After bioactivation, the potent dietary mutagen 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) reacts with DNA to give two regioisomeric adducts of deoxyguanosine. The synthesis of the minor N2-adduct has been achieved utilizing the Buchwald−Hartwig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2fb937d03ee45c14ceaf6f37ab8a8b0
https://doi.org/10.1021/ol047851m
https://doi.org/10.1021/ol047851m