Zobrazeno 1 - 10
of 53
pro vyhledávání: '"James A. Pippin"'
Autor:
Matthew C. Pahl, Lin Liu, James A. Pippin, Yadav Wagley, Keith Boehm, Kurt D. Hankenson, Andrew D. Wells, Wenli Yang, Struan F.A. Grant
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105038- (2024)
Summary: Background: Carpal tunnel syndrome (CTS) is a common disorder caused by compression of the median nerve in the wrist, resulting in pain and numbness throughout the hand and forearm. While multiple behavioural and physiological factors influe
Externí odkaz:
https://doaj.org/article/936e1d8008fc4156b7c5db74b867d0b6
Autor:
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 830-842 (2023)
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium
Externí odkaz:
https://doaj.org/article/3b5bbb61491c43eda5c548a0bbb7c298
Autor:
Matthew C. Pahl, Carole Le Coz, Chun Su, Prabhat Sharma, Rajan M. Thomas, James A. Pippin, Emylette Cruz Cabrera, Matthew E. Johnson, Michelle E. Leonard, Sumei Lu, Alessandra Chesi, Kathleen E. Sullivan, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background SARS-CoV-2 infection results in a broad spectrum of COVID-19 disease, from mild or no symptoms to hospitalization and death. COVID-19 disease severity has been associated with some pre-existing conditions and the magnitude of the
Externí odkaz:
https://doaj.org/article/8df9b6167b7e4c4c861156596c1735c6
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Autor:
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, Matthew C. Pahl, Shana E. McCormack, Alessandra Chesi, Jonathan A. Mitchell, Joseph M. Kindler, Denis Baird, April Hartley, Laura Howe, Heidi J. Kalkwarf, Joan M. Lappe, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Hakon Hakonarson, Vicente Gilsanz, John A. Shepherd, Sharon E. Oberfield, Casey S. Greene, Andrea Kelly, Deborah A. Lawlor, Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by m
Externí odkaz:
https://doaj.org/article/165481b925744dddb170926499acd9cc
Autor:
Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Externí odkaz:
https://doaj.org/article/5ea732da22e64125aa7a08b992a12fda
Autor:
Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in
Externí odkaz:
https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci
Autor:
Reza K Hammond, Matthew C Pahl, Chun Su, Diana L Cousminer, Michelle E Leonard, Sumei Lu, Claudia A Doege, Yadav Wagley, Kenyaita M Hodge, Chiara Lasconi, Matthew E Johnson, James A Pippin, Kurt D Hankenson, Rudolph L Leibel, Alessandra Chesi, Andrew D Wells, Struan FA Grant
Publikováno v:
eLife, Vol 10 (2021)
To uncover novel significant association signals (p
Externí odkaz:
https://doaj.org/article/b274c0761bcc4c1a8945975510fddef6
Autor:
Andrei Thomas-Tikhonenko, Struan F.A. Grant, James A. Pippin, Manuel Torres-Diz, Katharina Hayer, Priyanka Sehgal, Claudia B. Lanauze
About 10% to 30% of patients with colorectal cancer harbor either loss of or missense mutations in SMAD4, a critical component of the TGFβ signaling pathway. The pathophysiologic function of missense mutations in Smad4 is not fully understood. They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98265ca73ce1e4a48df2705e6b56cac5
https://doi.org/10.1158/1541-7786.c.6545193.v1
https://doi.org/10.1158/1541-7786.c.6545193.v1
Autor:
Andrei Thomas-Tikhonenko, Struan F.A. Grant, James A. Pippin, Manuel Torres-Diz, Katharina Hayer, Priyanka Sehgal, Claudia B. Lanauze
S1. Wnt signaling in CRC cell lines with Smad4 R361 mutations. S2. Wnt signaling in CRC cell lines with Smad4 R361 mutations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345ca818af4f5cd876c0091d8c8514b3
https://doi.org/10.1158/1541-7786.22526730.v1
https://doi.org/10.1158/1541-7786.22526730.v1