Zobrazeno 1 - 10 of 153 pro vyhledávání: '"James A. Mullin"'
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Akademický článek
Growth factors and growth factor gene therapies for treating chronic wounds
Autor: James A. Mullin, Erfan Rahmani, Kristi L. Kiick, Millicent O. Sullivan
Publikováno v: Bioengineering & Translational Medicine, Vol 9, Iss 3, Pp n/a-n/a (2024)
Abstract Chronic wounds are an unmet clinical need affecting millions of patients globally, and current standards of care fail to consistently promote complete wound closure and prevent recurrence. Disruptions in growth factor signaling, a hallmark o
Externí odkaz: https://doaj.org/article/9018350fe54c4f1699075814ff164023
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6
Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study
Autor: James M. Mullin, Viera Lukacova, Maxime Le Merdy
Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics
A physiologically based model describing the dissolution, diffusion, and transfer of drug from the intra-articular (IA) space to the plasma, was developed for GastroPlus® v9.8. The model is subdivided into compartments representing the synovial flui
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c729c5b6913317fd70841476d14d277b
https://doi.org/10.1007/s10928-021-09781-w
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8
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies
Autor: Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen
Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bca05a74d852f38ad03c52e9e4fba40
https://doi.org/10.1016/j.ejpb.2020.08.006
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10
Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy
Autor: Katherine M. DiGuilio, Elizabeth Rybakovsky, Reza Abdavies, Romy Chamoun, Colleen A. Flounders, Ariel Shepley-McTaggart, Ronald N. Harty, James M. Mullin
Publikováno v: International journal of molecular sciences. 23(6)
The published literature makes a very strong case that a wide range of disease morbidity associates with and may in part be due to epithelial barrier leak. An equally large body of published literature substantiates that a diverse group of micronutri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cba0e876394d6d4eb2e4cb3e3639ed1
https://pubmed.ncbi.nlm.nih.gov/35328419
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