Zobrazeno 1 - 10
of 115
pro vyhledávání: '"James A. Monn"'
Autor:
Mark J. Benvenga, Stephen F. Chaney, Melvyn Baez, Thomas C. Britton, William J. Hornback, James A. Monn, Gerard J. Marek
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive
Externí odkaz:
https://doaj.org/article/9f965940a60d4dd5ac6205b068ebae96
Autor:
Michihiro Tateyama, Shigetada Nakanishi, James A. Monn, Ryuichi Shigemoto, Robert M. Duvoisin, Hans Bräuner-Osborne, Colleen M. Niswender, P. Jeffrey Conn, Francine Acher, Darryle D. Schoepp, Yoshihiro Kubo, Philippe Rondard, David R. Hampson, Cyril Goudet, Peter J. Flor, Karen J. Gregory, Michael P. Johnson, Francesco Ferraguti, Jean-Philippe Pin, Ferdinando Nicoletti, Giuseppe Battaglia
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The ionotropic glutamate receptors comprise members of the NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) and kainate receptor classes, named originally according to their preferred, synthetic, agonist [35,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c92b25b2214a94d5279869aa9c4ef18
https://doi.org/10.2218/gtopdb/f40/2021.3
https://doi.org/10.2218/gtopdb/f40/2021.3
Autor:
Livia Leoni, Giuseppe Battaglia, Rosamaria Orlando, James A. Monn, Giordano Rampioni, M Alborghetti, Roxana Paula Ginerete, Francesco Fornai, G D'Errico, Valeria Bruno, F. Nicoletti, Paolo Visca, L. Di Menna, Carla L. Busceti
Interkingdom communication between bacteria and host organisms is one of the most interesting research topics in biology. Quorum sensing molecules produced by Gram-negative bacteria, such as acylated homoserine lactones and quinolones, have been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ead99338605a8b46ac2affe460a063
https://hdl.handle.net/11573/1557805
https://hdl.handle.net/11573/1557805
Autor:
Giovanna D'Errico, Tiziana Imbriglio, Francesco Fornai, Anna Pittaluga, Giuseppe Battaglia, Luisa Di Menna, Paola Di Pietro, Valeria Bruno, Carla L. Busceti, Ferdinando Nicoletti, Roxana Paula Ginerete, Francesca Cisani, James A. Monn
Group II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors) shape mechanisms of methamphetamine addiction, but the individual role played by the two subtypes is unclear. We measured methamphetamine-induced conditioned place preference (CPP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9feeab431ba315ec7f84d0c17aad2a
http://hdl.handle.net/11568/1104094
http://hdl.handle.net/11568/1104094
Autor:
Joseph D. Ho, Michelle C. Vargas, Jing Wang, Junliang Hao, Shane Atwell, James A. Monn, Sheela Ashok, Mark G. Bures, Qi Chen, Jeffery M. Schkeryantz
Publikováno v:
Journal of Medicinal Chemistry. 61:10040-10052
( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu8 receptor, but the structural basis for its high selectivity is not well understood. We have solved a cocryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33be9a640f18a032be5e1bd51cd0d5b7
https://doi.org/10.1021/acs.jmedchem.8b01120
https://doi.org/10.1021/acs.jmedchem.8b01120
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481
Autor:
David O. Calligaro, Paul L. Ornstein, Renhua Li, Phillips K, David L. McKinzie, Allen D, Jun-Xu Li, James A. Monn, Bryan G. Johnson, Stephon C. Smith, Jeffrey M. Witkin, Charles H. Mitch, Beverly A. Heinz, Steven Swanson, Gilmour G, Xushan Wang
Publikováno v:
Pharmacology Biochemistry and Behavior. 155:43-55
The novel mGlu2/3 receptor antagonist, LY3020371, has been shown to produce antidepressant-like effects comparable to that of the clinically-effective antidepressant ketamine. In the present study, we investigated whether LY3020371 would be predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5d9f0613b0e20654a6756ac6802a7
https://doi.org/10.1016/j.pbb.2017.03.001
https://doi.org/10.1016/j.pbb.2017.03.001
Autor:
Dominic L. Li, Mark A. Muhlhauser, Denise Morrow, Lijuan Yang, James A. Monn, Michael P. Johnson, Kelly L. Knopp, Rosa Maria A. Simmons, Steven Swanson, Beth M. Forster, Eric S. Nisenbaum, Jeffrey D. Kennedy
Publikováno v:
British Journal of Pharmacology. 174:822-835
Background and Purpose A body of evidence suggests activation of metabotropic glutamate 2/3 (mGlu2/3) receptors would be an effective analgesic in chronic pain conditions. Thus, the analgesic properties of a novel mGlu2/3 receptor agonist prodrug wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::695acf8d9210d1c7b441e8cf3e534bb9
https://doi.org/10.1111/bph.13740
https://doi.org/10.1111/bph.13740
Autor:
Chuanxi Xiang, Steven Swanson, Joan H. Carter, Paul L. Ornstein, Lisa M. Broad, Charles H. Mitch, Xu Shan Wang, Wesley H. Anderson, Helen E. Sanger, Renhua Li, Jeffrey M. Witkin, Stephon C. Smith, Stephen M. Fitzjohn, Francesca Pasqui, Xia Li, Jodi L. Smith, James A. Monn, Beverly A. Heinz, John T. Catlow
Publikováno v:
Neuropharmacology. 115:100-114
Metabotropic glutamate 2/3 (mGlu2/3) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic, postsynaptic and glial mechanisms. As part of our ongoing efforts to identify novel ligands for thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52de977d52418e1e92a87b1acf0f81d6
https://doi.org/10.1016/j.neuropharm.2015.12.021
https://doi.org/10.1016/j.neuropharm.2015.12.021
Autor:
Christian C. Felder, Ed Siuda, Chuanxi Xiang, Hongling Xiao, James A. Monn, Lourdes Prieto, Anne T. Quets, David L. McKinzie, Beverly A. Heinz, Marla L. Watt, Douglas A. Schober, Yuan Tu, Eric S. Nisenbaum
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:190-197
LY2812223 [(1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid] was identified via structure-activity studies arising from the potent metabotropic glutamate mGlu2/3 receptor agonist LY354740 [(+)-2-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf1c55697faf52f729e7376c25a77a1
https://doi.org/10.1124/jpet.116.237859
https://doi.org/10.1124/jpet.116.237859