Zobrazeno 1 - 10
of 951
pro vyhledávání: '"James A. MacDonald"'
Autor:
Sina A. Gharib, Rachna Vemireddy, Joseph J. Castillo, Brendy S. Fountaine, Theo K. Bammler, James W. MacDonald, Rebecca L. Hull-Meichle, Sakeneh Zraika
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Insulin secretion is impaired in individuals with cystic fibrosis (CF), contributing to high rates of CF-related diabetes (CFRD) and substantially increasing disease burden. To develop improved therapies for CFRD, better knowledge of pancrea
Externí odkaz:
https://doaj.org/article/02eecb3558cb4daeb1a5360a32a28b02
Autor:
Brennan H. Baker, Sheela Sathyanarayana, Adam A. Szpiro, James W. MacDonald, Alison G. Paquette
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Missing covariate data is a common problem that has not been addressed in observational studies of gene expression. Here, we present a multiple imputation method that accommodates high dimensional gene expression data by incorporating princi
Externí odkaz:
https://doaj.org/article/cfe23f7d729542beb02b0d1b2ce36059
Autor:
Kevin A. Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W. MacDonald, Theo K. Bammler, Justina Calamia, Kenneth E. Thummel, Catherine K. Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J. Kelly
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of
Externí odkaz:
https://doaj.org/article/080dc77d0559426aa337057d6101081e
Publikováno v:
Glomerular Diseases, Vol 4, Iss 1, Pp 49-63 (2024)
Background: The first spatially resolved transcriptomics platforms, GeoMx (Nanostring) and Visium (10x Genomics) were launched in 2019 and were recognized as the method of the year by Nature Methods in 2020. The subsequent refinement and expansion of
Externí odkaz:
https://doaj.org/article/74aa88bd3b7b4200ac6804f26a76fdbf
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
Andrea H. Johnson, MSN, CRNP, Jane C. Brennan, MS, Paul J. King, MD, Justin J. Turcotte, PhD, MBA, James H. MacDonald, MD
Publikováno v:
Arthroplasty Today, Vol 27, Iss , Pp 101359- (2024)
Background: As life expectancy improves for patients with dementia, the demand for mobility-improving surgeries such as total joint arthroplasty (TJA) will increase. There is little research on patients with dementia undergoing TJA, although dementia
Externí odkaz:
https://doaj.org/article/3d92b6749a8b416cba2b5c089bbf508b
Autor:
Laura A. Stock, Andrea H. Johnson, Jane C. Brennan, Justin J. Turcotte, Paul J. King, James H. MacDonald
Publikováno v:
Arthroplasty, Vol 5, Iss 1, Pp 1-9 (2023)
Abstract Background Various episode-of-care bundled payment models for patients undergoing total joint arthroplasty have been implemented. However, participation in bundled payment programs has dropped given the challenges of meeting continually lowe
Externí odkaz:
https://doaj.org/article/77a23708b3274aceb97a4d3c5f656a0e
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Synthetic networks require complex intertwined genetic regulation often relying on transcriptional activation or repression of target genes. CRISPRi-based transcription factors facilitate the programmable modulation of endogenous or syntheti
Externí odkaz:
https://doaj.org/article/910724e32624468682f45dfa01157ca8
Autor:
Laura A. Stock, Kevin Dennis, James H. MacDonald, Andrew J. Goins, Justin J. Turcotte, Paul J. King
Publikováno v:
Arthroplasty, Vol 4, Iss 1, Pp 1-8 (2022)
Abstract Background Spinal anesthesia (SA) has been previously associated with improved outcomes after total joint arthroplasty (TJA). The purpose of this study was to compare outcomes between various local anesthetics. Methods This was a retrospecti
Externí odkaz:
https://doaj.org/article/3dd9b3aff08440cda888f2b6b8afc4fa
Autor:
Justin J. Turcotte, McKayla E. Kelly, Alyssa B. Fenn, Jennifer J. Grover, Christina A. Wu, James H. MacDonald
Publikováno v:
Arthroplasty, Vol 4, Iss 1, Pp 1-9 (2022)
Abstract Background The purpose of this study was to evaluate the relationship between lower extremity functional scale (LEFS) scores with postoperative functional outcomes for total joint arthroplasty (TJA) patients and to investigate the utility of
Externí odkaz:
https://doaj.org/article/aec6615c43b441d0997dd03bae21466a