Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James A. Lausier"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L185-L192
We hypothesized that foreign bodies in airways cause inflammation leading to goblet cell metaplasia. Instilled agarose plugs lodged in the bronchi of pathogen-free rats caused a time-dependent increase in Alcian blue-periodic acid-Schiff staining tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e4e4a15a4e648168f70ccf7cdab55c
https://doi.org/10.1152/ajplung.2000.278.1.l185
https://doi.org/10.1152/ajplung.2000.278.1.l185
Publikováno v:
The Journal of Immunology. 162:6233-6237
Goblet cell metaplasia and mucus hypersecretion are important features in the pathogenesis of asthma. The cytokine IL-4 has been shown to play a role in animal models of asthma, where it induces Th2 lymphocyte differentiation and B lymphocyte IgE cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7323496792beebf707fdcf2e69ffdacb
https://doi.org/10.4049/jimmunol.162.10.6233
https://doi.org/10.4049/jimmunol.162.10.6233
Autor:
Kathleen M. Grattan, Iris F. Ueki, Kiyoshi Takeyama, Heung-Man Lee, Karim Dabbagh, Carlos Agustí, James A. Lausier, Jay A. Nadel
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3081-3086
Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying mechanisms are unknown, and no effective therapy exists. Here we show that stimulation of epidermal growth factor receptors (EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e640be5b440263953fba5466444bea9
https://doi.org/10.1073/pnas.96.6.3081
https://doi.org/10.1073/pnas.96.6.3081
Autor:
Kiyoshi Takeyama, Ya-Ping Lou, Iris F. Ueki, Lars-Olaf Cardell, James A. Lausier, Jay A. Nadel
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 11:309-315
Recent reports indicate the presence of two carbon monoxide (CO)-inducing enzymes, heme oxygenase (HO)-1 and -2 in airway smooth muscle. Generally HO-2 is considered to be a constitutive enzyme associated with various neuronal structures, whereas HO-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003ab8830c8aab53199616cc5788bc0e
https://doi.org/10.1006/pupt.1998.0152
https://doi.org/10.1006/pupt.1998.0152
Autor:
Iris F. Ueki, Kiyoshi Takeyama, Ya-Ping Lou, Kathleen M. Grattan, Carlos Agustí, James A. Lausier, Jay A. Nadel
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 157:1927-1934
In patients dying from asthma, extensive mucous plugging occurs in the airways, associated with goblet cell hyperplasia. In this study, we examined the hypothesis that platelet-activating factor (PAF) induces goblet cell hyperplasia and mucin gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe0146c9c8ea80cc7be0fb40bd010ed
https://doi.org/10.1164/ajrccm.157.6.9709113
https://doi.org/10.1164/ajrccm.157.6.9709113
Autor:
Iris F. Ueki, Austin F. Dohrman, Jeffrey A. Golden, James A. Lausier, Jay A. Nadel, Brendan Chan, Kathleen M. Grattan, Masato Hara, Pierre P. Massion, Hiromasa Inoue
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 11:651-663
Neutrophils may play important roles in chronic airway diseases. Pseudomonas is a common pathogen in some chronic airway diseases, and expression of the neutrophil chemoattractant interleukin-8 (IL-8) is induced by Pseudomonas in various cells in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3449bbb65ef640d1ac8a3c4a863735a1
https://doi.org/10.1165/ajrcmb.11.6.7946394
https://doi.org/10.1165/ajrcmb.11.6.7946394
Autor:
Iris F. Ueki, James A. Lausier, Jay A. Nadel, Carlos Agustí, Lars-Olaf Cardell, Kiyoshi Takeyama
Publikováno v:
The American journal of physiology. 275(2)
We examined the effect of the neutrophil chemoattractants interleukin (IL)-8 and N-formyl-methionyl-leucyl-phenylalanine on goblet cell (GC) degranulation in guinea pigs. Chemoattractants caused time-dependent neutrophil recruitment and GC degranulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38177f8d2934af533c6235e1c8ff1673
https://pubmed.ncbi.nlm.nih.gov/9700090
https://pubmed.ncbi.nlm.nih.gov/9700090
Autor:
Demetrios Papahadjopoulos, Shigemi Yoshihara, Keelung Hong, James A. Lausier, Jay A. Nadel, Pierangelo Geppetti, Weiming Zhang, Joseph Rosenecker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(14)
We have used a pharmacologic mediator to open intercellular connections in selected vessels to allow liposomes to escape from the blood stream and to extravasate into tissues that have appropriate receptors. We have examined the effects of substance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93d8740998a02bce68bf33d3f07b76
https://pubmed.ncbi.nlm.nih.gov/8692975
https://pubmed.ncbi.nlm.nih.gov/8692975
Autor:
Sandra Huling, Kenneth R. Feingold, Judy K. Shigenaga, James A. Lausier, Arthur H. Moser, Janet L. Funk, Carl Grunfeld, Gordon J Strewler, Robert A. Nissenson
Publikováno v:
Endocrinology. 136(8)
PTH-related protein (PTHrP), the peptide that is responsible for most cases of hypercalcemia of malignancy, is also produced under normal circumstances by a variety of tissues. Its role and regulation at these sites are not well understood. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adef170b686f5cfb81219f05bb29a8c6
https://pubmed.ncbi.nlm.nih.gov/7628377
https://pubmed.ncbi.nlm.nih.gov/7628377