Zobrazeno 1 - 10
of 133
pro vyhledávání: '"James A. Imlay"'
Autor:
Stefanie S. Eben, James A. Imlay
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be. It has often been suggested tha
Externí odkaz:
https://doaj.org/article/fb10237a99c94e379565e8047e09bdde
Autor:
Sanjay Kumar Rohaun, James A. Imlay
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102495- (2022)
Radical S-adenosylmethionine enzymes (RSEs) drive diverse biological processes by catalyzing chemically difficult reactions. Each of these enzymes uses a solvent-exposed [4Fe–4S] cluster to coordinate and cleave its SAM co-reactant. This cluster is
Externí odkaz:
https://doaj.org/article/05f25b70174d4c669f3ec6bdfcfa2ead
Autor:
Yidan Zhou, James A. Imlay
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT CyuA of Escherichia coli is an inducible desulfidase that degrades cysteine to pyruvate, ammonium, and hydrogen sulfide. Workers have conjectured that its role may be to defend bacteria against the toxic effects of cysteine. However, cyuA si
Externí odkaz:
https://doaj.org/article/c8ec28a910cf493e80099a88976ace37
Autor:
Ananya Sen, James A. Imlay
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes. The reactive oxygen species (ROS) superoxide and hydrogen peroxide react rapidly with iron, and inside cells they can generate both enzyme and DNA damage. RO
Externí odkaz:
https://doaj.org/article/d67230b3f7ee46bb9d95582ffbd8bfe2
Autor:
Yidan Zhou, James A. Imlay
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT The most direct route by which microbes might assimilate sulfur would be by importing cysteine. However, alone among the amino acids, cysteine does not have well-characterized importers. We determined that Escherichia coli can rapidly import
Externí odkaz:
https://doaj.org/article/665f49a2ade74b7c867f40cac42a35fb
Autor:
Zheng Lu, James A. Imlay
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Organisms have evolved two different classes of the ubiquitous enzyme fumarase: the [4Fe–4S] cluster-containing class I enzymes are oxidant-sensitive, whereas the class II enzymes are iron-free and therefore oxidant-resistant. When hydrogen peroxid
Externí odkaz:
https://doaj.org/article/5800af65b9af4a468d69b8fd20611d86
Autor:
Zheng Lu, James A. Imlay
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The impact of oxidative stress upon organismal fitness is most apparent in the phenomenon of obligate anaerobiosis. The root cause may be multifaceted, but the intracellular generation of reactive oxygen species (ROS) likely plays a key role
Externí odkaz:
https://doaj.org/article/40dcb61758684409ad0ef3cd586ed274
Autor:
Stefanie S. Eben, James A. Imlay
Publikováno v:
Molecular Microbiology. 119:423-438
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c401992f635eb0dfed25d50d2d32de6e
https://doi.org/10.1111/mmi.15032
https://doi.org/10.1111/mmi.15032
Autor:
Gilberto C. Padron, Alexander M. Shuppara, Anuradha Sharma, Matthias D. Koch, Jessica-Jae S. Palalay, Jana N. Radin, Thomas E. Kehl-Fie, James A. Imlay, Joseph E. Sanfilippo
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. Using microfluidics and single-cell imaging, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2957aa9c19435ee00b80a14a21c38aa
https://doi.org/10.1073/pnas.2216774120
https://doi.org/10.1073/pnas.2216774120
Autor:
Gilberto C. Padron, Alexander M. Shuppara, Anuradha Sharma, Matthias D. Koch, Jessica-Jae S. Palalay, Jana N. Radin, Thomas E. Kehl-Fie, James A. Imlay, Joseph E. Sanfilippo
Cells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. Using microfluidics and single-cell imaging, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f8e6717c3c3808e22544fbe36cbacf
https://doi.org/10.1101/2022.09.07.506966
https://doi.org/10.1101/2022.09.07.506966
