Zobrazeno 1 - 10
of 801
pro vyhledávání: '"James A. Hurley"'
Autor:
James C. Hurley
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Spillover of effect, whether positive or negative, from intervention to control group patients invalidates the Stable Unit Treatment Variable Assumption (SUTVA). SUTVA is critical to valid causal inference from randomized concurre
Externí odkaz:
https://doaj.org/article/d21327efefc340f9b8708975bf0fa3db
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/22e9cdbc32884dff8e2af01509511c7d
Autor:
James C. Hurley
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Background Has either the underlying risk or the mortality incidence among ICU patients receiving mechanical ventilation (MV) in the literature changed in recent decades? Interpreting ICU mortality trends requires an adjusted analysis accoun
Externí odkaz:
https://doaj.org/article/305142d886dd414a8b1108028494c783
Autor:
James C. Hurley
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Infection prevention interventions within the intensive care unit (ICU) setting, whether studied within quality improvement projects or cluster randomized trials (CRT), are seen as low risk and grounded in an ethical imperative. S
Externí odkaz:
https://doaj.org/article/751ccb1b9a29417a919db56e0054ab00
Autor:
Varun Kamat, Matthew K. Grumbine, Khang Bao, Kedar Mokate, Gamal Khalil, Daniel Cook, Brandon Clearwater, Richard Hirst, Jarrod Harman, Myriam Boeck, Zhongjie Fu, Lois E.H. Smith, Moloy Goswami, Thomas J. Wubben, Emily M. Walker, Jie Zhu, Scott A. Soleimanpour, Jarrad M. Scarlett, Brian M. Robbings, Daniel Hass, James B. Hurley, Ian R. Sweet
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100642- (2023)
Summary: To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess tissue metabolism and function with simple and rapid systems, we improved on the in
Externí odkaz:
https://doaj.org/article/3224701920bf49ea8c3bff2c8370db61
Autor:
James C. Hurley
Publikováno v:
Emerging Themes in Epidemiology, Vol 19, Iss 1, Pp 1-16 (2022)
Keypoints GSEM modelling of published ICU infection prevention data from > 250 studies enables a test of and provides support to the interaction between Candida and Gram-positive bacteria. The various ICU infection prevention interventions may each b
Externí odkaz:
https://doaj.org/article/35c6c7b8be384db0a92e47f5738cc05a
Autor:
James C. Hurley
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Purpose Animal models implicate candida colonization facilitating invasive bacterial infections. The clinical relevance of this microbial interaction remains undefined and difficult to study directly. Observations from studies of anti-septic
Externí odkaz:
https://doaj.org/article/1bb4575545d140329f4e5a64a9908005
Autor:
Monica Sanchez-Contreras, Mariya T Sweetwyne, Kristine A Tsantilas, Jeremy A Whitson, Matthew D Campbell, Brenden F Kohrn, Hyeon Jeong Kim, Michael J Hipp, Jeanne Fredrickson, Megan M Nguyen, James B Hurley, David J Marcinek, Peter S Rabinovitch, Scott R Kennedy
Publikováno v:
eLife, Vol 12 (2023)
Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs during aging. A thorough characterization of age-associated mtDNA somatic mutatio
Externí odkaz:
https://doaj.org/article/760dc4a6fddb4876a45723742a0cefcc
Autor:
James C. Hurley
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-10 (2021)
Abstract Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral antibiotic prophylaxis (PPAP), appear highly effective for preventing ICU-acquired infections but
Externí odkaz:
https://doaj.org/article/e6fd091a0afc4476aa85a7fd2daccde6
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
C9orf72:SMCR8:WDR41 complex has been reported to have GAP activity for both ARF family proteins and the RAB proteins RAB8A and RAB11A. Here the authors provide structural and biochemical evidence for a specific function of the C9orf72 complex as an A
Externí odkaz:
https://doaj.org/article/68ecccfd058a41458fb45ddd911e60ed