Zobrazeno 1 - 10
of 144
pro vyhledávání: '"James A. Hendrix"'
Autor:
Lauren T. Ptomey, Nicolas M. Oreskovic, James A. Hendrix, Dominica Nichols, Stamatis Agiovlasitis
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2023)
Youth with Down syndrome (DS) have a higher prevalence of overweight and obesity compared to the general youth population. Due to physiological and cognitive differences observed in youth with DS, weight management recommendations developed for the g
Externí odkaz:
https://doaj.org/article/de6e31112b74473ab162721a8669e2fa
Autor:
Kari Knox, Justin Stanley, James A. Hendrix, Hampus Hillerstrom, Taylor Dunn, Jillian Achenbach, Brian A. Chicoine, Florence Lai, Ira Lott, Sanja Stanojevic, Susan E. Howlett, Kenneth Rockwood
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background As life expectancy of people with Down syndrome (DS) increases, so does the risk of Alzheimer’s disease (AD). Identifying symptoms and tracking disease progression is especially challenging whenever levels of function vary befor
Externí odkaz:
https://doaj.org/article/a64e8a0910b64b74b56d860f0cb9fe95
Autor:
Stephen P. Salloway, Jeff Sevingy, Kumar Budur, Jan Torleif Pederson, Ronald B. DeMattos, Philipp Von Rosenstiel, Antonio Paez, Rebecca Evans, Christopher J. Weber, James A. Hendrix, Susan Worley, Lisa J. Bain, Maria C. Carrillo
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple pathologies and pathways of the disease. As such, it has been proposed that AD and its various stages might be most effectively treated with a combin
Externí odkaz:
https://doaj.org/article/28b75d0afd1f436897e12b900a8ab760
Autor:
James A. Hendrix, David C. Airey, Angela Britton, Anna D. Burke, George T. Capone, Ronelyn Chavez, Jacqueline Chen, Brian Chicoine, Alberto C. S. Costa, Jeffrey L. Dage, Eric Doran, Anna Esbensen, Casey L. Evans, Kelley M. Faber, Tatiana M. Foroud, Sarah Hart, Kelsey Haugen, Elizabeth Head, Suzanne Hendrix, Hampus Hillerstrom, Priya S. Kishnani, Kavita Krell, Duvia Lara Ledesma, Florence Lai, Ira Lott, Cesar Ochoa-Lubinoff, Jennifer Mason, Jessie Nicodemus-Johnson, Nicholas Kyle Proctor, Margaret B. Pulsifer, Carolyn Revta, H. Diana Rosas, Tracie C. Rosser, Stephanie Santoro, Kim Schafer, Thomas Scheidemantel, Frederick Schmitt, Brian G. Skotko, Melissa R. Stasko, Amy Talboy, Amy Torres, Kristi Wilmes, Jason Woodward, Jennifer A. Zimmer, Howard H. Feldman, William Mobley
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 9, p 1907 (2021)
With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer’s disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recr
Externí odkaz:
https://doaj.org/article/b0ea0b58afcb45159ce12d7c51681166
Autor:
Nicole T. Baumer, Mara L. Becker, George T. Capone, Kathleen Egan, Juan Fortea, Benjamin L. Handen, Elizabeth Head, James E. Hendrix, Ruth Y. Litovsky, Andre Strydom, Ignacio E. Tapia, Michael S. Rafii
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-9 (2022)
Abstract The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individu
Externí odkaz:
https://doaj.org/article/5a1db19275d74e129d5e2fe30faf7670
Autor:
James A. Hendrixson, Alicen James, Nisreen S. Akel, Dominique J. Laster, Julie A. Crawford, Stuart B. Berryhill, Melda Onal
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 3, Pp 73-84 (2024)
Abstract Chaperone‐mediated autophagy (CMA) is a lysosome‐dependent degradation pathway that eliminates proteins that are damaged, partially unfolded, or targeted for selective proteome remodeling. CMA contributes to several cellular processes, i
Externí odkaz:
https://doaj.org/article/04666c39eed746e8abebce47d4e95d82
Publikováno v:
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 14
The Neuroatypical Conditions Expert Consultative Panel composed of numerous clinical and academic experts was convened to examine barriers to the examination of cognitive impairment in adults with a variety of neuroatypical conditions. Neuroatypical
Autor:
Nicole T. Baumer, Mara L. Becker, George T. Capone, Kathleen Egan, Juan Fortea, Benjamin L. Handen, Elizabeth Head, James E. Hendrix, Ruth Y. Litovsky, Andre Strydom, Ignacio E. Tapia, Michael S. Rafii
Publikováno v:
Journal of neurodevelopmental disorders. 14(1)
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with
Autor:
Dominique J. Laster, Nisreen S. Akel, James A. Hendrixson, Alicen James, Julie A. Crawford, Qiang Fu, Stuart B. Berryhill, Jeff D. Thostenson, Intawat Nookaew, Charles A. O’Brien, Melda Onal
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107428- (2023)
Summary: Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF) studies. A major limitation of this system is recombination in unwanted cell types. CRISPR interference (CRISPRi) has been used effectively for globa
Externí odkaz:
https://doaj.org/article/5c1cae257c474ed682b9ce39c9462ea4
Autor:
David Stefany, Pascal George, Philippe Pichat, Hall Daniel A, Raisa Nagorny, James A. Hendrix, Nicolas Moindrot, Hurst William J, Czechtizky Werngard, Zhongli Gao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6269-6273
Lead optimization guided by histamine H3 receptor (H3R) affinity and calculated physico-chemical properties enabled simultaneous improvement in potency and PK properties leading to the identification of a potent, selective, devoid of hERG issues, ora