Zobrazeno 1 - 10
of 129
pro vyhledávání: '"James A. Ferrendelli"'
Publikováno v:
Journal of Neurochemistry. 26:741-748
—Depolarizing concentrations of K+ elevate levels of both adenosine 3′,5′monophosphate (cyclic AMP) and guanosine 3′,5′monophosphate (cyclic GMP) in incubated slices of mouse cerebellum. Calcium is an essential requirement for the K+ -induc
Autor:
Douglas F. Covey, Cathy L. Bell-Horner, Eric B. Gonzales, James A. Ferrendelli, Glenn H. Dillon, Maria Antonette M. de la Cruz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:677-683
Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABA(A) receptors. Lactones with small alkyl substitutions at the alpha-position positively modulate the channel, whereas beta-substituted lactones tend to inhibit the G
Autor:
James A. Ferrendelli, L. Magnus, Ilo E. Leppik, Jacqueline A. French, J. Han, Martha J. Morrell
Publikováno v:
Epilepsy Research. 54:153-161
Purpose : Three randomized, placebo-controlled trials have demonstrated the safety and efficacy of levetiracetam, a new antiepileptic medication, as add-on therapy for partial-onset seizures. The purpose of this study was to gather additional safety
Autor:
B. C. H. Hsiang, James A. Ferrendelli, Luzviminda V. Tinao-Wooldridge, Tammy Latifi, Douglas F. Covey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:265-270
4,7,7-Trimethyl-6,8-dioxabicyclo[3.2.1]octan-2-one was found to be an effective anticonvulsant (ED 50 = 131 mg/kg) against pentylenetetrazole-induced seizures in mice. Enantioselectively was observed in the actions of the (+)- and (−)-enantiomers a
Autor:
James A. Ferrendelli, Katherine D. Holland, Gregory C. Mathews, Keith E. Isenberg, Annabel M. Bolos-Sy, Steven M. Rothman, Douglas F. Covey
Publikováno v:
Neuron. 13:149-158
Although we now have extensive knowledge about the GABA A receptor subunits determining benzodiazepine modulation of channel function, little is known about subunits influencing other modulatory sites on the GABA A receptor-chloride channel complex.
Autor:
James A. Ferrendelli
Publikováno v:
Epilepsia. 42:28-30
A number of commonly used antiepileptic drugs (AEDs) produce severe adverse effects if they are introduced at their usual daily maintenance doses. Gradual slow titration of the dose often avoids these adverse effects almost entirely. Conversely, some
Autor:
Douglas F. Covey, J. A. Levine, K. D. Holland, James A. Ferrendelli, D. J. Canney, A. C. Mckeon
Publikováno v:
ChemInform. 22
Autor:
A. C. Mckeon, K. Xu, James A. Ferrendelli, K. D. Holland, Steven M. Rothman, E. M. Peterson, Douglas F. Covey
Publikováno v:
ChemInform. 25
Autor:
Douglas F. Covey, Tammy Latifi, L. V. Tinao‐Wooldridge, B. C. H. Hsiang, James A. Ferrendelli
Publikováno v:
ChemInform. 26
Autor:
K. E. Woodward, Douglas F. Covey, Steven M. Rothman, P. A. Reddy, Tammy Latifi, M. W. Hill, B. C. H. Hsiang, James A. Ferrendelli
Publikováno v:
ChemInform. 27
A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones (lactams) have been prepared and evaluated for their anticonvulsant activities. In the pentylenetetrazole mouse seizure model, 3,3-diethyl lactam 7c and 3-benzyl-3-ethyl lacta