Zobrazeno 1 - 10
of 325
pro vyhledávání: '"James A. Ferrendelli"'
Publikováno v:
Journal of Neurochemistry. 26:741-748
—Depolarizing concentrations of K+ elevate levels of both adenosine 3′,5′monophosphate (cyclic AMP) and guanosine 3′,5′monophosphate (cyclic GMP) in incubated slices of mouse cerebellum. Calcium is an essential requirement for the K+ -induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f13f24260329bc5d2228d12b2a9ee6
https://doi.org/10.1111/j.1471-4159.1976.tb04446.x-i1
https://doi.org/10.1111/j.1471-4159.1976.tb04446.x-i1
Autor:
Douglas F. Covey, Cathy L. Bell-Horner, Eric B. Gonzales, James A. Ferrendelli, Glenn H. Dillon, Maria Antonette M. de la Cruz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:677-683
Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABA(A) receptors. Lactones with small alkyl substitutions at the alpha-position positively modulate the channel, whereas beta-substituted lactones tend to inhibit the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7089e65d5aaef4ae91e3c705f9a97b56
https://doi.org/10.1124/jpet.103.063008
https://doi.org/10.1124/jpet.103.063008
Autor:
James A. Ferrendelli, L. Magnus, Ilo E. Leppik, Jacqueline A. French, J. Han, Martha J. Morrell
Publikováno v:
Epilepsy Research. 54:153-161
Purpose : Three randomized, placebo-controlled trials have demonstrated the safety and efficacy of levetiracetam, a new antiepileptic medication, as add-on therapy for partial-onset seizures. The purpose of this study was to gather additional safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ea73180dd5cc877fbebef9cd7e8308
https://doi.org/10.1016/s0920-1211(03)00080-9
https://doi.org/10.1016/s0920-1211(03)00080-9
Autor:
B. C. H. Hsiang, James A. Ferrendelli, Luzviminda V. Tinao-Wooldridge, Tammy Latifi, Douglas F. Covey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:265-270
4,7,7-Trimethyl-6,8-dioxabicyclo[3.2.1]octan-2-one was found to be an effective anticonvulsant (ED 50 = 131 mg/kg) against pentylenetetrazole-induced seizures in mice. Enantioselectively was observed in the actions of the (+)- and (−)-enantiomers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc012aac2b8b3175eddbfc752a9a90f8
https://doi.org/10.1016/0960-894x(95)00021-k
https://doi.org/10.1016/0960-894x(95)00021-k
Autor:
James A. Ferrendelli, Katherine D. Holland, Gregory C. Mathews, Keith E. Isenberg, Annabel M. Bolos-Sy, Steven M. Rothman, Douglas F. Covey
Publikováno v:
Neuron. 13:149-158
Although we now have extensive knowledge about the GABA A receptor subunits determining benzodiazepine modulation of channel function, little is known about subunits influencing other modulatory sites on the GABA A receptor-chloride channel complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31888a0f55e7c2f6081d602c8959a16
https://doi.org/10.1016/0896-6273(94)90465-0
https://doi.org/10.1016/0896-6273(94)90465-0
Autor:
James A. Ferrendelli
Publikováno v:
Epilepsia. 42:28-30
A number of commonly used antiepileptic drugs (AEDs) produce severe adverse effects if they are introduced at their usual daily maintenance doses. Gradual slow titration of the dose often avoids these adverse effects almost entirely. Conversely, some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a47c610763817b3a0a3941bee3dbc4
https://doi.org/10.1046/j.1528-1157.2001.0420s4028.x
https://doi.org/10.1046/j.1528-1157.2001.0420s4028.x
Autor:
Douglas F. Covey, J. A. Levine, K. D. Holland, James A. Ferrendelli, D. J. Canney, A. C. Mckeon
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83856496573b908bdc90cd65557a1ff3
https://doi.org/10.1002/chin.199144152
https://doi.org/10.1002/chin.199144152
Autor:
A. C. Mckeon, K. Xu, James A. Ferrendelli, K. D. Holland, Steven M. Rothman, E. M. Peterson, Douglas F. Covey
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79deca739f2a361f8766802a1da4cd2f
https://doi.org/10.1002/chin.199420140
https://doi.org/10.1002/chin.199420140
Autor:
Douglas F. Covey, Tammy Latifi, L. V. Tinao‐Wooldridge, B. C. H. Hsiang, James A. Ferrendelli
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee3f042516ad20d1f2bdf14b70f356f
https://doi.org/10.1002/chin.199527266
https://doi.org/10.1002/chin.199527266
Autor:
K. E. Woodward, Douglas F. Covey, Steven M. Rothman, P. A. Reddy, Tammy Latifi, M. W. Hill, B. C. H. Hsiang, James A. Ferrendelli
Publikováno v:
ChemInform. 27
A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones (lactams) have been prepared and evaluated for their anticonvulsant activities. In the pentylenetetrazole mouse seizure model, 3,3-diethyl lactam 7c and 3-benzyl-3-ethyl lacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d050c0877aaf4b8de658dde99cde656a
https://doi.org/10.1002/chin.199633131
https://doi.org/10.1002/chin.199633131