Zobrazeno 1 - 10
of 437
pro vyhledávání: '"James A. Driscoll"'
Autor:
Ehsan Malek, Priyanka S. Rana, Muthulekha Swamydas, Michael Daunov, Masaru Miyagi, Elena Murphy, James J. Ignatz-Hoover, Leland Metheny, Seong Jin Kim, James J. Driscoll
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary end
Externí odkaz:
https://doaj.org/article/2986c29d1e41419b91ddff1528ad8605
Autor:
Sindhuja Senigarapu, James J. Driscoll
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Cardiac amyloidosis (CA) is a serious condition that results in infiltrative cardiomyopathy and heart failure with preserved ejection fraction (HFpEF) that is caused by the extracellular deposition of amyloid fibrils within heart tissue. While many i
Externí odkaz:
https://doaj.org/article/4d12bcf1905d4611b723bdce70a7ff5f
Autor:
Caroline D. Cappello, Kenneth V. Jacobson, James T. Driscoll, Kyle M. McCarty, Javan M. Bauder
Publikováno v:
Ecosphere, Vol 15, Iss 10, Pp n/a-n/a (2024)
Abstract Evaluating population responses to management is a crucial component of successful conservation programs. Models predicting population growth under different management scenarios can provide key insights into the efficacy of specific managem
Externí odkaz:
https://doaj.org/article/72de9d60c4cb4d34abe15cb3c38d5058
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Pathways that govern cellular bioenergetics are deregulated in tumor cells and represent a hallmark of cancer. Tumor cells have the capacity to reprogram pathways that control nutrient acquisition, anabolism and catabolism to enhance their growth and
Externí odkaz:
https://doaj.org/article/9c06a4f5c4cc4242b8cdc48875485fb0
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-17 (2022)
Abstract Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of malignant plasma cells nurtured within a permissive bone marrow microenvironment. While patients mount numerous adaptive immune responses directed against th
Externí odkaz:
https://doaj.org/article/283eab1ea8d14ef384b8795692d76d60
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Multiple myeloma (MM) remains a lethal hematologic cancer characterized by the expansion of transformed plasma cells within the permissive bone marrow (BM) milieu. The emergence of relapsed and/or refractory MM (RRMM) is provoked through clonal evolu
Externí odkaz:
https://doaj.org/article/657ac2031ff84ad584225c127a402a08
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A deeper understanding of basic immunology principles and advances in bioengineering have accelerated the mass production of genetically-reprogrammed T-cells as living drugs to treat human diseases. Autologous and allogeneic cytotoxic T-cells have be
Externí odkaz:
https://doaj.org/article/de1386d3dd10474c93908ed530cb3b96
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Essential core pathways of cellular biology are preserved throughout evolution, highlighting the importance of these pathways for both bacteria and human cancer cells alike. Cell viability requires a proper balance between protein synthesis and degra
Externí odkaz:
https://doaj.org/article/7f3fe2f4923a424e81ddee7a79811898
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-20 (2021)
Abstract The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tu
Externí odkaz:
https://doaj.org/article/afba89148a4e4632b3b724c4d1fd6e49
Autor:
Yunseok Choi, James F. Driscoll
Publikováno v:
Journal of Propulsion and Power. :1-13
A flowpath geometry was computed that improves the specific impulse of a dual-mode scramjet engine in a generic X-51 hypersonic vehicle. Six parameters were varied: inlet contraction ratio, the diameters and numbers of fuel injectors, divergence angl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a7e9f150a03e87ee45bcfdd98c55616
https://doi.org/10.2514/1.b38931
https://doi.org/10.2514/1.b38931