Zobrazeno 1 - 10
of 660
pro vyhledávání: '"James A. Carson"'
Autor:
Deena B. Snoke, Emma Bellefleur, Hibba Tul Rehman, James A. Carson, Matthew E. Poynter, Kim L. Dittus, Michael J. Toth
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2579-2590 (2023)
Abstract Background Cancer and its treatment can adversely affect skeletal muscle, impacting physical function, treatment response and survival. No studies, however, have comprehensively characterized these muscle adaptations longitudinally in human
Externí odkaz:
https://doaj.org/article/549d87eced324256bf75e7517991059f
Autor:
Jessica L. Halle, Brittany R. Counts, Quan Zhang, Kylie M. James, Melissa J. Puppa, Stephen E. Alway, James A. Carson
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is a treatment for colorectal cancer that can induce persistent fatigue and metabolic dysfunction. Regular exercise after chemotherapy cessation is widely recommended for cancer patients a
Externí odkaz:
https://doaj.org/article/a422104a9ef741ec9c035ac360f40486
Autor:
Stephen E. Alway, Hector G. Paez, Christopher R. Pitzer, Peter J. Ferrandi, Mohammad Moshahid Khan, Junaith S. Mohamed, James A. Carson, Michael R. Deschenes
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 493-507 (2023)
Abstract Background Injection of exogenous mitochondria has been shown to improve the ischaemia‐damaged myocardium, but the effect of mitochondrial transplant therapy (MTT) to restore skeletal muscle mass and function has not been tested following
Externí odkaz:
https://doaj.org/article/57fe6d62425c4ae591b40a139a06743d
Publikováno v:
Sports Medicine and Health Science, Vol 2, Iss 4, Pp 186-194 (2020)
Cancer cachexia is a progressive disorder characterized by body weight, fat, and muscle loss. Cachexia induces metabolic disruptions that can be analogous and distinct from those observed in cancer, obscuring both diagnosis and treatment options. Inf
Externí odkaz:
https://doaj.org/article/98b6464ec14849c581f3c07097fcd8d0
Publikováno v:
Sports Medicine and Health Science, Vol 2, Iss 1, Pp 1-6 (2020)
Low-grade inflammation is emerging as a common feature of contemporary metabolic, psychiatric, and neurodegenerative diseases. Both physical inactivity and abdominal adiposity are associated with persistent systemic low-grade inflammation. Thus, the
Externí odkaz:
https://doaj.org/article/aa7eda6397ce40f59bf4d18fa807c1b0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Preclinical models and in vitro experiments have provided valuable insight into the regulation of cancer-induced muscle wasting. Colon-26 (C26) tumor cells induce cachexia in mice, and conditioned media (CM) from these cells promotes myotube atrophy
Externí odkaz:
https://doaj.org/article/621b3836282a432db7d70fdce206b8b9
Autor:
Dennis K. Fix, Brittany R. Counts, Ashley J. Smuder, Mark A. Sarzynski, Ho‐Jin Koh, James A. Carson
Publikováno v:
Physiological Reports, Vol 9, Iss 14, Pp n/a-n/a (2021)
Abstract Disruptions to muscle protein turnover and metabolic regulation contribute to muscle wasting during the progression of cancer cachexia. The initiation of cachexia is also associated with decreased physical activity. While chronic muscle AMPK
Externí odkaz:
https://doaj.org/article/20a1408e1a464ed895249deea100592a
Autor:
Brandon N. VanderVeen, Alexander T. Sougiannis, Kandy T. Velazquez, James A. Carson, Daping Fan, E. Angela Murphy
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
5 fluorouracil (5FU) has been a first-choice chemotherapy drug for several cancer types (e.g., colon, breast, head, and neck); however, its efficacy is diminished by patient acquired resistance and pervasive side effects. Leukopenia is a hallmark of
Externí odkaz:
https://doaj.org/article/88de4819727b4709bd396a7224ad9829
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a common comorbidity associated with cancer that results in adverse consequences for the patient related to decreased chemotherapy responsiveness and increased mortali
Externí odkaz:
https://doaj.org/article/8f73e930a7bf406f973c8473da48d20f
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Cancer cachexia is a multifactorial muscle wasting condition characterized by severe body weight and muscle mass loss which is secondary to chronic disease. The mechanistic examination of cachexia has predominately focused on the male phenotype and c
Externí odkaz:
https://doaj.org/article/3ad5264966b7458c8655a263bec4bc7e