Zobrazeno 1 - 10
of 467
pro vyhledávání: '"James A. Bruce"'
Autor:
Ryan T. Behrens, Jyothi Krishnaswamy Rajashekar, James W. Bruce, Edward L. Evans, Amelia M. Hansen, Natalia Salazar-Quiroz, Lacy M. Simons, Paul Ahlquist, Judd F. Hultquist, Priti Kumar, Nathan M. Sherer
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (ex
Externí odkaz:
https://doaj.org/article/e49508a9b94142c094747a11d2fbff48
Autor:
James W Bruce, Eunju Park, Chris Magnano, Mark Horswill, Alicia Richards, Gregory Potts, Alexander Hebert, Nafisah Islam, Joshua J Coon, Anthony Gitter, Nathan Sherer, Paul Ahlquist
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011492 (2023)
HIV-1 spreads efficiently through direct cell-to-cell transmission at virological synapses (VSs) formed by interactions between HIV-1 envelope proteins (Env) on the surface of infected cells and CD4 receptors on uninfected target cells. Env-CD4 inter
Externí odkaz:
https://doaj.org/article/77912a6a980f4e69bc18ea2183c19415
Autor:
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C. Kolwicz Jr., Wang Wang, James E. Bruce, Rong Tian
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for the switch are
Externí odkaz:
https://doaj.org/article/42430db1c8a448f4bb8c08df2e4cb07e
Autor:
Henry Claireaux, Richard Goodall, Joshua Hill, Elizabeth Wilson, Philippa Coull, Sebastian Green, James Schuster-Bruce, Diana Lim, Joanna Miles, Payam Tarassoli
Publikováno v:
Chinese Journal of Traumatology, Vol 22, Iss 5, Pp 249-254 (2019)
Purpose: Supracondylar fractures of the humerus cause significant morbidity in children. Nerve damage and loss of fracture reduction are common recognised complications in patients with this injury. Uncertainty surrounds the optimal Kirschner wire co
Externí odkaz:
https://doaj.org/article/0cf4a1e3a2004b1ba49dbe0b5a139013
Autor:
Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Phosphorylation of Tyr313 in Hsp90 enhances the binding to its activator Aha1, but the underlying mechanism is unknown. Here, the authors study the structural consequences of Tyr313 phosphorylation, showing that it serves as a conformational switch i
Externí odkaz:
https://doaj.org/article/c98ae81e4f7740939a33040bfaf94c2e
Autor:
Denis Horgan, Dagmar Führer-Sakel, Paula Soares, Clara V. Alvarez, Laura Fugazzola, Romana T. Netea-Maier, Barbara Jarzab, Marta Kozaric, Beate Bartes, James Schuster-Bruce, Luigino Dal Maso, Martin Schlumberger, Furio Pacini
Publikováno v:
Healthcare, Vol 10, Iss 9, p 1621 (2022)
Thyroid cancer (TC) is the most common malignancy of the endocrine system that affects the thyroid gland. It is usually treatable and, in most cases, curable. The central issues are how to improve knowledge on TC, to accurately identify cases at an e
Externí odkaz:
https://doaj.org/article/47bcda19d0bf4390aeba6cf75f92e559
Autor:
Anna A. Bakhtina, Gavin A. Pharaoh, Matthew D. Campbell, Andrew Keller, Rudolph S. Stuppard, David J. Marcinek, James E. Bruce
Publikováno v:
Nature Aging. 3:313-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5642f8c4f74d87a13b5ed65512be31
https://doi.org/10.1038/s43587-023-00366-5
https://doi.org/10.1038/s43587-023-00366-5
Autor:
Matthew A. Walker, Juan Chavez, Outi Villet, Xiaoting Tang, Andrew Keller, James E. Bruce, Rong Tian
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively co
Externí odkaz:
https://doaj.org/article/38a7738718cd42c8bbb9eef873beabad
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009364 (2021)
Previously, we reported that cellular transcription factor ZASC1 facilitates DNA-dependent/RNA-independent recruitment of HIV-1 TAT and the cellular elongation factor P-TEFb to the HIV-1 promoter and is a critical factor in regulating HIV-1 transcrip
Externí odkaz:
https://doaj.org/article/323b5eda2ca849d18742082572e16559
Autor:
Kapil Sugand, Ramla Ali, Richard Goodall, Justin Salciccioli, Dominic Marshall, James Schuster-Bruce, Hani B Abdul-Jabar, Joseph Shalhoub
Publikováno v:
Injury. 54:645-651
Neck of femur fractures (NOFF) pose significant socio-economic costs to society with a high degree of morbidity and mortality. Its incidence rate has been collated within the Global Burden of Disease (GBD) database; however, to date, no comparison ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b075e188a3527632838f8eb1b19b8982
https://doi.org/10.1016/j.injury.2022.11.038
https://doi.org/10.1016/j.injury.2022.11.038