Zobrazeno 1 - 6
of 6
pro vyhledávání: '"James A. Beswick"'
Autor:
Paula I. Seoane, James A. Beswick, Andrew G. Leach, Tessa Swanton, Lucy V. Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The NLRP3 inflammasome is a component of the inflammatory response to infection and injury, orchestrating the maturation and release of the pro-inflammatory cytokines interleukin-1β (IL-1β), IL-18, and triggering pyroptotic cell death. App
Externí odkaz:
https://doaj.org/article/38f74ab91955427e865abe6c6a9ba28b
Autor:
Stephane de Cesco, Daniel Williams, Lucy V Morris, Lina Y El-Sharkawy, Tessa Swanton, Halah Hammadi, Catherine B. Lawrence, Jack Peter Green, David Brough, Shi Yu, Sally Freeman, James A Beswick, John B. Davis
Publikováno v:
Swanton, T, Beswick, J, Hammadi, H, Morris, L, Williams, D, De Cesco, S, El-sharkawy, L, Yu, S, Green, J, Davis, J, Lawrence, C, Brough, D & Freeman, S 2020, ' Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl-channel modulation ', Chemical Science, vol. 11, no. 43, pp. 11720-11728 . https://doi.org/10.1039/D0SC03828H
Chemical Science
Chemical Science
The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a8b9179397a434db4dd5074272628
https://doi.org/10.1039/d0sc03828h
https://doi.org/10.1039/d0sc03828h
Autor:
Sally Freeman, James A Beswick, David Brough, Tessa Swanton, James Cook, Catherine B. Lawrence
Publikováno v:
Swanton, T, Cook, J, Beswick, J, Freeman, S, Lawrence, C B & Brough, D 2018, ' Is targeting the inflammasome a way forward for neuroscience drug discovery? ', SLAS Discovery . https://doi.org/10.1177/2472555218786210
Neuroinflammation is becoming increasingly recognized as a critical factor in the pathology of both acute and chronic neurological conditions. Inflammasomes such as the one formed by NACHT, LRR, and PYD domains containing protein 3 (NLRP3) are key re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbf2c42d40ead616f255c9148ac7116
https://doi.org/10.1177/2472555218786210
https://doi.org/10.1177/2472555218786210
Autor:
Antony Adamson, Tessa Swanton, Catherine B. Lawrence, Shi Yu, Richard A. Bryce, Sally Freeman, David Brough, Lina Y El-Sharkawy, Jack Peter Green, Lucy V Morris, James Cook, James A Beswick, Neil E. Humphreys
Publikováno v:
eLife
eLife, Vol 9 (2020)
Green, J, Swanton, T, Morris, L, El-Sharkawy, L, Cook, J, Yu Shi, A, Beswick, J, Adamson, A, Humphreys, N, Bryce, R, Freeman, S, Lawrence, C B & Brough, D 2020, ' LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ', eLife, vol. 2020, no. 9, e59704 . https://doi.org/10.7554/eLife.59704
eLife, Vol 9 (2020)
Green, J, Swanton, T, Morris, L, El-Sharkawy, L, Cook, J, Yu Shi, A, Beswick, J, Adamson, A, Humphreys, N, Bryce, R, Freeman, S, Lawrence, C B & Brough, D 2020, ' LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ', eLife, vol. 2020, no. 9, e59704 . https://doi.org/10.7554/eLife.59704
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a230cebaafbd78209469337b11d79a9
https://doi.org/10.7554/elife.59704
https://doi.org/10.7554/elife.59704
Autor:
Shi Yu, Sally Freeman, James Cook, Neil E. Humphreys, Richard A. Bryce, James A Beswick, David Brough, Antony Adamson, Tessa Swanton, Jack Peter Green, Lucy V Morris, Catherine E. Lawrence, Lina Y El-Sharkawy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d6287f405f4cfcf90a9e2e65d6d9a7
https://doi.org/10.7554/elife.59704.sa2
https://doi.org/10.7554/elife.59704.sa2
Autor:
Neil E. Humphreys, James A Beswick, James Cook, Tessa Swanton, Jack Peter Green, Catherine E. Lawrence, Lina Y El-Sharkawy, Antony Adamson, Shi Yu, Sally Freeman, Lucy V Morris, David Brough, Richard A. Bryce
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b251bb08e1c5c41a5e21fa0b789ddfe
https://doi.org/10.1101/2020.06.11.146225
https://doi.org/10.1101/2020.06.11.146225