Zobrazeno 1 - 10
of 201
pro vyhledávání: '"James A. Bear"'
Autor:
Evan DuBose, Samantha M. Bevill, Dana K. Mitchell, Noah Sciaky, Brian T. Golitz, Shelley A. H. Dixon, Steven D. Rhodes, James E. Bear, Gary L. Johnson, Steven P. Angus
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionApproximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss-of-function mutations oc
Externí odkaz:
https://doaj.org/article/858ea32fd4334cda9da5e4e67522fa6f
Autor:
Jamie L Nosbisch, Anisur Rahman, Krithika Mohan, Timothy C Elston, James E Bear, Jason M Haugh
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007708 (2020)
Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/
Externí odkaz:
https://doaj.org/article/38c879e4765f4fdea7a92e4d6401cb93
Autor:
David S. Paul, Caterina Casari, Congying Wu, Raymond Piatt, Swetha Pasala, Robert A. Campbell, Kathryn O. Poe, Dorsaf Ghalloussi, Robert H. Lee, Jeremy D. Rotty, Brian C. Cooley, Kellie R. Machlus, Joseph E. Italiano, Jr, Andrew S. Weyrich, James E. Bear, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1398-1408 (2017)
Abstract: Actin reorganization regulates key processes in platelet activation. Here we examined the role of the Arp2/3 complex, an essential component in actin filament branching, in platelet function. The Arpc2 gene, encoding the p34 subunit of the
Externí odkaz:
https://doaj.org/article/44144d7cf1194f29b42a8abe4531b894
Autor:
Melissa A. Quintanilla, Hiral Patel, Huini Wu, Kem A. Sochacki, Matthew Akamatsu, Jeremy D. Rotty, Farida Korobova, James E. Bear, Justin W. Taraska, Patrick W. Oakes, Jordan R. Beach
The ability to dynamically assemble contractile networks is required throughout cell physiology, yet the biophysical mechanisms regulating non-muscle myosin 2 filament assembly in living cells are lacking. Here we use a suite of dynamic, quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762b7104d41c29c20ffbf1a201cf9adc
https://doi.org/10.1101/2023.04.26.538303
https://doi.org/10.1101/2023.04.26.538303
Autor:
Frank B. Gertler, James E. Bear, Patricia J. Keely, Douglas A. Lauffenburger, Richard O. Hynes, Kari B. Wisinski, Michael J. Cima, Robert Langer, Duanduan Ma, Charlie Whittaker, Sreeja B. Asokan, John M. Lamar, Daisy Riquelme, Jeff Wyckoff, Bruna C. Guido, Liliane C. Broye, Tatsiana Kosciuk, Oliver Jonas, Madeleine J. Oudin
Supplementary Figure S5. Mena isoform expression does not affect Integrin alphav, beta1 or FAK levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff0ee4083e33a04f07af4a23a9cba3
https://doi.org/10.1158/2159-8290.22531394
https://doi.org/10.1158/2159-8290.22531394
Autor:
Frank B. Gertler, James E. Bear, Patricia J. Keely, Douglas A. Lauffenburger, Richard O. Hynes, Kari B. Wisinski, Michael J. Cima, Robert Langer, Duanduan Ma, Charlie Whittaker, Sreeja B. Asokan, John M. Lamar, Daisy Riquelme, Jeff Wyckoff, Bruna C. Guido, Liliane C. Broye, Tatsiana Kosciuk, Oliver Jonas, Madeleine J. Oudin
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cccb7933131f12f4e83628ea9829270
https://doi.org/10.1158/2159-8290.22531409.v1
https://doi.org/10.1158/2159-8290.22531409.v1
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Expanded detail on MIB MS experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2c066efb2308edfb15303cc7f4e858
https://doi.org/10.1158/0008-5472.22418124
https://doi.org/10.1158/0008-5472.22418124
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Structural reorganization and amelanotic intratumoral nests are evident in persistent melanoma on MEKi.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a4e87ab2bd3ad8eff0f6219dfe75f1
https://doi.org/10.1158/0008-5472.22418130.v1
https://doi.org/10.1158/0008-5472.22418130.v1
Autor:
Chad V. Pecot, Leaf Huang, Michael B. Major, Pierre P. Massion, Scott H. Randell, Sarah Cohen, James E. Bear, Teresa Mascenik, Tyler J. Goodwin, Devon G. Allen, Stephanie M. Cohen, Amanda E.D. Van Swearingen, Trent A. Waugh, Nicholas Mckenzie, Menglin Wang, Subrata K. Ghosh, Ian A. Windham, Salma H. Azam, Gabriella Yacovone, Adam R. Belanger, Brittany M. Bowman, Alessandro Porrello, Emily B. Harrison
Expression of miRs in SK-MES-1 and LN1 measured by Nanostring with normalized counts greater than 5 in at least one of the two compared samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f05aedbac0d51d5815c9a444c8cc3
https://doi.org/10.1158/0008-5472.22425600
https://doi.org/10.1158/0008-5472.22425600
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Kinome and transcriptome responses to combined BRAF and MEK inhibition in murine tumors, patient samples, and human cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7752ce357e3add8e25523de79714aa
https://doi.org/10.1158/0008-5472.22418118
https://doi.org/10.1158/0008-5472.22418118