Zobrazeno 1 - 10
of 919
pro vyhledávání: '"James A. Alexander"'
Autor:
Robert W. Perry, Benjamin H. Mullish, James L. Alexander, Raashi Shah, Nathan P. Danckert, Jesus Miguens Blanco, Lauren Roberts, Zhigang Liu, Despoina Chrysostomou, Shiva T. Radhakrishnan, Sharmili Balarajah, Rachael Barry, Lucy C. Hicks, Horace R. T. Williams, Julian R. Marchesi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Investigating the gut microbiome and metabolome frequently requires faecal samples, which can be difficult to obtain. Previous studies have shown that rectal swabs are comparable to faecal samples for analysing gut microbiota composition and
Externí odkaz:
https://doaj.org/article/2884c53508e64f8f9e17d15c3f4d832c
Autor:
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Immune checkpoint inhibitors (CPIs) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy
Externí odkaz:
https://doaj.org/article/e664d0e3c68643ff903f07ec1b951c4e
Autor:
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Method
Externí odkaz:
https://doaj.org/article/12e07005f08c4eff961ce1c2bc1eb63e
Autor:
Shiva T. Radhakrishnan, Kate I. Gallagher, Benjamin H. Mullish, Jose I. Serrano-Contreras, James L. Alexander, Jesus Miguens Blanco, Nathan P. Danckert, Maria Valdivia-Garcia, Billy J. Hopkins, Anik Ghai, Azad Ayub, Jia V. Li, Julian R. Marchesi, Horace R. T. Williams
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Faecal or biopsy samples are frequently used to analyse the gut microbiota, but issues remain with the provision and collection of such samples. Rectal swabs are widely-utilised in clinical practice and previous data demonstrate their potent
Externí odkaz:
https://doaj.org/article/156d4acd5eb94b2090a2d74afc916df8
Autor:
Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams, Timothy R. Orchard
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogenesis these conditions.
Externí odkaz:
https://doaj.org/article/bd479af395644bdb902270d2ec762c46
Autor:
Simeng Lin, Nicholas A. Kennedy, Aamir Saifuddin, Diana Muñoz Sandoval, Catherine J. Reynolds, Rocio Castro Seoane, Sherine H. Kottoor, Franziska P. Pieper, Kai-Min Lin, David K. Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J. McDonald, Shaji Sebastian, James L. Alexander, Laura Constable, James C. Lee, Charles D. Murray, Ailsa L. Hart, Peter M. Irving, Gareth-Rhys Jones, Klaartje B. Kok, Christopher A. Lamb, Charlie W. Lees, Daniel M. Altmann, Rosemary J. Boyton, James R. Goodhand, Nick Powell, Tariq Ahmad, CLARITY IBD study
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses
Externí odkaz:
https://doaj.org/article/ff70757914a74e03bae010a63c866cc8
Autor:
Christian J Barton, Kay M Crossley, Matthew G King, Anthony G Schache, Adam I Semciw, James L Alexander, Brooke E Patterson, Danilo De Oliveira Silva, Adam G Culvenor, Stuart J Warden, Edwin H Oei, Michael Girdwood, Andrea M Bruder, Benjamin F Mentiplay, David L Carey, Richard T R Johnston, Richard B Souza, Joshua P Hill, Prasanna Sritharan, Valentina Pedoia, Melissa J Haberfield, Thomas J West, Paula J Pappalardo, Connie Briggs, Gustavo F Telles, Michael P Hedger, Mark Hulett
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Introduction Running is one of the most popular recreational activities worldwide, due to its low cost and accessibility. However, little is known about the impact of running on knee joint health in runners with and without a history of knee surgery.
Externí odkaz:
https://doaj.org/article/6d8253093b7c44728261293851786d3f
Autor:
James L. Alexander, Benjamin H. Mullish, Nathan P. Danckert, Zhigang Liu, Marton L. Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A. Roberts, Claire M. Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W. Lees, Julian P. Teare, Ailsa Hart, James R. Goodhand, Nicholas A. Kennedy, Tamas Korcsmaros, Julian R. Marchesi, Tariq Ahmad, Nick Powell
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104430- (2023)
Summary: Background: Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturb
Externí odkaz:
https://doaj.org/article/81748891479c4744b4c014c27869b064
Akademický článek
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Autor:
Alice Nishigaki, Renato Previdelli, James L. Alexander, Sharmili Balarajah, Lauren Roberts, Julian R. Marchesi
Publikováno v:
Animals, Vol 13, Iss 17, p 2807 (2023)
Stool sampling is a useful tool for diagnosing gastrointestinal disease in veterinary medicine. The sub-clinical disease burden of Salmonella spp. in cattle can become significant for farmers. However, current methods of faecal sampling in a rural se
Externí odkaz:
https://doaj.org/article/fd5ea9b84d414f8bb11ea17686b02c39