Zobrazeno 1 - 10
of 477
pro vyhledávání: '"James A. McCubrey"'
Autor:
Alessandro Lavoro, Luca Falzone, Giuseppe Gattuso, Giuseppe N. Conti, Rosario Caltabiano, Gabriele Madonna, Mariaelena Capone, James A. McCubrey, Paolo A. Ascierto, Massimo Libra, Saverio Candido
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) is gaining growing in
Externí odkaz:
https://doaj.org/article/aceb0e12d2e74b42a6c2049cf1cf8200
Autor:
Antonietta Fazio, Irene Neri, Foteini-Dionysia Koufi, Maria Vittoria Marvi, Andrea Galvani, Camilla Evangelisti, James A. McCubrey, Lucio Cocco, Lucia Manzoli, Stefano Ratti
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6592 (2024)
Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with endothelial cells. These cells are known for their intriguing properties due to their heterogenei
Externí odkaz:
https://doaj.org/article/3fb2bf99c3554c7884997f2c480bb881
Autor:
Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli, Lucio Cocco, Matilde Y. Follo
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives. Among hematological c
Externí odkaz:
https://doaj.org/article/c109ec95839b4454ba98608885f40f32
Autor:
Saverio Candido, Barbara Tomasello, Alessandro Lavoro, Luca Falzone, Giuseppe Gattuso, Angela Russo, Sabrina Paratore, James A. McCubrey, Massimo Libra
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Several features of cancer cells such as proliferation, invasion, metastatic spreading, and drug resistance are affected by their interaction with several tumor microenvironment (TME) components, including neutrophil gelatinase-associated lipocalin (
Externí odkaz:
https://doaj.org/article/c7eeb430f6894e2f8650e5799ce87227
Autor:
Maria Vittoria Marvi, Irene Neri, Camilla Evangelisti, Giulia Ramazzotti, Sofia Asioli, Matteo Zoli, Diego Mazzatenta, Niccolò Neri, Luca Morandi, Caterina Tonon, Raffaele Lodi, Enrico Franceschi, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Stefano Ratti
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 798 (2023)
Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate differe
Externí odkaz:
https://doaj.org/article/8f90fbd61b89494abd39e1e1bf4e8a0f
Autor:
Alberto M. Martelli, Francesca Paganelli, Serena Truocchio, Carla Palumbo, Francesca Chiarini, James A. McCubrey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2962 (2023)
The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and vertebrate embryonic development. Along with other networks, such as NOTCH and WNT, HH signaling specifies both the early patterning and the polarity events as well
Externí odkaz:
https://doaj.org/article/e59cadd6d6984543b109ab90c46f5c22
Autor:
Stefano Ratti, Matilde Y. Follo, Giulia Ramazzotti, Irene Faenza, Roberta Fiume, Pann-Ghill Suh, James A. McCubrey, Lucia Manzoli, Lucio Cocco
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 312-317 (2019)
Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways related to critical cellular functions, such as cell cycle regulation, cell differentiation, and gene expression. Nuclear PI-PLCs have been studied as key enzymes
Externí odkaz:
https://doaj.org/article/88d7efc6a4b14319ab4215de5f83d1d6
Autor:
James A. McCubrey, Li V. Yang, Stephen L. Abrams, Linda S. Steelman, Matilde Y. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppa Augello, Melchiorre Cervello
Publikováno v:
Cells, Vol 11, Iss 14, p 2155 (2022)
Approximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are largely ineffective due to the dense desmoplastic tumor microenvironment which p
Externí odkaz:
https://doaj.org/article/4331f5d461c746a0aacfcd0c54461ebf
Autor:
Alberto M. Martelli, Francesca Paganelli, Camilla Evangelisti, Francesca Chiarini, James A. McCubrey
Publikováno v:
Cells, Vol 11, Iss 11, p 1812 (2022)
Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously expressed, multifunctional serine/threonine protein kinase involved in the regulation of a variety of physiological processes. GSK-3 comprises two isoforms (α and β) wh
Externí odkaz:
https://doaj.org/article/bb961d77fbac48859cbd25d9fd809e37
Autor:
Manuela Labbozzetta, Paola Poma, Marco Tutone, James A. McCubrey, Maurizio Sajeva, Monica Notarbartolo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 356 (2022)
Drug resistance is the ability of cancer cells to gain resistance to both conventional and novel chemotherapy agents, and remains a major problem in cancer therapy. Resistance mechanisms are multifactorial and involve more strictly pharmacological fa
Externí odkaz:
https://doaj.org/article/69662fe4238049a9a7b692117f454132