Zobrazeno 1 - 10
of 1 351
pro vyhledávání: '"James A Wells"'
Autor:
Lisa L Kirkemo, Susanna K Elledge, Jiuling Yang, James R Byrnes, Jeff E Glasgow, Robert Blelloch, James A Wells
Publikováno v:
eLife, Vol 11 (2022)
Characterization of cell surface proteome differences between cancer and healthy cells is a valuable approach for the identification of novel diagnostic and therapeutic targets. However, selective sampling of surface proteins for proteomics requires
Externí odkaz:
https://doaj.org/article/2788c63fd6b14a199fa51148956ffdd4
Autor:
Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, James S Fraser
Publikováno v:
eLife, Vol 7 (2018)
Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function.
Externí odkaz:
https://doaj.org/article/f31e59e6c613444c8e3b921c3cf0906f
Autor:
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
Publikováno v:
eLife, Vol 7 (2018)
While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on ce
Externí odkaz:
https://doaj.org/article/effb67b1d9ed4b8785dee707219f397c
Autor:
Brian C Martinson, David Nelson, Emily Hagel-Campbell, David Mohr, Martin P Charns, Ann Bangerter, Carol R Thrush, Joseph R Ghilardi, Hanna Bloomfield, Richard Owen, James A Wells
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151571 (2016)
BACKGROUND:In service to its core mission of improving the health and well-being of veterans, Veterans Affairs (VA) leadership is committed to supporting research best practices in the VA. Recognizing that the behavior of researchers is influenced by
Externí odkaz:
https://doaj.org/article/18d7c82d28614ac18b57d344099efd15
Autor:
Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider a
Externí odkaz:
https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Arginine, a semi-essential amino acid, is critical for cell growth. Typically, de novo synthesis of arginine is sufficient to support cellular processes, however, it becomes vital for cancer cells that are unable to synthesise arginine due t
Externí odkaz:
https://doaj.org/article/3027cf5bec4d42bf89f2c65de2bdf696
Autor:
Arun P Wiita, Etay Ziv, Paul J Wiita, Anatoly Urisman, Olivier Julien, Alma L Burlingame, Jonathan S Weissman, James A Wells
Publikováno v:
eLife, Vol 2 (2013)
Externí odkaz:
https://doaj.org/article/8913916f0c734366be6fd55a224b747e
Autor:
Arun P Wiita, Etay Ziv, Paul J Wiita, Anatoly Urisman, Olivier Julien, Alma L Burlingame, Jonathan S Weissman, James A Wells
Publikováno v:
eLife, Vol 2 (2013)
How cancer cells globally struggle with a chemotherapeutic insult before succumbing to apoptosis is largely unknown. Here we use an integrated systems-level examination of transcription, translation, and proteolysis to understand these events central
Externí odkaz:
https://doaj.org/article/80230b001c3643a8af6da9582b9605d8
Autor:
Thomas G. Bartholow, Paul W.W. Burroughs, Susanna K. Elledge, James R. Byrnes, Lisa L. Kirkemo, Virginia Garda, Kevin K. Leung, James A. Wells
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 199-208 (2023)
Externí odkaz:
https://doaj.org/article/467e7849bb1545af957ab89503b40167
Autor:
Lantian Lu, Wei Yang Kong, Jiahui Zhang, Farrhana Firdaus, James W. Wells, Rachel J. Stephenson, Istvan Toth, Mariusz Skwarczynski, Jazmina L. Gonzalez Cruz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Subunit vaccines hold substantial promise in controlling infectious diseases, due to their superior safety profile, specific immunogenicity, simplified manufacturing processes, and well-defined chemical compositions. One of the most important end-tar
Externí odkaz:
https://doaj.org/article/9d05d7bec5f34cd5a012036e2a7970cf