Zobrazeno 1 - 10
of 1 606
pro vyhledávání: '"James A Watson"'
Autor:
Philippe J Guérin, Nicholas J White, Mia Cokljat, James A Watson, Verena Ilona Carrara, Joel Tarning, Cintia Valeria Cruz, Camila Capriglioni, Sabrina Marcela Insaurralde, Maximo Rousseau-Portalis, Agustina Roldan, Kanoktip Puttaraksa
Publikováno v:
BMJ Global Health, Vol 9, Iss 4 (2024)
Background The COVID-19 pandemic affected all WHO member states. We compared and contrasted the COVID-19 treatment guidelines of each member state with the WHO COVID-19 therapeutic guidelines.Methods Ministries of Health or accessed National Infectio
Externí odkaz:
https://doaj.org/article/4af13eb4a79f440c9e4143db1f704d40
Autor:
James A Watson, Robert J Commons, Joel Tarning, Julie A Simpson, Alejandro Llanos Cuentas, Marcus VG Lacerda, Justin A Green, Gavin CKW Koh, Cindy S Chu, François H Nosten, Richard N Price, Nicholas PJ Day, Nicholas J White
Publikováno v:
eLife, Vol 13 (2024)
In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of ant
Externí odkaz:
https://doaj.org/article/a448849101ae42ba942170feabc3d8bf
Autor:
Sasithon Pukrittayakamee, Podjanee Jittamala, James A Watson, Borimas Hanboonkunupakarn, Pawanrat Leungsinsiri, Kittiyod Poovorawan, Kesinee Chotivanich, Germana Bancone, Cindy S Chu, Mallika Imwong, Nicholas PJ Day, Walter RJ Taylor, Nicholas J White
Publikováno v:
eLife, Vol 12 (2024)
Background: Primaquine is an 8-aminoquinoline antimalarial. It is the only widely available treatment to prevent relapses of Plasmodium vivax malaria. The 8-aminoquinolines cause dose-dependent haemolysis in glucose-6-phosphate dehydrogenase deficien
Externí odkaz:
https://doaj.org/article/e585cfc833ba4c7cb5854b2dab312fc7
Publikováno v:
PLoS Medicine, Vol 20, Iss 11, p e1004312 (2023)
In this Policy Forum article, James A. Watson and colleagues discuss recent guidelines relating to pre-referral treatment of suspected severe malaria with rectal artesunate suppositories in remote areas.
Externí odkaz:
https://doaj.org/article/ed881d8d3bd1439e80b50be2cde96092
Autor:
William HK Schilling, Podjanee Jittamala, James A Watson, Maneerat Ekkapongpisit, Tanaya Siripoon, Thundon Ngamprasertchai, Viravarn Luvira, Sasithorn Pongwilai, Cintia Cruz, James J Callery, Simon Boyd, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Mohammad Yazid Abdad, Nattaporn Piaraksa, Kanokon Suwannasin, Pongtorn Hanboonkunupakarn, Borimas Hanboonkunupakarn, Sakol Sookprome, Kittiyod Poovorawan, Janjira Thaipadungpanit, Stuart Blacksell, Mallika Imwong, Joel Tarning, Walter RJ Taylor, Vasin Chotivanich, Chunlanee Sangketchon, Wiroj Ruksakul, Kesinee Chotivanich, Mauro Martins Teixeira, Sasithon Pukrittayakamee, Arjen M Dondorp, Nicholas PJ Day, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J White, on behalf of the PLATCOV Collaborative Group
Publikováno v:
eLife, Vol 12 (2023)
Background: There is no generally accepted methodology for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment of COVID-19, but whether it has clinically significant antiviral activ
Externí odkaz:
https://doaj.org/article/e2c1da5e8a0a4bd4bce22cc5135ee7e1
Autor:
Eva Stadler, Deborah Cromer, Somya Mehra, Adeshina I Adekunle, Jennifer A Flegg, Nicholas M Anstey, James A Watson, Cindy S Chu, Ivo Mueller, Leanne J Robinson, Timothy E Schlub, Miles P Davenport, David S Khoury
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 12, p e0010990 (2022)
A key characteristic of Plasmodium vivax parasites is their ability to adopt a latent liver-stage form called hypnozoites, able to cause relapse of infection months or years after a primary infection. Relapses of infection through hypnozoite activati
Externí odkaz:
https://doaj.org/article/19bc54aa08ff458091d20a0201a490c6
Autor:
James A Watson, Robert J Commons, Joel Tarning, Julie A Simpson, Alejandro Llanos Cuentas, Marcus VG Lacerda, Justin A Green, Gavin CKW Koh, Cindy S Chu, François H Nosten, Richard N Price, Nicholas PJ Day, Nicholas J White
Publikováno v:
eLife, Vol 11 (2022)
Tafenoquine is a newly licensed antimalarial drug for the radical cure of Plasmodium vivax malaria. The mechanism of action and optimal dosing are uncertain. We pooled individual data from 1102 patients and 72 healthy volunteers studied in the pre-re
Externí odkaz:
https://doaj.org/article/f5567952f4604510b3632a25a317789f
Autor:
James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams
Publikováno v:
eLife, Vol 11 (2022)
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://doaj.org/article/5b632ded377f43c8bc16485a42752ec1
Autor:
Arjen M Dondorp, James A Watson, Marian Warsame, Nicholas White, Thomas J Peto, Marie Onyamboko, Caterina Fanello
Publikováno v:
BMJ Global Health, Vol 7, Iss 7 (2022)
Externí odkaz:
https://doaj.org/article/1119893ad77e4a79bff567c4cc44845c
Autor:
Philippe J Guérin, Alistair R D McLean, Sumayyah Rashan, AbdulAzeez Lawal, James A Watson, Nathalie Strub-Wourgaft, Nicholas J White
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 7, p e0000561 (2022)
Therapeutic efficacy in COVID-19 is dependent upon disease severity (treatment effect heterogeneity). Unfortunately, definitions of severity vary widely. This compromises the meta-analysis of randomised controlled trials (RCTs) and the therapeutic gu
Externí odkaz:
https://doaj.org/article/23e0b5a27a91497fa397153cebe1c89a