Zobrazeno 1 - 10
of 413
pro vyhledávání: '"James A Vickers"'
Autor:
Jane Alty, Lynette R. Goldberg, Eddy Roccati, Katherine Lawler, Quan Bai, Guan Huang, Aidan D Bindoff, Renjie Li, Xinyi Wang, Rebecca J. St George, Kaylee Rudd, Larissa Bartlett, Jessica M. Collins, Mimieveshiofuo Aiyede, Nadeeshani Fernando, Anju Bhagwat, Julia Giffard, Katharine Salmon, Scott McDonald, Anna E. King, James C. Vickers
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD, a 10–20-year period of progres
Externí odkaz:
https://doaj.org/article/74f6fbaa4eec4ff48e00b119eaf2c298
Autor:
Larissa Bartlett, Aidan Bindoff, Kathleen Doherty, Sarang Kim, Claire Eccleston, Alex Kitsos, Eddy Roccati, Jane Alty, Anna E. King, James C. Vickers
Publikováno v:
BMC Public Health, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Unmanaged cardiometabolic health, low physical and cognitive activity, poor diet, obesity, smoking and excessive alcohol consumption are modifiable health risk factors for dementia and public health approaches to dementia preventi
Externí odkaz:
https://doaj.org/article/1abc3ba7f82b4904a415b6a95c811303
Autor:
Eddy Roccati, Aidan David Bindoff, Jessica Marie Collins, Joshua Eastgate, Jay Borchard, Jane Alty, Anna Elizabeth King, James Clement Vickers, Margherita Carboni, Chad Logan, EPAD Consortium
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionModifiable risk factors account for a substantial proportion of Alzheimer’s disease (AD) cases and we currently have a discrete AT(N) biomarker profile for AD biomarkers: amyloid (A), p-tau (T), and neurodegeneration (N). Here, we inves
Externí odkaz:
https://doaj.org/article/68752c2a77b6442a8a18d64d9d78b8b8
Autor:
Renjie Li, Xinyi Wang, Katherine Lawler, Saurabh Garg, Rebecca J. St George, Aidan D. Bindoff, Larissa Bartlett, Eddy Roccati, Anna E. King, James C. Vickers, Quan Bai, Jane Alty
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Low‐cost simple tests for preclinical Alzheimer's disease are a research priority. We evaluated whether remote unsupervised webcam recordings of finger‐tapping were associated with cognitive performance in older adults. METH
Externí odkaz:
https://doaj.org/article/8185901f45864982a6c627cf05eef2af
Does serum neurofilament light help predict accelerated cognitive ageing in unimpaired older adults?
Autor:
Jessica M. Collins, Aidan D. Bindoff, Eddy Roccati, Jane E. Alty, James C. Vickers, Anna E. King
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionNeurofilament light (NfL) is a blood biomarker of neurodegeneration. While serum NfL levels have been demonstrated to increase with normal ageing, the relationship between serum NfL levels and normal age-related changes in cognitive funct
Externí odkaz:
https://doaj.org/article/23b3e954c4794582b21d8c76f84a5a5e
Autor:
Jane Alty, Quan Bai, Renjie Li, Katherine Lawler, Rebecca J. St George, Edward Hill, Aidan Bindoff, Saurabh Garg, Xinyi Wang, Guan Huang, Kaining Zhang, Kaylee D. Rudd, Larissa Bartlett, Lynette R. Goldberg, Jessica M. Collins, Mark R. Hinder, Sharon L. Naismith, David C. Hogg, Anna E. King, James C. Vickers
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background The worldwide prevalence of dementia is rapidly rising. Alzheimer’s disease (AD), accounts for 70% of cases and has a 10–20-year preclinical period, when brain pathology covertly progresses before cognitive symptoms appear. Th
Externí odkaz:
https://doaj.org/article/480ea2a8937f452e859aaf3451cc9168
Autor:
Sueanne Chear, Sharn Perry, Richard Wilson, Aidan Bindoff, Jana Talbot, Tyson L. Ware, Alexandra Grubman, James C. Vickers, Alice Pébay, Jonathan B. Ruddle, Anna E. King, Alex W. Hewitt, Anthony L. Cook
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/8506b6697e2647a08022c28a7bd9530c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Resting-state functional magnetic resonance imaging measures pathological alterations in neurodegenerative diseases, including Alzheimer’s disease. Disruption in functional connectivity may be a potential biomarker of ageing and early brai
Externí odkaz:
https://doaj.org/article/f8bf9247b60f414dba08098878c71068
Autor:
Drew Neavin, Quan Nguyen, Maciej S. Daniszewski, Helena H. Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, James C. Vickers, Anthony L. Cook, Nathan J. Palpant, Alice Pébay, Alex W. Hewitt, Joseph E. Powell
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies. Gene expression plays
Externí odkaz:
https://doaj.org/article/d89867322e804dd0acd2dc0180fe5fe8
Autor:
Larissa Bartlett, Kathleen Doherty, Maree Farrow, Sarang Kim, Edward Hill, Anna King, Jane Alty, Claire Eccleston, Alex Kitsos, Aidan Bindoff, James C Vickers
Publikováno v:
JMIR Research Protocols, Vol 11, Iss 3, p e34688 (2022)
BackgroundUp to 40% of incident dementia is considered attributable to behavioral and lifestyle factors. Given the current lack of medical treatments and the projected increase in dementia prevalence, a focus on prevention through risk reduction is n
Externí odkaz:
https://doaj.org/article/6bb72697937c438485ead91ba62b52c6