Zobrazeno 1 - 10
of 189
pro vyhledávání: '"James A Timmons"'
Autor:
James A Timmons, Andrew Anighoro, Robert J Brogan, Jack Stahl, Claes Wahlestedt, David Gordon Farquhar, Jake Taylor-King, Claude-Henry Volmar, William E Kraus, Stuart M Phillips
Publikováno v:
eLife, Vol 11 (2022)
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic
Externí odkaz:
https://doaj.org/article/7e19e8df597247648f62daff3c3765f3
Autor:
Bethan E Phillips, John P Williams, Thomas Gustafsson, Claude Bouchard, Tuomo Rankinen, Steen Knudsen, Kenneth Smith, James A Timmons, Philip J Atherton
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003389 (2013)
Physical activity and molecular ageing presumably interact to precipitate musculoskeletal decline in humans with age. Herein, we have delineated molecular networks for these two major components of sarcopenic risk using multiple independent clinical
Externí odkaz:
https://doaj.org/article/59a5371acfcd420087df5365ec4cfde7
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment.
Autor:
Anna-Karin Roos, Fredrik Eriksson, James A Timmons, Josefine Gerhardt, Ulrika Nyman, Lindvi Gudmundsdotter, Andreas Bråve, Britta Wahren, Pavel Pisa
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7226 (2009)
BACKGROUND: Electrical pulses have been used to enhance uptake of molecules into living cells for decades. This technique, often referred to as electroporation, has become an increasingly popular method to enhance in vivo DNA delivery for both gene t
Externí odkaz:
https://doaj.org/article/5a55aaaf40ee4e5fae052130e2f93055
Autor:
Katarina Fredriksson, Inga Tjäder, Pernille Keller, Natasa Petrovic, Bo Ahlman, Camilla Schéele, Jan Wernerman, James A Timmons, Olav Rooyackers
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3686 (2008)
BackgroundSeptic patients treated in the intensive care unit (ICU) often develop multiple organ failure including persistent skeletal muscle dysfunction which results in the patient's protracted recovery process. We have demonstrated that muscle mito
Externí odkaz:
https://doaj.org/article/d84df17e2f054fc189667567154e96de
Autor:
Tanner Stokes, Haoning Howard Cen, Philipp Kapranov, Iain J Gallagher, Andrew A. Pitsillides, Claude‐Henry Volmar, William E Kraus, James D. Johnson, Stuart M. Phillips, Claes Wahlestedt, James A. Timmons
Publikováno v:
Advanced Genetics, Vol 4, Iss 2, Pp n/a-n/a (2023)
Abstract Sequencing the human genome empowers translational medicine, facilitating transcriptome‐wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short‐rea
Externí odkaz:
https://doaj.org/article/e905fbd859144cbe92af1c8b24906620
Publikováno v:
Research Quarterly for Exercise and Sport. :1-9
Autor:
Kenneth C.H. Fearon, James A. Timmons, James A. Ross, Carolyn A. Greig, Holger Husi, Richard J.E. Skipworth, Alisdair J. MacDonald, Nathan A. Stephens, Iain J. Gallagher
XLS file - 240K, Spreadsheet of regulated genes, primers used, geneset enrichment analysis results and meta analysis with other datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a5c3cd2a00329a238a4d7dd49d2de3
https://doi.org/10.1158/1078-0432.22443822.v1
https://doi.org/10.1158/1078-0432.22443822.v1
Autor:
Kenneth C.H. Fearon, James A. Timmons, James A. Ross, Carolyn A. Greig, Holger Husi, Richard J.E. Skipworth, Alisdair J. MacDonald, Nathan A. Stephens, Iain J. Gallagher
Purpose: The mechanisms underlying muscle wasting in patients with cancer remain poorly understood, and consequently there remains an unmet clinical need for new biomarkers and treatment strategies.Experimental Design: Microarrays were used to examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8183a94995ecedde0a5600dcf034b58e
https://doi.org/10.1158/1078-0432.c.6519975
https://doi.org/10.1158/1078-0432.c.6519975
Autor:
Jessica L. Dennison, Claude-Henry Volmar, Farzaneh Modarresi, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Journal of Alzheimer's Disease. 86:173-190
Background: Alzheimer’s disease (AD) has minimally effective treatments currently. High concentrations of resveratrol, a polyphenol antioxidant found in plants, have been reported to affect several AD-related and neuroprotective genes. To address t
Publikováno v:
Aging Clinical and Experimental Research. 34:927-934
BACKGROUND Changes in nutrient intakes and protein distribution were analyzed in response to a whole food-based dietary intervention targeting high-protein meals in older adults. METHODS Community-dwelling older adults (n = 56; M/F, 28/28; age, 69.3