Zobrazeno 1 - 10
of 327
pro vyhledávání: '"James A Timmons"'
Autor:
Tanner Stokes, Haoning Howard Cen, Philipp Kapranov, Iain J Gallagher, Andrew A. Pitsillides, Claude‐Henry Volmar, William E Kraus, James D. Johnson, Stuart M. Phillips, Claes Wahlestedt, James A. Timmons
Publikováno v:
Advanced Genetics, Vol 4, Iss 2, Pp n/a-n/a (2023)
Abstract Sequencing the human genome empowers translational medicine, facilitating transcriptome‐wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short‐rea
Externí odkaz:
https://doaj.org/article/e905fbd859144cbe92af1c8b24906620
Autor:
James A Timmons, Andrew Anighoro, Robert J Brogan, Jack Stahl, Claes Wahlestedt, David Gordon Farquhar, Jake Taylor-King, Claude-Henry Volmar, William E Kraus, Stuart M Phillips
Publikováno v:
eLife, Vol 11 (2022)
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic
Externí odkaz:
https://doaj.org/article/7e19e8df597247648f62daff3c3765f3
Autor:
Huifen Cao, Lorena Salazar-García, Fan Gao, Thor Wahlestedt, Chun-Lin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, DingDing Cai, Huifang Wang, Mario P. S. Chin, James A. Timmons, Claes Wahlestedt, Philipp Kapranov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “
Externí odkaz:
https://doaj.org/article/3feb697ac4a94e7e834ab5f5f7ce2e50
Autor:
James A. Timmons, Iain J. Gallagher, Sanjana Sood, Bethan Phillips, Hannah Crossland, Robert Howard, William E. Kraus, Philip J. Atherton
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-4 (2019)
Abstract Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misundersta
Externí odkaz:
https://doaj.org/article/62128a060b074590976d2841dc214b53
Publikováno v:
Frontiers in Sports and Active Living, Vol 3 (2021)
Most studies in older adults have utilized powdered protein supplements or oral nutrition solutions as a source of additional dietary protein, but whole foods may provide a greater anabolic stimulus than protein isolated from food matrices. Therefore
Externí odkaz:
https://doaj.org/article/7717315a77654fdeb093b0d18b77b6fd
Autor:
Tanner Stokes, James A. Timmons, Hannah Crossland, Thomas R. Tripp, Kevin Murphy, Chris McGlory, Cameron J. Mitchell, Sara Y. Oikawa, Robert W. Morton, Bethan E. Phillips, Steven K. Baker, Phillip J. Atherton, Claes Wahlestedt, Stuart M. Phillips
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107980- (2020)
Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-per
Externí odkaz:
https://doaj.org/article/18dc950e6ad74f6da319809a231bbce1
Publikováno v:
Research Quarterly for Exercise and Sport. :1-9
Autor:
Kenneth C.H. Fearon, James A. Timmons, James A. Ross, Carolyn A. Greig, Holger Husi, Richard J.E. Skipworth, Alisdair J. MacDonald, Nathan A. Stephens, Iain J. Gallagher
XLS file - 240K, Spreadsheet of regulated genes, primers used, geneset enrichment analysis results and meta analysis with other datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a5c3cd2a00329a238a4d7dd49d2de3
https://doi.org/10.1158/1078-0432.22443822.v1
https://doi.org/10.1158/1078-0432.22443822.v1
Autor:
Kenneth C.H. Fearon, James A. Timmons, James A. Ross, Carolyn A. Greig, Holger Husi, Richard J.E. Skipworth, Alisdair J. MacDonald, Nathan A. Stephens, Iain J. Gallagher
Purpose: The mechanisms underlying muscle wasting in patients with cancer remain poorly understood, and consequently there remains an unmet clinical need for new biomarkers and treatment strategies.Experimental Design: Microarrays were used to examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8183a94995ecedde0a5600dcf034b58e
https://doi.org/10.1158/1078-0432.c.6519975
https://doi.org/10.1158/1078-0432.c.6519975
Autor:
Jessica L. Dennison, Claude-Henry Volmar, Farzaneh Modarresi, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Publikováno v:
Journal of Alzheimer's Disease. 86:173-190
Background: Alzheimer’s disease (AD) has minimally effective treatments currently. High concentrations of resveratrol, a polyphenol antioxidant found in plants, have been reported to affect several AD-related and neuroprotective genes. To address t