Zobrazeno 1 - 10
of 2 256
pro vyhledávání: '"James A Stewart"'
Autor:
Ahmed Mostafa, Mahmoud M. Naguib, Aitor Nogales, Ramya S. Barre, James P. Stewart, Adolfo García-Sastre, Luis Martinez-Sobrido
Publikováno v:
mBio, Vol 15, Iss 12 (2024)
ABSTRACT Since the emergence of highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.3.4.4b as a novel reassortant virus from subtype H5N8, the virus has led to a massive number of outbreaks worldwide in wild and domestic birds. Compared t
Externí odkaz:
https://doaj.org/article/07821d9b24854c9ba114807c940d4a49
Autor:
Arpita Deb, Brian D. Tow, Jie Hao, Branden L. Nguyen, Valeria Gomez, James A. Stewart, Jr, Ashley J. Smuder, Bjorn C. Knollmann, Ying Wang, Bin Liu
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100093- (2024)
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca2+) release channel ryanodine receptor (RyR2) and its accessory proteins. These mutations make the channel
Externí odkaz:
https://doaj.org/article/0d1bf4464fc44ee5952fe594a9b9b7b8
Autor:
Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chang
Publikováno v:
PLoS Biology, Vol 22, Iss 11, p e3002843 (2024)
The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. While both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems mainta
Externí odkaz:
https://doaj.org/article/46e7cfe50f764c2d96152c223285331c
Autor:
Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Kukatharmini Tharmaratnam, Edward J. Needham, Robyn Williams, Yun Huang, Greta K. Wood, Ceryce Collie, Andrew Fower, Hannah Fox, Mark A. Ellul, Marie Held, Franklyn N. Egbe, Michael Griffiths, Tom Solomon, Gerome Breen, Anja Kipar, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, James P. Stewart, Leonie S. Taams, David K. Menon, Benedict D. Michael
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K18-hACE2 mo
Externí odkaz:
https://doaj.org/article/b407a024b99e4716aa954f209f08e65d
Autor:
Pol Grootswagers, Daimy Bach, Ynte Biemans, Pariya Behrouzi, Steve Horvath, Charlotte S. Kramer, Simin Liu, JoAnn E. Manson, Aladdin H. Shadyab, James D. Stewart, Eric Whitsel, Bo Yang, Lisette de Groot
Publikováno v:
The Journal of Nutrition, Health and Aging, Vol 28, Iss 9, Pp 100324- (2024)
Background: Along with the ageing of society, the absolute prevalence of age-related diseases is expected to rise, leading to a substantial burden on healthcare systems and society. Thus, there is an urgent need to promote healthy ageing. As opposed
Externí odkaz:
https://doaj.org/article/f7df9949402b4ef0abb0f9017c58297b
Autor:
Lee Tatham, Anja Kipar, Jo Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith Kumar Reddy Rajoli, Steve Rannard, James P. Stewart, Andrew Owen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT With some exceptions, global policymakers have recommended against the use of existing monoclonal antibodies in COVID-19 due to loss of neutralization of newer variants. The purpose of this study was to investigate the impact of Ronapreve on
Externí odkaz:
https://doaj.org/article/f7da676fb57b4ce9b203c40c216624a1
Autor:
James W. Stewart, II, MD, MSc, Donald Nieter, MHSA, DVM, CCP-Emeritus, Xiaoting Wu, PhD, Alphonse DeLucia, III, MD, Brittney N. Graebner, CCP, Gaetano Paone, MD, MHSA, David C. Fitzgerald, DHA, MPH, CCP, Timothy A. Dickinson, MS, CCP, Min Zhang, PhD, Francis D. Pagani, MD, PhD, Donald S. Likosky, PhD
Publikováno v:
JTCVS Open, Vol 17, Iss , Pp 121-144 (2024)
Objective: Professional standards recommend stopping cardiotomy suction at the termination of cardiopulmonary bypass before protamine administration based on perceived safety concerns. This study evaluated a multidisciplinary collaborative quality-im
Externí odkaz:
https://doaj.org/article/75b399a4555e456ebb23546cbe734bf9
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72080 (2013)
Cardiovascular complications are a leading cause of death in patients with type 2 diabetes mellitus (T2DM). Diastolic dysfunction is one of the earliest manifestations of diabetes-induced changes in left ventricular (LV) function, and results from a
Externí odkaz:
https://doaj.org/article/8f26effd8dcc47ef809da325212a2a03
Publikováno v:
Viruses, Vol 16, Iss 11, p 1730 (2024)
Bovine gammaherpesvirus 6 (BoHV-6) is endemic in cattle in Europe, with a high prevalence. There is evidence that the virus is a commensal and not associated with disease processes. For other gammaherpesviruses, it is known that they have a rather sp
Externí odkaz:
https://doaj.org/article/fdfd423edf824d4d9c670bf6aae256cf
Autor:
Flavia M Souza-Smith, Paige S Katz, Aaron J Trask, James A Stewart, Kevin C Lord, Kurt J Varner, Dalton V Vassallo, Pamela A Lucchesi
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23337 (2011)
Resistance vessel remodeling is controlled by myriad of hemodynamic and neurohormonal factors. This study characterized structural and molecular remodeling in mesenteric resistance arteries (MRAs) in diabetic (db/db) and control (Db/db) mice.Structur
Externí odkaz:
https://doaj.org/article/327f705fce144702b8555b3c04ed2c40