Zobrazeno 1 - 10
of 120
pro vyhledávání: '"James A Nathan"'
Autor:
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001959 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/b29561a147434b44ba62633c5cedb4fe
Autor:
Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Bertini, Michael P Murphy, James A Nathan, Carlo Viscomi, Erika Fernandez‐Vizarra, Massimo Zeviani
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-21 (2018)
Abstract Loss‐of‐function mutations in APOPT1, a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome c oxidase (COX) deficiency. Although the genetic
Externí odkaz:
https://doaj.org/article/215a8a7301c4477ba2ac4a4276753ce7
Autor:
Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Publikováno v:
eLife, Vol 7 (2018)
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions,
Externí odkaz:
https://doaj.org/article/f84da21acd8c46149f6d640a9199b032
Publikováno v:
eLife, Vol 6 (2017)
Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation. Observations that HIF
Externí odkaz:
https://doaj.org/article/17b5963dc2be4395a5d3592f77ec8cf3
Autor:
Carsten C Scholz, Javier Rodriguez, Christina Pickel, Stephen Burr, Jacqueline-Alba Fabrizio, Karen A Nolan, Patrick Spielmann, Miguel A S Cavadas, Bianca Crifo, Doug N Halligan, James A Nathan, Daniel J Peet, Roland H Wenger, Alex Von Kriegsheim, Eoin P Cummins, Cormac T Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002347 (2016)
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a g
Externí odkaz:
https://doaj.org/article/195eb6b4e4534a8d981fea77cbdb36dd
Autor:
Brunetti, Irene1,2 (AUTHOR), James Pataki, Nathan3,4 (AUTHOR), Hinojosa, Diego R.5 (AUTHOR), Hawkey, Angus6 (AUTHOR), Karakaya, Ozan1,2 (AUTHOR), Rainer, Christian1,2 (AUTHOR), Khan, Muhammad Irfan1 (AUTHOR), Franke, Leonard1 (AUTHOR), Mallick, Md Mofasser1 (AUTHOR), Hernandez‐Sosa, Gerardo1,2,7 (AUTHOR), Kemerink, Martijn8 (AUTHOR), Caironi, Mario3 (AUTHOR), Lemmer, Uli1,2,7 (AUTHOR) uli.lemmer@kit.edu
Publikováno v:
Advanced Materials Technologies. Oct2024, p1. 10p. 6 Illustrations, 1 Chart.
Autor:
Kobernick, Aaron K., Mohammad, Acklema, Cherry, Adam T., Fein, Alan, Gaines, Alan, Allison Ramsey, Michaud, Amanda L., Palmer, Amy, Kim, Andrew S., Smith, Andrew M., White, Andrew A., Ricci, Anthony R., Kettelhut, Brett V., Modena, Brian D., Stone, Brian, Rolston, B. Steele, Schnapf, Bruce M., Krajicek, Bryan, Kraft, Cara, Hopkins, Carly, Natalie, Chitra R., Anderson, Christine, Czajkowski, Christine, Arce, Daisy, Hamlin, Danuel, Hill, David G., Mares, David C., Pham, David, Liao, Da-Wei, Simmons, Deborah, Johnson, Derek K., Jhaveri, Devi K., Maselli, Diego J., Kerwin, Edward, Schuman, Edward, Sher, Ellen R., Bleecker, Eugene, Rakowski, Ewa, Ida Hsu, Florence, Averill, Francis J., Barsanti, Franco, Gross, Gary N., Chupp, Geoffrey Lowell, Head, G. Gilbert, Nasir, Hassan, Lee, Howard J., Barjaktarevic, Igor, Cook, J. Paul, Krainson, James P., Pearl, James E., Bellak, Jason M., Perez-Fernandez, Javier, Rehm, Jeffrey, Trevor, Jennifer, Freyer Most, Jessica, Hanson, Jill, Blessing-Moore, Joann, Biller, Jodi H., Gedell, John, Southard, John G., Chancellor, Jon Eric, Ilowite, Jonathan, Romeo, Jonathan R., Manuel Mercado, Jorge, Dominic Fisher, Joseph, Greiwe, Justin, Gregory, Karen L., Nadeau, Kari, Shenoy, Kartik V., Tan, Laren D., Stefanowicz, Leslie A., Humes, Lindsay D., Bowers, Lori A., Edel O’Connor, Maeve, Perez, Mario F., White, Martha V., Hegewald, Matthew, Wilson, Matthew C., Sikora, Maxcie M., Lee Morganroth, Melvin, Smith, Mitchell, Farooqui, Nabeel, James Lesch, Nathan, Jain, Neal, Parikh, Neil, Hartog, Nicholas L., Luthin, Patricia L., Stewart, Patricia H., Rubio O’Connor, Peggy, Schochet, Peter, Goldberg, Pinkus, Patel, Pulin P., Chinthrajah, R. Sharon, Sidhu, Rabinder, Ayinla, Raji M., Brown, Randall, Stadtler, Reneé, Wachs, Richard A., Balkissoon, Ronald C., Duplantier, Rory L., Puente, Rosalba E., Settipane, Russell, Mustafa, S. Shahzad, Surani, Salim, Abdul Jawad, Sami, Adams, Sandra G., Villegas, Sarah, Al-Farra, Sherif, Subramanian, Shyamsunder, Bains, Sonia N., Kelsen, Steven G., Wise, Steven L., Estrella-Eades, Susan, Smith, Susan M., Qureshi, Tabarak, Chen, Taiwen, Kelbel, Theodore E., Miller, Thomas P., Jain, Vipin, Soong, Weily, Soler, Xavier, Mattar, Ziad R., Murphy, Kevin R., Chipps, Bradley, Beuther, David A., Wise, Robert A., McCann, William, Gilbert, Ileen, Eudicone, James M., Gandhi, Hitesh N., Harding, Gale, Coyne, Karin S., Zeiger, Robert S.
Publikováno v:
In The Journal of Allergy and Clinical Immunology: In Practice July-August 2020 8(7):2263-2274
Autor:
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M. Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C. James, Katarzyna A. Ciazynska, Xiaoli Xiong, John A.G. Briggs, James A. Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A. Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth G.C. Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K. Gupta, Stephen Baker, Gordon Dougan, Ravi Gupta, Paul J. Lehner, Paul Lyons, Nicholas J. Matheson, Mark Toshner, Michael P. Weekes, Nick Brown, Martin Curran, Surendra Palmar, David Enoch, Daniel Chapman, Ashley Shaw, Sherly Jose, Areti Bermperi, Julie Ann Zerrudo, Evgenia Kourampa, Laura Watson, Jieniean Worsley, Caroline Saunders, Ranalie de Jesus, Jason Domingo, Ciro Pasquale, Bensi Vergese, Phoebe Vargas, Marivic Fabiculana, Marlyn Perales, Lee Mynott, Elizabeth Blake, Amy Bates, Anne-Laure Vallier, Alexandra Williams, David Phillips, Edmund Chiu, Alex Overhill, Nicola Ramenatte, Jamal Sipple, Steven Frost, Helena Knock, Richard Hardy, Emily Foster, Fiona Davidson, Viona Rundell, Purity Bundi, Richmond Abeseabe, Sarah Clark, Isabel Vicente, Anne Elmer, Carla Ribeiro, Jenny Kourampa, Jane Kennet, Jane Rowlands, Anne Meadows, Criona O’Brien, Rebecca Rastall, Cherry Crucusio, Sarah Hewitt, Jane Price, Jo Calder, Laura Canna, Ashlea Bucke, Hugo Tordesillas, Julie Harris, Valentina Ruffolo, Barbara Graves, Helen Butcher, Daniela Caputo, Emma Le Gresley, Benjamin J. Dunmore, Jennifer Martin, Ekaterina Legchenko, Carmen Treacy, Christopher Huang, Jennifer Wood, Rachel Sutcliffe, Josh Hodgson, Joy Shih, Stefan Graf, Zhen Tong, Tobias Tilly, Ciara O’Donnell, Kelvin Hunter, Linda Pointon, Nicole Pond, Marta Wylot, Emma Jones, Stuart Fawke, Ben Bullman, Lori Turner, Isobel Jarvis, Ommar Omarjee, Aloka De Sa, Joe Marsden, Ariana Betancourt, Marianne Perera, Maddie Epping, Nathan Richoz, Georgie Bower, Rahul Sharma, Francesca Nice, Oisin Huhn, Natalia Savoinykh Yarkoni, Nika Romashova, Daniel Lewis, Andrew Hinch, Chiara Cossetti, Mateusz Strezlecki, Richard Grenfell, Hannah Stark, Neil Walker, Kathy Stirrups, Nigel Ovington, Eleanor Dewhust, Emily Li, Sofia Papadia, Nathalie Kingston, Andrew Lever, Estee Torok, William Hamilton, Grant Hall, Aminu Jahun, Yasmin Chaudhry, Malte Pinckert, Iliana Georgana, Anna Yakovleva, Laura Caller, Sarah Caddy, Theresa Feltwell, Fahad Khokhar, Luke Meredith, Charlotte Holdcroft, Surendra Parmar
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 6, Pp 100099- (2020)
Summary: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant dominates the p
Externí odkaz:
https://doaj.org/article/f56b9ae7c1d24d12996d40bd0463ae07
Autor:
Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are
Externí odkaz:
https://doaj.org/article/2e185917117c4d43933d36f98b9d58b0
Autor:
Anthony W. Martinelli, William Dunn, Mark E. McClure, Ieuan Walker, Andrew Stewart, Sumit Karia, Stephen D. Preston, Sathia Thiru, Nicholas Torpey, Sanjay Ojha, Emily Symington, James A. Nathan
Publikováno v:
Chest. 162:e245-e248
Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e77f0d99c71dc70bc49a33b5a6172f
https://doi.org/10.1016/j.chest.2022.06.023
https://doi.org/10.1016/j.chest.2022.06.023