Zobrazeno 1 - 10
of 1 034
pro vyhledávání: '"James A Morgan"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract A compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a substrate in major cell functions including mitochondrial homeostasis, cell signalling, ax
Externí odkaz:
https://doaj.org/article/c62d4651bc754691a932e223690ee151
Autor:
Robert A Harper, David P Crabb, Augusto Azuara-Blanco, James E Morgan, Yemisi Takwoingi, Gus Gazzard, Rodolfo Hernández, Verity Watson, Anthony King, Hangjian Wu
Publikováno v:
BMJ Open Ophthalmology, Vol 9, Iss 1 (2024)
Background/aims To elicit the preferences and calculate the willingness to pay (WTP) of patients with ocular hypertension (OHT) for eye monitoring services in the UK.Methods Patients with OHT aged at least 18 years recruited from four NHS ophthalmolo
Externí odkaz:
https://doaj.org/article/ca1d6571bef448228e11ff93ff01a089
Autor:
Myungjin Kim, Jun Yong Kim, Won-Kyu Rhim, Gloria Cimaglia, Andrew Want, James E. Morgan, Pete A. Williams, Chun Gwon Park, Dong Keun Han, Seungsoo Rho
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine dinucleotide (NAD) is a cofacto
Externí odkaz:
https://doaj.org/article/26e41b9264f445c88f07e8d5e2066399
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract This study is about the quantification and validation of BDNF levels in mouse serum and plasma using a sensitive immunoassay. While BDNF levels are readily detectable in human serum, the functional implications of these measurements are uncl
Externí odkaz:
https://doaj.org/article/c897cde093af4796bc64842dc19456ea
Autor:
Thomas S. Webberley, Giulia Masetti, Ryan J. Bevan, Joshua Kerry-Smith, Alison A. Jack, Daryn R. Michael, Sophie Thomas, Maria Glymenaki, Jia Li, Julie A. K. McDonald, Daniel John, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Timothy R. Hughes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Brain degenerative disorders such as Alzheimer’s disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising preventative strategy for both neurodegeneration and metabolic syndrome. In
Externí odkaz:
https://doaj.org/article/77eda7a758794348b5e35fc83931f5f5
Autor:
Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk l
Externí odkaz:
https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a2
Autor:
Thomas S. Webberley, Ryan J. Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R. Michael, Sophie Thomas, Meg Rees, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Duolao Wang, Timothy R. Hughes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4683 (2023)
Aging and metabolic syndrome are associated with neurodegenerative pathologies including Alzheimer’s disease (AD) and there is growing interest in the prophylactic potential of probiotic bacteria in this area. In this study, we assessed the neuropr
Externí odkaz:
https://doaj.org/article/e72309a117a74e4c84fcf9c17609b021
Autor:
Ryan J. Bevan, Tim R. Hughes, Pete A. Williams, Mark A. Good, B. Paul Morgan, James E. Morgan
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Neuronal dendritic and synaptic pruning are early features of neurodegenerative diseases, including Alzheimer’s disease. In addition to brain pathology, amyloid plaque deposition, microglial activation, and cell loss occur in the retinas o
Externí odkaz:
https://doaj.org/article/61a61e0eabc6470bbf42d6cef97e7105
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010144 (2022)
Polyglutamylation is a dynamic posttranslational modification where glutamate residues are added to substrate proteins by 8 tubulin tyrosine ligase-like (TTLL) family members (writers) and removed by the 6 member Nna1/CCP family of carboxypeptidases
Externí odkaz:
https://doaj.org/article/f5abf2339ac246559ff6afb3fd4b31d9
Autor:
Deepak N. Subramanian, Magnus Zethoven, Simone McInerny, James A. Morgan, Simone M. Rowley, Jue Er Amanda Lee, Na Li, Kylie L. Gorringe, Paul A. James, Ian G. Campbell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Around half of the heritability underpinning familial high-grade serous ovarian carcinoma remains unidentified. Here, the authors show that extremely rare protein encoding loss-of-function variants, with a high degree of genetic heterogeneity, may ac
Externí odkaz:
https://doaj.org/article/a521a39eb0dc4d439f6807027b6fe81f