Zobrazeno 1 - 10
of 295
pro vyhledávání: '"James A Holden"'
Autor:
Tamara Matthyssen, Wenyi Li, James A. Holden, Jason C. Lenzo, Sara Hadjigol, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionMelittin is a potent antimicrobial peptide from bee venom that is effective against both Gram-positive and Gram-negative bacteria. However, it is extremely toxic to mammalian cells and, as yet, has no clinical use. Modifications to its am
Externí odkaz:
https://doaj.org/article/81af5452720b48978a8b1731c22bac4e
Autor:
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151967 (2016)
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were produced using tangential flow ultrafiltration, ultracentrifugation and Optiprep density gradient
Externí odkaz:
https://doaj.org/article/dca2c5983f8449e5853555e93e330330
Autor:
Roselind S Lam, Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Shao B Fong, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158629 (2016)
Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Tissue macrophages are amongst the first immune cells to respond to bacteria and depending on the cytokine profile at the infection site, macrophages are pri
Externí odkaz:
https://doaj.org/article/d720ce551abc4d8285e85e1500415c11
Autor:
Elizabeth C. Sklute, Deborah A. Leopo, Kaylee A. Neat, Kenneth J. T. Livi, M. Darby Dyar, James F. Holden
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Some thermophilic bacteria from deep-sea hydrothermal vents grow by dissimilatory iron reduction, but our understanding of their biogenic mineral transformations is nascent. Mineral transformations catalyzed by the thermophilic iron-reducing bacteriu
Externí odkaz:
https://doaj.org/article/31d5a77346d54f7785de22d1e58e06b1
Autor:
James F. Holden, Harita Sistu
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Extremely thermophilic methanogens in the Methanococci and heterotrophs in the Thermococci are common in deep-sea hydrothermal vents. All Methanococci use H2 as an electron donor, and a few species can also use formate. Most Methanococci have a coenz
Externí odkaz:
https://doaj.org/article/95c3ca28b55b4f72a02013864017f254
Autor:
Tamara Matthyssen, Wenyi Li, James A. Holden, Jason C. Lenzo, Sara Hadjigol, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum antibacterial activity, and can modulate the immune system. Furthermore, they have a very low level of resistance induction in bacteria, which makes them an i
Externí odkaz:
https://doaj.org/article/98c85387bb9f4cb68bf6fe09697584e8
Autor:
Tetiana Hourani, James A. Holden, Wenyi Li, Jason C. Lenzo, Sara Hadjigol, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis, with various components being involved in tumor suppression and tumor growth. A protumorigenic TME is characterized by an increased infiltration of tumor associate
Externí odkaz:
https://doaj.org/article/b2e0f839ce7e460ba22553c1c9c19f26
Autor:
Zhe Sun, Wenyi Li, Jason C. Lenzo, James A. Holden, Michael J. McCullough, Andrea J. O’Connor, Neil M. O’Brien-Simpson
Publikováno v:
Frontiers in Materials, Vol 8 (2021)
Vaccination is one of the most efficacious and cost-effective ways to protect people from infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole pathogens to subunit antigens has brought attention on to vaccine d
Externí odkaz:
https://doaj.org/article/675347a3de3d405b96208e064eaa4320
Autor:
David A. Clague, Julie F. Martin, Jennifer B. Paduan, David A. Butterfield, John W. Jamieson, Morgane Le Saout, David W. Caress, Hans Thomas, James F. Holden, Deborah S. Kelley
Publikováno v:
Geochemistry, Geophysics, Geosystems, Vol 21, Iss 6, Pp n/a-n/a (2020)
Abstract The Endeavour Segment of the Juan de Fuca Ridge is well known for its abundance of hydrothermal vents and chimneys. One‐meter scale multibeam mapping data collected by an autonomous undersea vehicle revealed 572 chimneys along the central
Externí odkaz:
https://doaj.org/article/9410603897b6409094865a350b917b8a
Autor:
Brian J. Vaccaro, Sonya M. Clarkson, James F. Holden, Dong-Woo Lee, Chang-Hao Wu, Farris L. Poole II, Julien J. H. Cotelesage, Mark J. Hackett, Sahel Mohebbi, Jingchuan Sun, Huilin Li, Michael K. Johnson, Graham N. George, Michael W. W. Adams
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The biosynthesis of iron-sulfur clusters in anaerobic organisms has not been extensively investigated. Here, the authors identify and characterize a multi-subunit protein that stores iron and sulfur in thioferrate for the assembly of the clusters inP
Externí odkaz:
https://doaj.org/article/e2eb24a5a30a40d99e8abcc299c93b4a