Zobrazeno 1 - 10
of 948
pro vyhledávání: '"James A Fraser"'
Autor:
Holly E. E. Floyd, Angela M. Kavanagh, Gabrielle J. Lowe, Maite Amado, James A. Fraser, Mark A. T. Blaskovich, Alysha G. Elliott, Johannes Zuegg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The Clinical and Laboratory Standards Institute (CLSI) M27 guidelines are the recommended and most commonly used protocols for broth microdilution antifungal susceptibility testing of yeasts. However, these guidelines are limited to the use
Externí odkaz:
https://doaj.org/article/5715a4a68f274e159835ad33865e4149
Autor:
Benjamin Hommel, Liliane Mukaremera, Radames J B Cordero, Carolina Coelho, Christopher A Desjardins, Aude Sturny-Leclère, Guilhem Janbon, John R Perfect, James A Fraser, Arturo Casadevall, Christina A Cuomo, Françoise Dromer, Kirsten Nielsen, Alexandre Alanio
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1006982 (2018)
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditio
Externí odkaz:
https://doaj.org/article/9d2418cfc3ce423aa25c52e69c2945ef
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171443 (2017)
Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid biosynthesis, a pathway essential to the life-cycle of plants and micro-organisms. The catalytic subunit has thiamin diphosphate (ThDP) and flavin adenine dinucleo
Externí odkaz:
https://doaj.org/article/8461101fa8174e05a8fe860c0e127821
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 494-501 (2024)
In the folded state, biomolecules exchange between multiple conformational states crucial for their function. However, most structural models derived from experiments and computational predictions only encode a single state. To represent biomolecules
Externí odkaz:
https://doaj.org/article/0b2b761acf384d09b28475fb4cdafe9d
Autor:
Christy N. Wails, Claire C. Helmke, Kathleen M. Black, Roger Ramirez-Barrios, Sarah M. Karpanty, Daniel H. Catlin, James D. Fraser
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background Sarcoptic mange is a skin disease caused by the contagious ectoparasite Sarcoptes scabiei, capable of suppressing and extirpating wild canid populations. Starting in 2015, we observed a multi-year epizootic of sarcoptic mange affe
Externí odkaz:
https://doaj.org/article/b331372aa8854794927b941dec4283ae
Autor:
Jingyou Rao, Ruiqi Xin, Christian Macdonald, Matthew K. Howard, Gabriella O. Estevam, Sook Wah Yee, Mingsen Wang, James S. Fraser, Willow Coyote-Maestas, Harold Pimentel
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Deep mutational scanning (DMS) measures the effects of thousands of genetic variants in a protein simultaneously. The small sample size renders classical statistical methods ineffective. For example, p-values cannot be correctly calibrated w
Externí odkaz:
https://doaj.org/article/f2997b4bc0bd45f1b3bfee9e093dce6c
Autor:
Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphory
Externí odkaz:
https://doaj.org/article/b6001b942b874658867de1b8cb4e8907
Autor:
Samantha D M Arras, James A Fraser
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163049 (2016)
The development of a biolistic transformation protocol for Cryptococcus neoformans over 25 years ago ushered in a new era of molecular characterization of virulence in this previously intractable fungal pathogen. However, due to the low rate of homol
Externí odkaz:
https://doaj.org/article/575a4967d59f48279dca967e2b83b5b4
Autor:
Samantha D M Arras, Sheena M H Chua, Maha S I Wizrah, Joshua A Faint, Amy S Yap, James A Fraser
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164322 (2016)
Low rates of homologous integration have hindered molecular genetic studies in Cryptococcus neoformans over the past 20 years, and new tools that facilitate genome manipulation in this important pathogen are greatly needed. To this end, we have inves
Externí odkaz:
https://doaj.org/article/4a63f87cb43647b599fcd0a701722abd
Autor:
Lucas M Taniguti, Patricia D C Schaker, Juliana Benevenuto, Leila P Peters, Giselle Carvalho, Alessandra Palhares, Maria C Quecine, Filipe R S Nunes, Maria C P Kmit, Alvan Wai, Georg Hausner, Karen S Aitken, Paul J Berkman, James A Fraser, Paula M Moolhuijzen, Luiz L Coutinho, Silvana Creste, Maria L C Vieira, João P Kitajima, Claudia B Monteiro-Vitorello
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129318 (2015)
Sporisorium scitamineum is a biotrophic fungus responsible for the sugarcane smut, a worldwide spread disease. This study provides the complete sequence of individual chromosomes of S. scitamineum from telomere to telomere achieved by a combination o
Externí odkaz:
https://doaj.org/article/94014a24115f4d4c831cfeda7df0f783