Zobrazeno 1 - 10
of 60
pro vyhledávání: '"James A Ernst"'
Autor:
Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz:
https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
Autor:
Hok Seon Kim, James A Ernst, Cecilia Brown, Jenny Bostrom, Germaine Fuh, Chingwei V Lee, Arthur Huang, Richard L Vandlen, Daniel G Yansura
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35844 (2012)
Attempts to express eukaryotic multi-spanning membrane proteins at high-levels have been generally unsuccessful. In order to investigate the cause of this limitation and gain insight into the rate limiting processes involved, we have analyzed the eff
Externí odkaz:
https://doaj.org/article/40745774ad584741842837f96d8a8ac0
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2186 (2008)
Although Wnt signaling has been shown to be important for embryonic morphogenesis and cancer pathogenesis of several tissues, its role in prostatic development and tumorigenesis is not well understood. Here we show that Wnt signaling regulated prosta
Externí odkaz:
https://doaj.org/article/c2b46ed2fc8d46ba9399cc5abcfac684
Autor:
William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji, Jasvinder K. Atwal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglobulin G4 monoclon
Externí odkaz:
https://doaj.org/article/bd282779d343414aa689f312c255a80f
Autor:
Bonnee Rubinfeld, Paul Polakis, Hartmut Koeppen, James A. Ernst, Li Miao, Venita I. DeAlmeida
Supplementary Data from The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cba0812147224192659cb83544277d
https://doi.org/10.1158/0008-5472.22367282
https://doi.org/10.1158/0008-5472.22367282
Autor:
Bonnee Rubinfeld, Paul Polakis, Hartmut Koeppen, James A. Ernst, Li Miao, Venita I. DeAlmeida
Wnt signaling is important for normal cell proliferation and differentiation, and mutations in pathway components are associated with human cancers. Recent studies suggest that altered wnt ligand/receptor interactions might also contribute to human t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b75812bb6a52287564a23df499d76f9
https://doi.org/10.1158/0008-5472.c.6495494.v1
https://doi.org/10.1158/0008-5472.c.6495494.v1
Autor:
Ganesh Kolumam, Mark Z. Chen, Raymond Tong, Jose Zavala-Solorio, Lance Kates, Nicholas van Bruggen, Jed Ross, Shelby K. Wyatt, Vineela D. Gandham, Richard A.D. Carano, Diana Ronai Dunshee, Ai-Luen Wu, Benjamin Haley, Keith Anderson, Søren Warming, Xin Y. Rairdan, Nicholas Lewin-Koh, Yingnan Zhang, Johnny Gutierrez, Amos Baruch, Thomas R. Gelzleichter, Dale Stevens, Sharmila Rajan, Travis W. Bainbridge, Jean-Michel Vernes, Y. Gloria Meng, James Ziai, Robert H. Soriano, Matthew J. Brauer, Yongmei Chen, Scott Stawicki, Hok Seon Kim, Laëtitia Comps-Agrar, Elizabeth Luis, Christoph Spiess, Yan Wu, James A. Ernst, Owen P. McGuinness, Andrew S. Peterson, Junichiro Sonoda
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 730-743 (2015)
Dissipating excess calories as heat through therapeutic stimulation of brown adipose tissues (BAT) has been proposed as a potential treatment for obesity-linked disorders. Here, we describe the generation of a humanized effector-less bispecific antib
Externí odkaz:
https://doaj.org/article/acbf9281cbc1473db78d9eaceadaf5d7
Autor:
Matthew A. Dragovich, Viralkumar Davra, Matthew S. Faber, Yoon Kyung Kim, Alex Nisthal, Veronica G. Zeng, Jonathan Jacinto, Juan E. Diaz, Thuy Truong, Jing Qi, Kendra N. Avery, Rumana Rashid, Sung-Hyung Lee, Seung Y. Chu, Christine Bonzon, Ruschelle Love, Matthew J. Bernett, James A. Ernst, Rena Bahjat, Norman J. Barlow, John R. Desjarlais, Michael Hedvat, Gregory L. Moore
Publikováno v:
Cancer Research. 83:2983-2983
T cells in the tumor micro-environment require TCR/MHC engagement and co-stimulatory receptor engagement to achieve optimal activation. Solid tumor cells lack expression of CD28 ligands, so we hypothesized that activation of CD28 signaling at the T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43bd9a9426cbc7ff5f24bbbfc11dd3d
https://doi.org/10.1158/1538-7445.am2023-2983
https://doi.org/10.1158/1538-7445.am2023-2983