Zobrazeno 1 - 10
of 85
pro vyhledávání: '"James A Duce"'
Autor:
Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184104 (2017)
Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA) from dietary vitamin B5, but the neuropathological mechanism and reasons for iron accumulation remain unknown. In this
Externí odkaz:
https://doaj.org/article/f5f6c31baff54e20bd2c981bf542ab13
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114174 (2014)
Ceruloplasmin is a ferroxidase that interacts with ferroportin to export cellular iron, but is not expressed in neurons. We recently reported that the amyloid precursor protein (APP) is the analogous iron-exporting chaperone for neurons and other cel
Externí odkaz:
https://doaj.org/article/560c10145496440f93d643670cc5a4eb
Autor:
Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77023 (2013)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-encoding CAG expansion in the huntingtin gene. Iron accumulates in the brains of HD patients and mouse disease models. However, the cellular and subcellul
Externí odkaz:
https://doaj.org/article/65ddefe2e67e47bbae30df0469525f4e
Autor:
Hind Bouchaoui, Laura Mahoney-Sanchez, Guillaume Garçon, Olivier Berdeaux, Laurent Y. Alleman, David Devos, James A. Duce, Jean-Christophe Devedjian
Publikováno v:
Free Radical Biology and Medicine
Free Radical Biology and Medicine, 2023, 195, pp.145-157. ⟨10.1016/j.freeradbiomed.2022.12.086⟩
Free Radical Biology and Medicine, 2023, 195, pp.145-157. ⟨10.1016/j.freeradbiomed.2022.12.086⟩
International audience; Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels, has been implicated in several neurodegenerative diseases, including Parkinson's disease (PD). Brain regions such as the striatum are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1f09be69c8027a971a32af0aec4e7f
https://pubmed.ncbi.nlm.nih.gov/36581060
https://pubmed.ncbi.nlm.nih.gov/36581060
Autor:
Laura Mahoney-Sanchez, Hind Bouchaoui, Ibrahim Boussaad, Aurélie Jonneaux, Kelly Timmerman, Olivier Berdeaux, Scott Ayton, Rejko Krüger, James A. Duce, David Devos, Jean-Christophe Devedjian
Publikováno v:
Cell Reports
Cell Reports, 2022, 40 (8), pp.111231. ⟨10.1016/j.celrep.2022.111231⟩
Cell Reports, 2022, 40 (8), pp.111231. ⟨10.1016/j.celrep.2022.111231⟩
International audience; There is a continued unmet need for treatments that can slow Parkinson's disease progression due to the lack of understanding behind the molecular mechanisms underlying neurodegeneration. Since its discovery, ferroptosis has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b27c4e302eadacc48ae4fca29821df5
https://hal.inrae.fr/hal-03813276/file/mahoney-sanchez_2022_vol40_111231_cell_rep.pdf
https://hal.inrae.fr/hal-03813276/file/mahoney-sanchez_2022_vol40_111231_cell_rep.pdf
Autor:
James A. Duce, Bruce X. Wong, Catriona McLean, Blaine R. Roberts, Peter J. Barnard, Adam P Gunn, Christopher Fowler
Publikováno v:
Journal of Neurochemistry. 156:979-987
Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9c9552cf2884f81bea2cfa18b4100
https://doi.org/10.1111/jnc.15114
https://doi.org/10.1111/jnc.15114
Autor:
Scott Ayton, Adam P Gunn, James A. Duce, Ashley I. Bush, Andrew Tsatsanis, David Devos, Bruce X. Wong
Publikováno v:
Molecular Psychiatry. 25:1958-1966
The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis of Alzheimer's disease (AD) because APP mutations that influence this processing either induce familial AD or mitigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e316c74021ae8dae0da83a5d0e614dc
https://doi.org/10.1038/s41380-020-0762-0
https://doi.org/10.1038/s41380-020-0762-0
Autor:
Frank W, Lewis, Kathleen, Bird, Jean-Philippe, Navarro, Rawa, El Fallah, Jeremy, Brandel, Véronique, Hubscher-Bruder, Andrew, Tsatsanis, James A, Duce, David, Tétard, Samuel, Bourne, Mahmoud, Maina, Ilse S, Pienaar
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 51(9)
Iron dysregulation, dopamine depletion, cellular oxidative stress and α-synuclein protein mis-folding are key neuronal pathological features seen in the progression of Parkinson's disease. Iron chelators endowed with one or more therapeutic modes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca24ea8a13b9756a8f9991eeb5ee661a
https://pubmed.ncbi.nlm.nih.gov/35147617
https://pubmed.ncbi.nlm.nih.gov/35147617
Autor:
James A. Duce, Asipu Sivaprasadarao, Ellis Patrick, Andrew N. McCorkindale, Boris Guennewig, Andrew Tsatsanis, Robert W. Evans, Greg T. Sutherland, Bruce X. Wong, Ashley I. Bush, Timothy M. Ryan
Publikováno v:
Molecular Psychiatry
Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extracellular plaques of AD. Additional early cortical changes in AD include neuroinflammation and elevated iron levels. Act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a332cc2f1c5b0b7b84ecee34c03f5d0
Publikováno v:
Frontiers in aging neuroscience. 14
Dementia affects millions of individuals worldwide, yet there are no effective treatments. Alzheimer’s disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to precipitate tau pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ff8112ddb7bb290fa81827247f6fd8
https://pubmed.ncbi.nlm.nih.gov/35557837
https://pubmed.ncbi.nlm.nih.gov/35557837