Zobrazeno 1 - 10
of 266
pro vyhledávání: '"James A Duce"'
Autor:
McGuire, Carl
Publikováno v:
The Journal of Energy and Development, 1976 Oct 01. 2(1), 175-178.
Externí odkaz:
https://www.jstor.org/stable/24806187
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Dementia affects millions of individuals worldwide, yet there are no effective treatments. Alzheimer’s disease, the most common form of dementia, is characterized by amyloid and tau pathology with amyloid accumulation thought to precipitate tau pat
Externí odkaz:
https://doaj.org/article/a6400731b99344c38baaa8195641f12a
Autor:
James A. Duce, Bruce X. Wong, Hannah Durham, Jean-Christophe Devedjian, David P. Smith, David Devos
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-12 (2017)
Abstract Parkinson’s disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neur
Externí odkaz:
https://doaj.org/article/9b2ac27b9d134c9db0856f755df42bc5
Autor:
Teresa R. Taylor-Whiteley, Christine L. Le Maitre, James A. Duce, Caroline F. Dalton, David P. Smith
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 4 (2019)
Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated L
Externí odkaz:
https://doaj.org/article/42b8eb5ea8f5428785fecf6ccddb50fa
Publikováno v:
The Annals of the American Academy of Political and Social Science, 1970 Nov 01. 392, 218-218.
Externí odkaz:
https://www.jstor.org/stable/1039618
Autor:
Hind Bouchaoui, Laura Mahoney-Sanchez, Guillaume Garçon, Olivier Berdeaux, Laurent Y. Alleman, David Devos, James A. Duce, Jean-Christophe Devedjian
Publikováno v:
Free Radical Biology and Medicine
Free Radical Biology and Medicine, 2023, 195, pp.145-157. ⟨10.1016/j.freeradbiomed.2022.12.086⟩
Free Radical Biology and Medicine, 2023, 195, pp.145-157. ⟨10.1016/j.freeradbiomed.2022.12.086⟩
International audience; Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels, has been implicated in several neurodegenerative diseases, including Parkinson's disease (PD). Brain regions such as the striatum are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1f09be69c8027a971a32af0aec4e7f
https://pubmed.ncbi.nlm.nih.gov/36581060
https://pubmed.ncbi.nlm.nih.gov/36581060
Autor:
Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184104 (2017)
Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA) from dietary vitamin B5, but the neuropathological mechanism and reasons for iron accumulation remain unknown. In this
Externí odkaz:
https://doaj.org/article/f5f6c31baff54e20bd2c981bf542ab13
Autor:
Laura Mahoney-Sanchez, Hind Bouchaoui, Ibrahim Boussaad, Aurélie Jonneaux, Kelly Timmerman, Olivier Berdeaux, Scott Ayton, Rejko Krüger, James A. Duce, David Devos, Jean-Christophe Devedjian
Publikováno v:
Cell Reports
Cell Reports, 2022, 40 (8), pp.111231. ⟨10.1016/j.celrep.2022.111231⟩
Cell Reports, 2022, 40 (8), pp.111231. ⟨10.1016/j.celrep.2022.111231⟩
International audience; There is a continued unmet need for treatments that can slow Parkinson's disease progression due to the lack of understanding behind the molecular mechanisms underlying neurodegeneration. Since its discovery, ferroptosis has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b27c4e302eadacc48ae4fca29821df5
https://hal.inrae.fr/hal-03813276/file/mahoney-sanchez_2022_vol40_111231_cell_rep.pdf
https://hal.inrae.fr/hal-03813276/file/mahoney-sanchez_2022_vol40_111231_cell_rep.pdf
Autor:
James A. Duce, Bruce X. Wong, Catriona McLean, Blaine R. Roberts, Peter J. Barnard, Adam P Gunn, Christopher Fowler
Publikováno v:
Journal of Neurochemistry. 156:979-987
Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9c9552cf2884f81bea2cfa18b4100
https://doi.org/10.1111/jnc.15114
https://doi.org/10.1111/jnc.15114
Autor:
Scott Ayton, Adam P Gunn, James A. Duce, Ashley I. Bush, Andrew Tsatsanis, David Devos, Bruce X. Wong
Publikováno v:
Molecular Psychiatry. 25:1958-1966
The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis of Alzheimer's disease (AD) because APP mutations that influence this processing either induce familial AD or mitigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e316c74021ae8dae0da83a5d0e614dc
https://doi.org/10.1038/s41380-020-0762-0
https://doi.org/10.1038/s41380-020-0762-0