Zobrazeno 1 - 10
of 1 122
pro vyhledávání: '"James A Crowe"'
Autor:
Ivan V. Kuzmin, Ruben Soto Acosta, Layne Pruitt, Perry T. Wasdin, Kritika Kedarinath, Keziah R. Hernandez, Kristyn A. Gonzales, Kharighan Hill, Nicole G. Weidner, Chad Mire, Taylor B. Engdahl, Woohyun J. Moon, Vsevolod Popov, James E. Crowe, Ivelin S. Georgiev, Mariano A. Garcia-Blanco, Robert K. Abbott, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice immu
Externí odkaz:
https://doaj.org/article/b9d9f5258a8943afbcc90d9e051b9c63
Autor:
Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Natalia A. Kuzmina, Kritika Kedarinath, Eduardo Jurado-Cobena, Fuchun Zhou, Chandru Subramani, Matthew A. Hyde, Jalene V. Velazquez, Lauren E. Williamson, Pavlo Gilchuk, Robert H. Carnahan, Galit Alter, James E. Crowe, Alexander Bukreyev
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Antibodies to Ebola virus glycoprotein (EBOV GP) represent an important correlate of the vaccine efficiency and infection survival. Both neutralization and some of the Fc-mediated effects are known to contribute the protection conferred by a
Externí odkaz:
https://doaj.org/article/446ca9702148453eb38e081a5253376d
Autor:
Daniel N. Streblow, Alec J. Hirsch, Jeffrey J. Stanton, Anne D. Lewis, Lois Colgin, Ann J. Hessell, Craig N. Kreklywich, Jessica L. Smith, William F. Sutton, David Chauvin, Jennifer Woo, Benjamin N. Bimber, Cierra N. LeBlanc, Sonia N. Acharya, Brian J. O’Roak, Harjinder Sardar, Mohammad M. Sajadi, Zahra R. Tehrani, Mark R. Walter, Luis Martinez-Sobrido, James J. Kobie, Rachel J. Reader, Katherine J. Olstad, Theodore R. Hobbs, Erica Ollmann Saphire, Sharon L. Schendel, Robert H. Carnahan, Jonas Knoch, Luis M. Branco, James E. Crowe, Koen K. A. Van Rompay, Phillip Lovalenti, Vu Truong, Donald N. Forthal, Nancy L. Haigwood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease in rhesus macaques inoculated with
Externí odkaz:
https://doaj.org/article/8766bd1dd34746b3b375ff5406037cd7
Autor:
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV
Externí odkaz:
https://doaj.org/article/b9951ffe5c244d7b912906b85005d70b
Autor:
Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Natalia A. Kuzmina, Kritika Kedarinath, Eduardo Jurado-Cobena, Fuchun Zhou, Chandru Subramani, Matthew A. Hyde, Jalene V. Velazquez, Lauren E. Williamson, Pavlo Gilchuk, Robert H. Carnahan, Galit Alter, James E. Crowe, Alexander Bukreyev
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/363dea2b3f8140e3a227009c6ff258aa
Autor:
Cynthia M. McMillen, Nathaniel S. Chapman, Ryan M. Hoehl, Lauren B. Skvarca, Madeline M. Schwarz, Laura S. Handal, James E. Crowe, Amy L. Hartman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Rift Valley fever virus (RVFV) is an emerging mosquito-transmitted virus that circulates in livestock and humans in Africa and the Middle East. Outbreaks lead to high rates of miscarriages in domesticated livestock. Women are also at risk of
Externí odkaz:
https://doaj.org/article/b005e172a9a3481db7bdb83e145d536f
Autor:
Rodrigo I. Santos, Philipp A. Ilinykh, Colette A. Pietzsch, Adam J. Ronk, Kai Huang, Natalia A. Kuzmina, Fuchun Zhou, James E. Crowe, Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113254- (2023)
Summary: Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV out
Externí odkaz:
https://doaj.org/article/8a1292785f724a3abef3fab20ae45612
Autor:
James Brett Case, Samantha Mackin, John M. Errico, Zhenlu Chong, Emily A. Madden, Bradley Whitener, Barbara Guarino, Michael A. Schmid, Kim Rosenthal, Kuishu Ren, Ha V. Dang, Gyorgy Snell, Ana Jung, Lindsay Droit, Scott A. Handley, Peter J. Halfmann, Yoshihiro Kawaoka, James E. Crowe, Daved H. Fremont, Herbert W. Virgin, Yueh-Ming Loo, Mark T. Esser, Lisa A. Purcell, Davide Corti, Michael S. Diamond
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
SARS-CoV-2 variants of concern are less susceptible to therapeutic neutralizing antibodies, given mutations in the surface glycoprotein S. Here, Case et al. show that therapeutic antibodies S309 and AZD7442 reduce lung infection with SARSCoV-2 Omicro
Externí odkaz:
https://doaj.org/article/8a854a9e359e4ddf9ea916e8a8feb054
Autor:
Kevin J. Kramer, Erin M. Wilfong, Kelsey Voss, Sierra M. Barone, Andrea R. Shiakolas, Nagarajan Raju, Caroline E. Roe, Naveenchandra Suryadevara, Lauren M. Walker, Steven C. Wall, Ariana Paulo, Samuel Schaefer, Debolanle Dahunsi, Camille S. Westlake, James E. Crowe, Robert H. Carnahan, Jeffrey C. Rathmell, Rachel H. Bonami, Ivelin S. Georgiev, Jonathan M. Irish
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Vaccination against COVID-19 has shown activation of different immune cell types. Here the authors characterise the immune response to the SARS-CoV-2 mRNA vaccine using longitudinal CyTOF single cell approaches to characterise antigen specific B and
Externí odkaz:
https://doaj.org/article/54f0d07dda6a4419baae2ec37e6174d0
Autor:
Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe, Pamela J. Bjorkman, Jens Meiler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequ
Externí odkaz:
https://doaj.org/article/f9573f4cd2774fcb9a4cbb1c42411547